Search results for "ratifica"

Impact of the EndoPredict-clin score on risk stratification in ER-positive, HER2-negative breast cancer after considering clinical guidelines.

2012

542 Background: Many ER-positive, HER2-negative breast cancer patients are treated by adjuvant chemotherapy according to current clinical guidelines. We retrospectively assessed whether the combined gene expression/ clinicopathological EndoPredict-clin (EPclin) score improved the accuracy of risk classification in addition to considering clinical guidelines. Methods: Three clinical breast cancer guidelines (National Comprehensive Cancer Center Network (NCCN), German S3 and St. Gallen 2011), and the EPclin score - assessed by quantitative RT-PCR in formalin-fixed paraffin-embedded tissue - were used to assign risk groups in 1,702 ER-positive, HER2-negative breast cancer patients from two ra…

The role of sentinel node tumor burden in modeling the prognosis of melanoma patients with positive sentinel node biopsy: an Italian melanoma intergr…

2022

Abstract Background: The management of melanoma patients with metastatic sentinel nodes (SN) is evolving based on the results of trials questioning the impact of completion lymph node dissection (CLND) and demonstrating the efficacy of new adjuvant treatments. In this landscape, new prognostic tools for fine risk stratification are eagerly sought to optimize the therapeutic path of these patients. Methods: A retrospective cohort of 2,086 patients treated with CLND after a positive SN biopsy in thirteen Italian Melanoma Centers was reviewed. Overall survival (OS) was the outcome of interest; included independent variables were the following: age, gender, primary melanoma site, Breslow thickn…

Prognostic Stratification For Curatively Resected NSCLC Patients By Apoptosis Panel

2010

Thromboprophylaxis after renal transplantation and patient risk stratification: The case of mTOR inhibitors.

2020

The usage of social media among young adults living in Nairobi, Kenya : only entertainment or contributions to societal change?

2015

Social media usage has been found to have increased all over the world, also in the so-called developing countries. Although the percentages are still rather low, it can be argued that the use of social media is becoming increasingly important also in African countries. Kenya has been found to be one of the leading countries regarding social media usage in East Africa. Although research on social media has been conducted, for instance, on the use of social media in protest movements and in the areas of users’ motivation, less emphasis has been placed on their developmental aspects. Thus, to gain a deeper understanding of the usage of social media in the so-called developing countries, this …

Are Polygenic Risk Scores for Major Mental Disorders Associated with General or Specific Psychosis Symptom dimensions?

2019

Background Psychotic symptoms can be conceptualised as dimensions of psychopathology cutting across diagnostic boundaries. Thus, they might be considered enhanced quantitative phenotypes to relate to genetic variants as summarised by Polygenic Risk Scores (PRSs) for Major Mental Disorders (MMDs), including Schizophrenia (SZ), Bipolar Disorder (BP), and Major Depressive Disorder (MDD). The objectives of this study were to: 1) identify the dimensional structure of symptoms at First Episode Psychosis (FEP), testing whether a bi-factor model statistically fits the conceptualization of psychosis as a single common construct (general psychosis factor) while also recognising multidimensionality (p…

Anomalies from nonfree action of the gauge group

1990

Abstract The question whether new anomalies appear, connected with the finite dimensional part of the gauge group isomorphic to the structure group of the theory, is investigated in a systematical way. The stability groups from the stratification of the gauge group on the space of connections lead to anomalies. The detection of these anomalies within the equivariant approach pursued here is extremely simple. For a large class of theories it is shown that no new anomalies appear.

Linear and non-linear stability of a thermally stratified magnetically driven rotating flow in a cylinder

2010

The stability of a thermally stratified liquid metal flow is considered numerically. The flow is driven by the rotating magnetic field in a cylinder heated from above and cooled from below. The stable thermal stratification turns out to destabilise the flow. This is explained by the fact that a stable stratification suppresses the secondary meridional flow, thus indirectly enhancing the primary rotation. The instability in the form of Taylor-Görtler rolls is consequently promoted. It is known from earlier studies that these rolls can be only excited by finite disturbances in the isothermal flow. A sufficiently strong thermal stratification transforms this non-linear bypass instability into …

The Impact of Population Ageing and Social Stratification: The Case of Latvia

2019

Population ageing and social stratification is widely assumed to have detrimental effects on the economy yet there is little empirical evidence about the magnitude of its effects. The aim of this article is to investigate the relationships between population ageing and social stratification and the state of economy of a small and post-transition economy. We are looking for these relationships and their strength of influence; at what time after shocking these variables reach their original levels. We apply standard Granger (non-) causality tests, VAR (Vector Auto-Regressive), IRF (Impulse Response Function) and the prediction error variance analysis by using quarterly data from 2000 to 2018.…

Pay Now, Consume Later: The Power of Delayed Gratification

2021

This chapter analyzes the birth and development of modern tourism. The bubble model, an economic instrument that originated in Fordism, provides the direction to this analysis. Mass-scale production generated much frustration and discontent in society. Economists who historically suggested consumption as a great malady for the economy emphasize consumers’ self-control as the only way to reach a zero-poverty society. Tourism not only revitalized the social frustration of capitalism but also allowed rapid globalization of the world. For this project to be successful, all-paid packages and tours were widely offered to travelers. Prepaid tours or all-inclusive tours emerged as an excellent reas…