Search results for "rats"
showing 10 items of 3537 documents
Les conséquences de la privatisation et de la commercialisation des activités spatiales sur les pratiques des contractants
2004
International audience
Magistrats, policiers et gendarmes en France à la Belle Époque : enquête sur les relations entre les acteurs de l'enquête de police judiciaire
2005
International audience; Les enquêtes ne sont qu'un moment de la police judiciaire qui « recherche les crimes, les délits et les contraventions, en rassembles les preuves et en livre les auteurs aux tribunaux chargés de les punir ». Ce moment met en scène, simultanément ou successivement, concomitamment ou séparément, magistrats du Parquet, juges d'instruction, policiers et gendarmes - pour ses acteurs les plus notables - et instaure une unité dramatique privilégiée pour saisir leurs rapports. Mais, s'ils poursuivent le même objectif assigné, ces protagonistes mettent en œuvre des cultures et des pratiques professionnelles dissemblables. Prescrite par le Code d'instruction criminelle, la coe…
Suuren Pohjan sodan jälkeen Hämeeseen siirretyt ruotsalaissotilaat noin vuoteen 1760
2015
Cloning and Targeted Deletion of the Mouse Fetuin Gene
1998
We proposed that the alpha2-Heremans Schmid glycoprotein/fetuin family of serum proteins inhibits unwanted mineralization. To test this hypothesis in animals, we cloned the mouse fetuin gene and generated mice lacking fetuin. The gene consists of seven exons and six introns. The cystatin-like domains D1 and D2 of mouse fetuin are encoded by three exons each, whereas a single terminal exon encodes the carboxyl-terminal domain D3. The promoter structure is well conserved between rat and mouse fetuin genes within the regions shown to bind transcription factors in the rat system. Expression studies demonstrated that mice homozygous for the gene deletion lacked fetuin protein and that mice heter…
Rat tyrosine kinase inhibitor shows sequence similarity to human α2-HS glycoprotein and bovine fetuin
1991
Human alpha 2-HS glycoprotein and bovine fetuin, abundant proteins of fetal plasma, are structural members of the fetuin family within the cystatin superfamily. They are characterized by the presence of two N-terminally located cystatin-like units and a unique C-terminal sequence segment not present in the other members of the cystatin superfamily. Search for related sequences revealed that the natural inhibitor of the insulin receptor tyrosine kinase [Auberger, Falquerho, Contreres, Pages, Le Cam, Rossi & Le Cam (1989) Cell (Cambridge, Mass.) 58, 631-640] shows sequence similarity to the mammalian fetuins. The sequence identity between rat tyrosine kinase inhibitor, human alpha 2-HS gl…
Long-Term Potentiation in the Neonatal Rat Barrel Cortex In Vivo
2012
Long-term potentiation (LTP) is important for the activity-dependent formation of early cortical circuits. In the neonatal rodent barrel cortex, LTP has been studied only in vitro . We combined voltage-sensitive dye imaging with extracellular multielectrode recordings to study whisker stimulation-induced LTP in the whisker-to-barrel cortex pathway of the neonatal rat barrel cortex in vivo . Single whisker stimulation at 2 Hz for 10 min induced an age-dependent expression of LTP in postnatal day (P) 0 to P14 rats, with the strongest expression of LTP at P3–P5. The magnitude of LTP was largest in the activated barrel-related column, smaller in the surrounding septal region, and no LTP could b…
Abnormal peripubertal development of the rat mammary gland following exposure in utero and during lactation to a mixture of genistein and the food co…
2012
The impact of early exposure to endocrine disruptor mixtures on mammary gland development is poorly known. Here, we identify the effects of a conception to weaning exposure of rats to the phytoestrogen genistein (G) and/or the antiandrogen vinclozolin (V) at 1 mg/kg-d, alone or in association. Using several approaches, we found that G- and GV-exposed rats displayed significantly greater epithelial branching and proliferation, wider terminal end buds than controls at PND35, as well as ductal hyperplasia and periductal fibrosis. Focal branching defects were present in V-exposed rats. An increased ER and AR expression was observed in G- and CV- as compared to V-exposed rats at PND35. Surprisin…
Aproximació historicoanalítica a la música de José Antonio Valls Subirats (1958-1983)
2022
OBJECTIUS: Aquesta tesi doctoral té els següents objectius generals: (1) estudiar la influència musical dels jesuïtes a Tortosa, com a seu del bisbat de Tortosa, que incorpora el poble d’Alcanar, des de la fi del segle XIX fins a la primera meitat del segle XX; (2) recuperar la producció de José Antonio Valls Subirats (1958-1983), natural d’Alcanar; i (3) determinar el llenguatge i la «poesi» d’aquest compositor. Com a objectius específics, es realitzaran les tasques següents: dintre de l’objectiu general núm. 2, es farà una panoràmica de la vida i l’obra de José Antonio Valls Subirats; i dintre de l’objectiu general núm. 3, (a) es realitzarà una anàlisi estilística de tota la seva producci…
Toward evidence-based severity assessment in rat models with repeated seizures: II. Chemical post-status epilepticus model.
2019
Objective: Considering the complexity of neuronal circuits and their epilepsy-associated alterations, epilepsy models cannot be completely replaced by in vitro experimental approaches. Decisions about ethical approval of in vivo studies require a thorough weighing of the animal's burden and the benefit regarding the expected gain in knowledge. Methods: Based on combined behavioral, biochemical, and physiological analyses, we assessed the impact on animal well-being and condition in different phases of the pilocarpine post–status epilepticus (SE) model in rats. Results: As a consequence of SE, increased levels of impairment were evident in the early postinsult phase and late chronic phase, w…
Yeast Killer Toxin-Like Candidacidal Ab6 Antibodies Elicited through the Manipulation of the Idiotypic Cascade
2014
A mouse anti-anti-anti-idiotypic (Id) IgM monoclonal antibody (mAb K20, Ab4), functionally mimicking a Wyckerhamomyces anomalus (Pichia anomala) killer toxin (KT) characterized by fungicidal activity against yeasts presenting specific cell wall receptors (KTR) mainly constituted by β-1,3-glucan, was produced from animals presenting anti-KT Abs (Ab3) following immunization with a rat IgM anti-Id KT-like mAb (mAb K10, Ab2). MAb K10 was produced by immunization with a KT-neutralizing mAb (mAb KT4, Ab1) bearing the internal image of KTR. MAb K20, likewise mAb K10, proved to be fungicidal in vitro against KT-sensitive Candida albicans cells, an activity neutralized by mAb KT4, and was capable of…