Search results for "raga"
showing 10 items of 1852 documents
Long-term monitoring of mrk 501 for its very high energy γ emission and a flare in 2011 october
2012
"As one of the brightest active blazars in both X-ray and very high energy γ -ray bands, Mrk 501, is very useful for" "physics associated with jets from active galactic nuclei. The ARGO-YBJ experiment has monitored Mrk 501 for γ - rays above 0.3 TeV since 2007 November. The largest flare since 2005 was observed from 2011 October and lasted until about 2012 April. In this paper, a detailed analysis of this event is reported. During the brightest γ -ray flaring episodes from 2011 October 17 to November 22, an excess of the event rate over 6σ is detected by ARGO-YBJ in the direction of Mrk 501, corresponding to an increase of the γ -ray flux above 1 TeV by a factor of 6.6 ± 2.2 from its steady…
Non-pheochromocytoma (PCC)/paraganglioma (PGL) tumors in patients with succinate dehydrogenase-related PCC-PGL syndromes: a clinicopathological and m…
2014
ObjectiveAlthough the succinate dehydrogenase (SDH)-related tumor spectrum has been recently expanded, there are only rare reports of non-pheochromocytoma/paraganglioma tumors in SDHx-mutated patients. Therefore, questions still remain unresolved concerning the aforementioned tumors with regard to their pathogenesis, clinicopathological phenotype, and even causal relatedness to SDHx mutations. Absence of SDHB expression in tumors derived from tissues susceptible to SDH deficiency is not fully elucidated.Design and methodsThree unrelated SDHD patients, two with pituitary adenoma (PA) and one with papillary thyroid carcinoma (PTC), and three SDHB patients affected by renal cell carcinomas (RC…
Hypoxia-Inducible Factor 2α Mutation-Related Paragangliomas Classify as Discrete Pseudohypoxic Subcluster
2016
Contains fulltext : 172720.pdf (Publisher’s version ) (Open Access) Recently, activating mutations of the hypoxia-inducible factor 2alpha gene (HIF2A/EPAS1) have been recognized to predispose to multiple paragangliomas (PGLs) and duodenal somatostatinomas associated with polycythemia, and ocular abnormalities. Previously, mutations in the SDHA/B/C/D, SDHAF2, VHL, FH, PHD1, and PHD2 genes have been associated with HIF activation and the development of pseudohypoxic (cluster-1) PGLs. These tumors overlap in terms of tumor location, syndromic presentation, and noradrenergic phenotype to a certain extent. However, they also differ especially by clinical outcome and by presence of other tumors o…
Somatostatin-producing neuroendocrine tumors of the duodenum and pancreas: incidence, types, biological behavior, association with inherited syndrome…
2008
Somatostatin-producing neuroendocrine tumors (SOM-NETs) of the duodenum and pancreas appear to be heterogeneous. To determine their clinicopathological profiles, respective data were analyzed on a series of 82 duodenal and 541 pancreatic NETs. In addition, the clinical records of 821 patients with duodenal or pancreatic NETs were reviewed for evidence of a somatostatinoma syndrome. Predominant or exclusive expression of somatostatin was found in 21 (26%) duodenal and 21 (4%) pancreatic NETs. They were classified as sporadic (n=31) or neurofibromatosis type 1 (NF1)-associated duodenal NETs (n=3), gangliocytic paragangliomas (GCPGs; n=6), or poorly differentiated neuroendocrine carcinomas (pd…
Management of head and neck paragangliomas: review of 120 patients.
2008
Head and neck paragangliomas (PGL) are rare, mostly benign tumors. About 10% to 15% of PGL are caused by mutations in the succinate dehydrogenase genes B, C, or D and may appear multifocally.A retrospective review of 120 patients with 146 head and neck PGL, including 46 carotid body tumors (CBT), 13 vagal tumors, 55 jugulotympanic tumors (JTT), 25 tympanic tumors (TT) and 7 tumors in other locations are included. The internal carotid artery was preserved in 97.5% of CBT resections. Preservation of hearing was achieved in 92% of JTT and 88% of TT resections.According to our experience, the treatment of PGL must be individualized, taking into account the patient's age, medical condition, tumo…
Malignant paraganglioma caused by a novel germline mutation of the succinate dehydrogenase D-gene--a case report.
