Search results for "ratifica"
showing 10 items of 258 documents
Dinámicas de legitimación de la desregulación laboral en España
2021
En esta tesis problematizamos la desregulación de las relaciones laborales desde el punto de vista de los automatismos y de las predisposiciones ejercidas por los actores del mercado laboral, entre los que incluimos tanto a los agentes reguladores como a los/as trabajadores/as. Es decir, desde el sentido práctico que la acción de la desregulación adquiere en un contexto de expansión de la hegemonía neoliberal, en el que subyacen los mecanismos de dominación que se imponen al quedar ocultos bajo un lenguaje organizador de lo flexible, por el que los/as trabajadores/as, acaban por pensarse a sí mismos/as como trabajadores/as desregulados/as. Se utilizan dos enfoques teóricos complementarios y…
High-sensitivity troponin I for risk stratification in normotensive pulmonary embolism
2020
While numerous studies have confirmed the prognostic role of high-sensitivity troponin T (hsTnT) in pulmonary embolism (PE), high-sensitivity troponin I (hsTnI) is inappropriately studied. This study aimed to investigate the prognostic relevance of hsTnI in normotensive PE, establish the optimal cut-off value for risk stratification and to compare the prognostic performances of hsTnI and hsTnT. Based on data from 459 consecutive PE patients enrolled in a single-centre registry, receiver operating characteristic analysis was used to identify an optimal hsTnI cut-off value for prediction of in-hospital adverse outcomes (PE-related death, cardiopulmonary resuscitation or vasopressor treatment)…
Prognostic impact of copeptin in pulmonary embolism: a multicentre validation study.
2018
To externally validate the prognostic impact of copeptin, either alone or integrated in risk stratification models, in pulmonary embolism (PE), we performed a post hoc analysis of 843 normotensive PE patients prospectively included in three European cohorts.Within the first 30 days, 21 patients (2.5%, 95% CI 1.5–3.8) had an adverse outcome and 12 (1.4%, 95% CI 0.7–2.5) died due to PE. Patients with copeptin ≥24 pmol·L−1 had a 6.3-fold increased risk for an adverse outcome (95% CI 2.6–15.5, p<0.001) and a 7.6-fold increased risk for PE-related death (95% CI 2.3–25.6, p=0.001). Risk classification according to the 2014 European Society of Cardiology (ESC) guideline algorithm identified 248…
Prognostic Value of Troponins in Patients With or Without Coronary Heart Disease: Is it Dependent on Structure and Biology?
2020
Convincing evidence has emerged that cardiac troponins (cTns) T and I are the biochemical gold standard for diagnosing cardiac injury, and may also be used as efficient screening and risk stratification tools, especially when measured with the new high-sensitivity (hs-) immunoassays. In this narrative review, we aim to explore and critically discuss the results of recent epidemiological studies that have attempted to characterise the prognostic value of cTns in patients with or without cardiovascular disease, and then interpret this information according to cTn biology. Overall, all recent studies agree that higher blood levels of cTns reflect the larger risk of cardiovascular events and/or…
Patterns of oncogene co-expression at single cell resolution in cancer influence survival
2020
AbstractBackgroundCancers often overexpress multiple clinically relevant oncogenes. However, it is not known if multiple oncogenes within a cancer combine uniquely in specific cellular sub-populations to influence clinical outcome. We studied this phenomenon using the prognostically relevant oncogenes MYC, BCL2 and BCL6 in Diffuse Large B-Cell Lymphoma (DLBCL).MethodsQuantitative multispectral imaging simultaneously measured oncogene co-expression at single-cell resolution in reactive lymphoid tissue (n=12) and four independent cohorts (n=409) of DLBCL. Mathematically derived co-expression phenotypes were evaluated in DLBCLs with immunohistochemistry (n=316) and eight DLBCL cohorts with gen…
From limit to centrality. Regeneration of the Genoa's port area through architectural and urban design
2012
This survey’s core is the case study of the regeneration of the port area and of the urban waterfront of the city of Genoa, as an emblematic example where the architectural and urban design plays an important role, oriented to the transformation of the port area and to the modification of the relationship that exists between the harbour and the city. In particular this will deepen the possibility, to reverse the condition of limit that characterizes the port area into a new centrality, through the design, passing by intermediate steps that redefine the modalities of access and of connection between city and port, breaking the condition of isolation that ports usually present. As a matter of…
The financial autonomy of the municipalities and the Valencian Parliament
2009
In the first half of the fourteenth century and on countless occasions, the Crown granted the leaders of the City of Valencia authorization to collect indirect taxes as a means of collecting the subsidies allocated to its military needs. The ratification of fiscal autonomy can be related to the Crown's interest in gaining control of municipal resources as a way of demanding donations in order to accomplish its policies. The main reason for the royal privilege to raise taxes in favour of the cities was the extensive expenses caused by the conquest of Corsica and Sardinia during the reign of James II. The Kingdom and the city of Valencia came to the aid of the monarch because they were intere…
Restauri a Palermo. Architettura e città come stratificazione
2012
Nel volume sono delineate le principali questioni relative al restauro architettonico, dal punto di vista teorico-culturale e apllicativo, a Palermo, dal dopoguerra ad oggi. Il centro storico viene analizzato nella sua realtà complessa, caratterizzata dalla stratificazione determinata da secoli di storia e di culture diverse, il cui mantenimento diventa esigenza insopprimibile perchè Palermo possa salvaguardare la sua identità.
The Revision Procedures of the Treaty
2011
A review of the diverse reforms of constituent Treaties of the European Communities shows that the revision procedures have not occupied an outstanding place in the design of the constitutional structure of the European Union (EU). That is especially true if we consider two terms in connection: revision (of the Treaties) and ratification (by the States Parties).
Controversial issues in soft tissue solitary fibrous tumors: A pathological and molecular review
2019
The clinical evolution of solitary fibrous tumor (SFT) remains unclear. Although various clinical, morphological and molecular criteria may indicate increased risk of malignancy, some SFT can still progress despite having a clearly benign appearance. Various risk stratification systems have been proposed, but unfortunately they are not sufficient to precisely determine the malignant potential. In this review, we discuss current knowledge on SFT, focusing on the following controversial issues: (i) the diverse morphologic spectrum: 'the great simulator;' (ii) malignant transformation or dedifferentiation; (iii) current risk stratification systems; and (iv) molecular factors associated with cl…