Search results for "randomized"

showing 10 items of 2323 documents

Widening use of dexamethasone implant for the treatment of macular edema

2017

Vincenza Bonfiglio, Michele Reibaldi, Matteo Fallico, Andrea Russo, Alessandra Pizzo, Stefano Fichera, Carlo Rapisarda, Iacopo Macchi, Teresio Avitabile, Antonio Longo Department of Ophthalmology, University of Catania, Catania, Italy Abstract: Sustained-release intravitreal 0.7 mg dexamethasone (DEX) implant is approved in Europe for the treatment of macular edema related to diabetic retinopathy, branch retinal vein occlusion, central retinal vein occlusion, and non-infectious uveitis. The implant is formulated in a biodegradable copolymer to release the active ingredient within the vitreous chamber for up to 6 months after an intravitreal injection, allowing a prolonged interval of effica…

3003intravitrealgenetic structuresimplantmedicine.medical_treatmentPharmaceutical ScienceVitrectomyReviewDrug Implantcorticosteroids0302 clinical medicineGlucocorticoidCentral retinal vein occlusionDrug DiscoveryDelayed-Action PreparationCorticosteroidRandomized Controlled Trials as TopicDrug ImplantsCorticosteroids; Dexamethasone; Implant; Intravitreal; Macular edema; Pharmacology; 3003; Drug Discovery3003 Pharmaceutical ScienceDiabetic retinopathyIntravitreal InjectionsUveitismedicine.drugHumanmedicine.medical_specialtydexamethasone03 medical and health sciencesOphthalmologymedicineHumansMacular edemaGlucocorticoidsDexamethasonePharmacologyMacular edemaDiabetic Retinopathybusiness.industryIntravitreal InjectionDrug Discovery3003 Pharmaceutical Sciencelcsh:RM1-950Macular degenerationmedicine.diseaseeye diseasesSurgerylcsh:Therapeutics. PharmacologyDelayed-Action Preparations030221 ophthalmology & optometryBranch retinal vein occlusionsense organsbusiness030217 neurology & neurosurgeryDrug Design, Development and Therapy
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Transformational leadership development to reduce employee sickness absence: A randomized controlled trial

2022

Objetivo - Dado que muchas organizaciones se enfrentan a un aumento de las bajas por enfermedad entre sus empleados, se ha destacado en la literatura el potencial del liderazgo transformacional para mejorar la salud de los empleados y gestionar más eficazmente las bajas por enfermedad. Sin embargo, las pruebas empíricas existentes sobre esa asociación no son concluyentes y son ambiguas, ya que se basan en métodos de investigación no experimentales y en medidas de resultado subjetivas. Además, sigue sin estar claro si un líder transformacional puede realmente mejorar la salud de los empleados o más bien aumentar la motivación para asistir al trabajo. Además, hay un conocimiento limitado de l…

:CIENCIAS ECONÓMICAS::Organización y dirección de empresas ::Organización de recursos humanos [UNESCO]UNESCO::CIENCIAS ECONÓMICAS::Organización y dirección de empresas ::Organización de recursos humanosTransformational leadershipRandomized controlled trialUNESCO::CIENCIAS MÉDICAS ::Medicina del trabajo::Salud profesional:PSICOLOGÍA::Psicología social ::Liderazgo [UNESCO]:CIENCIAS MÉDICAS ::Medicina del trabajo::Salud profesional [UNESCO]UNESCO::PSICOLOGÍA::Psicología social ::LiderazgoSickness absence
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Safety Evaluation of α-Lipoic Acid Supplementation: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Studies

2020

Alpha-lipoic acid (ALA) is a natural short-chain fatty acid that has attracted great attention in recent years as an antioxidant molecule. However, some concerns have been recently raised regarding its safety profile. To address the issue, we aimed to assess ALA safety profile through a systematic review of the literature and a meta-analysis of the available randomized placebo-controlled clinical studies. The literature search included EMBASE, PubMed Medline, SCOPUS, Google Scholar, and ISI Web of Science by Clarivate databases up to 15th August 2020. Data were pooled from 71 clinical studies, comprising 155 treatment arms, which included 4749 subjects with 2558 subjects treated with ALA an…