2008
Background Paragangliomas of the head and neck are rare, mostly benign tumors. Approximately 10% to 15% of paragangliomas are caused by mutations in the succinate dehydrogenase (SDH) genes B, C, or D. These are often multifocal as part of paraganglioma syndromes and hormone secreting, and malignant particularly associated with mutations in SDHB. Methods and Results A 29-year-old man was seen with recurrent paraganglioma. The patient's father reportedly suffered from bilateral carotid body tumors. Imaging studies showed metastases in both lungs and the liver. There was no increased hormone production by the tumor. Sequence analysis of the SDH genes revealed a novel C to T nonsense mutation i…
Data from: Effects of undergrowth removal and edge proximity on ground beetles and vascular plants in urban boreal forests
2019
Urban forests are regularly managed for human safety and aesthetic reasons, but they are crucial habitat for many species. Removals of undergrowth occur commonly in these forests, yet the ecological consequences of these operations are poorly understood. We sampled ground beetles (Coleoptera, Carabidae) and vascular plants along 20-m edge gradients in Finnish urban forests, in five stands treated 0.5−2.5 years earlier with undergrowth removal and in five untreated stands. We hypothesized that undergrowth removal and edge proximity would benefit opportunistic and open-habitat species, whereas shady-habitat species would be affected negatively. (1) Regarding carabids, diversity and evenness i…
La grande Akragas. Dalla valle dei templi alla città dei templi fra piani, progetti e tabula rasa
2018
La riflessione scaturita da un laboratorio di laurea intitolato: La grande Akragas ha offerto l’occasione per ragionare sul concetto di resilienza urbana alla luce delle potenzialità del progetto di architettura. La denominazione dell’attività didattica palesa il luogo del ragionamento, Agrigento per l’appunto, città siciliana posta a pochi chilometri dalla costa sud occidentale dell’Isola, famosa per il parco archeologico della Valle dei Templi. In età contemporanea la notorietà di Girgenti giunge al suo acme nell’Ottocento, quando diventa una delle tappe obbligatorie del Grand Tour e i templi sono rilevati e studiati dai più importanti architetti d’Europa. Questo ricchissimo patrimonio ha…
Sacelli "dimenticati" nell’area urbana di Akragas
2016
International audience; Between 1927 and 1930, Pirro Marconi investigated a small rectangular structure near house Filippazzo, in the central urban area of Akragas. The presence of a bothros and fragments of female figures with stephane suggested the presence of a small sanctuary or themenos for chthonic deities. The little news published by Marconi and the vague indication of location made us forget the existence of this sanctuary for many years. However, a survey carried out in 2016 allowed to identify the remains of Marconi’s structure, partly covered by ground. At the same time, other little-known structures have been identified. In some cases, their function is still unknown.
Le fortificazioni di Akragas: il settore presso la cosiddetta Porta Aurea
2020
L’identificazione della porta ad mare ferens, ricordata da Livio per le vicende della conquista romana di Agrigento nel 211/0 a.C., ha costituito uno degli argomenti di maggior interesse per gli studiosi della topografia della città, in connessione con la localizzazione dell’agorà-foro e del non lontano tempio di Eracle/Ercole. Nel quindicennio scorso ha prevalso l’ipotesi, avanzata da G. Tripodi nel 2003, che la porta principale di collegamento con la costa sia da ubicare a Est (attuale giardino di Villa Aurea) e non già ad Ovest (sito della cosiddetta Porta Aurea) del Tempio A/ cosiddetto Tempio di Eracle; da ultimo, V. Caminneci e G. Cucchiara hanno invece rivalutato l’importanza anche d…