:Chemicals and Drugs::Pharmaceutical Preparations::Placebos [Medical Subject Headings]Physiologyα -lipoic acid ; thioctic acid ; dietary supplement ; safety ; meta-analysisClinical BiochemistryDisease030204 cardiovascular system & hematologyBiochemistrymeta-analysi:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidants [Medical Subject Headings]Dietary supplementchemistry.chemical_compound0302 clinical medicinethioctic aciddietary supplement meta-analysis safety thioctic acid α-lipoic acid:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Clinical Trials as Topic::Controlled Clinical Trials as Topic::Randomized Controlled Trials as Topic [Medical Subject Headings]α-lipoic acidLipoic acidSafety profile:Publication Type::Study Characteristics::Meta-Analysis [Medical Subject Headings]Suplementos dietéticosMeta-analysis:Technology and Food and Beverages::Food and Beverages::Food::Dietary Supplements [Medical Subject Headings]SafetysafetyAlpha-lipoic acidmedicine.medical_specialtyMEDLINEÁcido tióctico030209 endocrinology & metabolismPlacebo:Chemicals and Drugs::Organic Chemicals::Sulfur Compounds::Thiophenes::Thioctic Acid [Medical Subject Headings]Article:Health Care::Environment and Public Health::Public Health::Accidents::Accident Prevention::Safety [Medical Subject Headings]03 medical and health sciencesα‐lipoic acidThioctic acidInternal medicineDiabetes mellitusmedicineMetaanálisisAdverse effectSeguridad:Diseases::Cardiovascular Diseases [Medical Subject Headings]Molecular Biology:Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids Volatile [Medical Subject Headings]business.industryRevisión sistemáticalcsh:RM1-950Cell Biologymedicine.disease:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Habits::Food Habits::Smoking [Medical Subject Headings]meta-analysisMeta-analysislcsh:Therapeutics. Pharmacologychemistry:Diseases::Nervous System Diseases [Medical Subject Headings]dietary supplementMeta‐analysisbusinessAntioxidants
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Pain Neuroscience Education and Physical Therapeutic Exercise for Patients with Chronic Spinal Pain in Spanish Physiotherapy Primary Care: A Pragmati…

2020

Producción Científica

:Health Care::Health Services Administration::Patient Care Management::Delivery of Health Care [Medical Subject Headings]lcsh:MedicineChronic painEnsayo clínico controlado aleatoriolaw.invention:Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Nervous System Physiological Phenomena::Central Nervous System Sensitization [Medical Subject Headings]0302 clinical medicineRandomized controlled triallawphysical exerciseNeuroscience educationHealth care:Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Movement::Motor Activity [Medical Subject Headings]030212 general & internal medicine:Health Care::Population Characteristics::Health::Mental Health [Medical Subject Headings]education.field_of_study:Diseases::Pathological Conditions Signs and Symptoms::Signs and Symptoms::Neurologic Manifestations::Pain::Chronic Pain [Medical Subject Headings]Chronic pain:Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Nervous System Physiological Phenomena::Nervous System Physiological Processes::Sensation::Pain::Pain Threshold [Medical Subject Headings]General MedicinePrimary care:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Personal Satisfaction [Medical Subject Headings]Ejercicio físico:Health Care::Health Services Administration::Patient Care Management::Comprehensive Health Care::Primary Health Care [Medical Subject Headings]Randomized controlled trialchronic painchronic spinal painmedicine.medical_specialty:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Methods::Research Design::Control Groups [Medical Subject Headings]PopulationChronic spinal painPhysical exerciseArticleEducación neurocientífica03 medical and health sciencesprimary careQuality of life (healthcare)medicine:Humanities::Humanities::Philosophy::Life::Quality of Life [Medical Subject Headings]educationpain neuroscience educationPain neuroscience educationbusiness.industry:Diseases::Musculoskeletal Diseases::Muscular Diseases::Musculoskeletal Pain [Medical Subject Headings]Public healthlcsh:RPhysical exerciseDolor crónicoAtención primariamedicine.diseaseClinical trialrandomized controlled trialPhysical therapy:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Neurologic Examination::Pain Measurement [Medical Subject Headings]businessNeuroscience030217 neurology & neurosurgeryJournal of Clinical Medicine
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Efficacy of an internet-based psychological intervention for problem gambling and gambling disorder: study protocol for a randomized controlled trial

2021

Gambling Disorder is a prevalent non-substance use disorder, which contrasts with the low number of people requesting treatment. Information and Communication Technologies (ICT) could help to enhance the dissemination of evidence-based treatments and considerably reduce the costs. The current study seeks to assess the efficacy of an online psychological intervention for people suffering from gambling problems in Spain. The proposed study will be a two-arm, parallel-group, randomized controlled trial. A total of 134 participants (problem and pathological gamblers) will be randomly allocated to a waiting list control group (N = 67) or an intervention group (N = 67). The intervention program i…

A ActionDGOJ Directorate General for the Regulation of GamblingCIDI Composite International Diagnostic InterviewPA Positive AffectSPIRIT Standard Protocol Items Recommendations for Interventional TrialsefficacyPsychological interventionMotivational interviewingGE Gambling ExpectanciesDSM-IV Diagnostic and Statistical Manual of Mental Disorders Fourth EditionOASIS The Overall Anxiety Severity and Impairment Scalelaw.inventionDERS Difficulties in Emotion Regulation ScaleRandomized controlled triallawPANAS The Positive and Negative Affect SchedulePsychologyRCT Randomized Controlled TrialUPPS-P The Short UPPS-P Impulsivity ScaleICD-10 International Statistical Classification of Diseases and Related Health Problems 10th RevisionCognitionT58.5-58.64GRCS-S Gambling-Related Cognitions ScalePC Predictive ControlBF1-990EDBs Emotion Driven BehavioursC ContemplationGSEQ Gambling Self-Efficacy QuestionnaireDSM-5 Diagnostic and Statistical Manual of Mental Disorders Fifth EditionAnxietyAddicció a Internetmedicine.symptomMI Motivational InterviewingPsychologyJocs per ordinadorM Maintenancemedicine.medical_specialtyemotion regulationG-SAS The Gambling Symptom Assessment ScaleEMA Ecological Momentary AssessmentODSIS The Overall Depression Severity and Impairment ScaleEfficacyWL Waiting ListIC Illusion of ControlIB Interpretative BiasMFS Monitoring Feedback and SupportCBTHealth InformaticsInformation technologyCBT Cognitive Behavioral TherapyImpulsivityCONSORT-EHEALTH Consolidated Standards of Reporting Trials of Electronic and Mobile Health Applications and Online TelehealthISG Perceived Inability to Stop GamblingQuality of life (healthcare)URICA The University of Rhode Island Change Assessment ScaleIntervention (counseling)medicineGD Gambling DisorderSCID-P The Structured Clinical InterviewPsychiatryQLI Quality Life IndexInternetEmotion regulationFull length ArticleSUS System Usability ScalegamblingEMI Ecological Momentary InterventionMINI Mini International Neuropsychiatric InterviewGI Gambling history interview and current gambling situation and related variables assessmentNA Negative AffectGamblingNODS NORC DSM-IV Screen for Gambling ProblemsPFIs Personal Feedback InterventionsDSM-III-R Diagnostic and Statistical Manual of Mental Disorders 3rd Edition RevisedHADS Hospital Anxiety Depression ScaleinternetP Precontemplation
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Importance of proper conduct of clinical trials

2021

AFRICAclinical trialsModels StatisticalActuarial sciencebusiness.industryMEDICINEinferential statisticsEvidence-based medicinerandomised controlled trialsBayesian statisticsBayesian statisticBayesian statisticsClinical trialAnesthesiology and Pain MedicineResearch DesignData Interpretation StatisticalCausal inferenceStatistical inferenceHumansMedicinecausal inferencebusinessevidence-based medicineRandomized Controlled Trials as Topic
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Do ventilatory parameters influence outcome in patients with severe acute respiratory infection? Secondary analysis of an international, multicentre1…

2021

Purpose: To investigate the possible association between ventilatory settings on the first day of invasive mechanical ventilation (IMV) and mortality in patients admitted to the intensive care unit (ICU) with severe acute respiratory infection (SARI). Materials and methods: In this pre-planned sub-study of a prospective, multicentre observational study, 441 patients with SARI who received controlled IMV during the ICU stay were included in the analysis. Results: ICU and hospital mortality rates were 23.1 and 28.1%, respectively. In multivariable analysis, tidal volume and respiratory rate on the first day of IMV were not associated with an increased risk of death; however, higher driving pr…

ARDSSoins intensifs réanimationmedicine.medical_treatmentAirway pressuresPEEP positive end-expiratory pressureCritical Care and Intensive Care Medicinelaw.inventionHypoxemiaCohort StudiesPositive-Pressure RespirationMechanical ventilationSARI severe acute respiratory infectionlawHospital MortalityProspective StudiesIQR interquartile rangesProspective cohort studyRCT randomized controlled trialTidal volumeSOFA Sequential Organ Failure AssessmentSAPS Simplified Acute Physiology ScoreIntensive care unitVCV volume-controlled ventilationHIV human immunodeficiency virusIntensive Care UnitsIC GLOSSARI Intensive Care Global Study on Severe Acute Respiratory Infectionmedicine.symptomCohort studyLOS length of staymedicine.medical_specialtyVt tidal volumeCOPD Chronic obstructive pulmonary diseaseNYHA New York Heart Association.PCV pressure-controlled ventilationArticleInternal medicineICU Intensive Care UnitSIMV Synchronized intermittent mandatory ventilationmedicineTidal VolumeHumansDP driving pressurePEEPARDS acute respiratory distress syndromeMechanical ventilationbusiness.industryOdds ratioPneumoniaPlateau pressuremedicine.diseaseRespiration ArtificialVILI ventilator induced lung injuryCI confidence intervalOR odds ratioIMV invasive mechanical ventilationCPAP continuous positive airway pressureARDSbusinessSD standard deviationECMO extracorporeal membrane oxygenationPBW predicted body weightPplat plateau pressure
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Automatic Segmentation of HEp-2 Cells Based on Active Contours Model

2018

In the past years, a great deal of effort was put into research regarding Indirect Immunofluorescence techniques with the aim of development of CAD systems. In this work a method for segmenting HEp-2 cells in IIF images is presented. Such task is one of the most challenging of automated IIF analysis, because the segmentation algorithm has to cope with a large heterogeneity of shapes and textures. In order to address this problem, numerous techniques and their combinations were evaluated, in a process aimed at maximizing the figure of merit. The proposed method, for a greater definition of cellular contours, uses the active contours in the last phase of the process. The initial conditions, c…

Active contour modelComputer sciencebusiness.industryHEp-2 cellComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISIONProcess (computing)Pattern recognitionEllipseDice indexSettore FIS/07 - Fisica Applicata(Beni Culturali Ambientali Biol.e Medicin)Hough transformlaw.inventionRandomized Hough transformHough transformlawPosition (vector)Convergence (routing)SegmentationArtificial intelligencebusinessActive contours modelCells segmentationIIF imagesProceedings of the 2018 3rd International Conference on Biomedical Imaging, Signal Processing
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A new approach to ticagrelor-based de-escalation of antiplatelet therapy after acute coronary syndrome. A rationale for a randomized, double-blind, p…

2021

The risk of ischemic events gradually decreases after acute coronary syndrome (ACS), reaching a stable level after 1 month, while the risk of bleeding remains steady during the whole period of dual antiplatelet treatment (DAPT). Several de-escalation strategies of antiplatelet treatment aiming to enhance safety of DAPT without depriving it of its efficacy have been evaluated so far. We hypothesized that reduction of the ticagrelor maintenance dose 1 month after ACS and its continuation until 12 months after ACS may improve adherence to antiplatelet treatment due to better tolerability compared with the standard dose of ticagrelor. Moreover, improved safety of treatment and preserved anti-is…

Acute coronary syndromemedicine.medical_specialtyELECTRA-SIRIO 2TicagrelorClinical CardiologyPlaceboantiplatelet therapylaw.inventionacute coronary syndrometicagrelorClinical studyPercutaneous Coronary InterventionRandomized controlled triallawInternal medicinemedicineHumansAcute Coronary SyndromeAspirinbusiness.industryMaintenance doseGeneral Medicinemedicine.diseasede-escalationTolerabilityELECTRA-SIRIO 2 ; acute coronary syndrome ; antiplatelet therapy ; de-escalation ; ticagrelorCardiologyCardiology and Cardiovascular MedicinebusinessTicagrelorDe-escalationPlatelet Aggregation Inhibitorsmedicine.drug
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High definition colonoscopy combined with i-Scan is superior in the detection of colorectal neoplasias compared with standard video colonoscopy: a pr…

2010

Introduction Colonoscopy is the accepted gold standard for the detection of colorectal cancer. The aim of the current study was to prospectively compare high definition plus (HD+) colonoscopy with I-Scan functionality (electronic staining) vs. standard video colonoscopy. The primary endpoint was the detection of patients having colon cancer or at least one adenoma. Methods A total of 220 patients due to undergo screening colonoscopy, postpolypectomy surveillance or with a positive occult blood test were randomized in a 1 : 1 ratio to undergo HD+ colonoscopy in conjunction with I-Scan surface enhancement (90i series, Pentax, Tokyo, Japan) or standard video colonoscopy (EC-3870FZK, Pentax). D…

AdenomaMalemedicine.medical_specialtyAdenomaColorectal cancerColonoscopyColonic PolypsGastroenterologylaw.inventionRandomized controlled triallawInternal medicineClinical endpointmedicineHumansProspective StudiesProspective cohort studyEarly Detection of CancerAgedmedicine.diagnostic_testbusiness.industryGastroenterologyGold standard (test)ColonoscopyMiddle Agedmedicine.diseaseImage EnhancementEndoscopyFemaleRadiologybusinessColorectal NeoplasmsEndoscopy
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