Search results for "real-time"

MicroRNA-30d deficiency during preconception affects endometrial receptivity by decreasing implantation rates and impairing fetal growth.

2019

Background Maternal–embryonic crosstalk between the endometrium and the preimplantation embryo is required for normal pregnancy. Our previous results demonstrated that maternal microRNAs secreted into the endometrial fluid, specifically miR-30d, act as a transcriptomic regulator of the preimplantation embryo by the maternal intrauterine environment. Objective To investigate the reproductive and fetal effects of murine miR-30d deficiency at the maternal–embryonic interface according to the origin of its maternal or embryonic default. Study Design A miR-30d knockout murine model was used as the animal model to investigate the impact of maternal and/or embryonic origin of miR-30d deficiency on…

On the hardness of evaluating criticality of activities in a planar network with duration intervals

2003

Complexity results for problems of evaluating the criticality of activities in planar networks with duration time intervals are presented. We show that the problems of asserting whether an activity is possibly critical, and of computing bounds on the float of an activity in these networks are NP-complete and NP-hard, respectively.

Combining hectometric and decametric satellite observations to provide near real time decametric FAPAR product

2017

Abstract A wide range of ecological, agricultural, hydrological and meteorological applications at local to regional scales requires decametric biophysical data. However, before the launch of SENTINEL-2A, only few decametric products are produced and most of them remain limited by the small number of available observations, mostly due to a moderate revisit frequency combined with cloud occurrence. Conversely, kilometric and hectometric biophysical products are now widely available with almost complete and continuous coverage, but the associated spatial resolution limits the application over heterogeneous landscapes. The objective of this study is to combine unfrequent decametric spatial res…

Quantitative DNA Analyses for Airborne Birch Pollen

2015

Birch trees produce large amounts of highly allergenic pollen grains that are distributed by wind and impact human health by causing seasonal hay fever, pollen-related asthma, and other allergic diseases. Traditionally, pollen forecasts are based on conventional microscopic counting techniques that are labor-intensive and limited in the reliable identification of species. Molecular biological techniques provide an alternative approach that is less labor-intensive and enables identification of any species by its genetic fingerprint. A particularly promising method is quantitative Real-Time polymerase chain reaction (qPCR), which can be used to determine the number of DNA copies and thus poll…

A multiplex polymerase chain reaction protocol for the simultaneous analysis of the glutathione S-transferase GSTM1 and GSTT1 polymorphisms.

1996

Brief communication: Vehicle routing problem and UAV application in the post-earthquake scenario

2017

Abstract. In this paper we simulate a Unmanned Aerial Vehicle's (UAV) recognition after a possible case of diffuse damage after a seismic event in the town of Acireale (Sicily, Italy). Given a set of sites (84 relevant buildings) and the range of the UAV, we are able to find the number of vehicles to employ and the shortest survey path. The problem of finding the shortest survey path is an operational research problem called Vehicle Routing Problem (VRP) whose solution is known to be computationally time-consuming. We used the Simulated Annealing (SA) heuristic that is able to provide stable solutions in relatively short computing time. We also examined the distribution of the cost of the s…

Smart grid-aware scheduling in data centres

2015

In several countries the expansion and establishment of renewable energies result in widely scattered and often weather-dependent energy production, decoupled from energy demand. Large, fossil-fuelled power plants are gradually replaced by many small power stations that transform wind, solar and water power into electrical power. This leads to changes in the historically evolved power grid that favours top-down energy distribution from a backbone of large power plants to widespread consumers. Now, with the increase of energy production in lower layers of the grid, there is also a bottom-up flow of the grid infrastructure compromising its stability. In order to locally adapt the energy deman…

Hyplets - Multi Exception Level Kernel towards Linux RTOS

2018

This paper presents the concept of a Multi-Exception level operating system. We add a hypervisor awareness to the Linux kernel and execute code in hyp exception level. We do that through the use of Hyplets. Hyplets are an innovative way to code interrupt service routines under ARM. Hyplets provide high performance, security, running time predictability, an RPC mechanism and a possible solution for the priority inversion problem. Hyplets uses special features of ARM8va hypervisor memory architecture.

Highlighting Curcumin-Induced Crosstalk between Autophagy and Apoptosis as Supported by Its Specific Subcellular Localization

2020

Curcumin, a major active component of turmeric (Curcuma longa, L.), is known to have various effects on both healthy and cancerous tissues. In vitro studies suggest that curcumin inhibits cancer cell growth by activating apoptosis, but the mechanism underlying the anticancer effect of curcumin is still unclear. Since there is a recent consensus about endoplasmic reticulum (ER) stress being involved in the cytotoxicity of natural compounds, we have investigated using Image flow cytometry the mechanistic aspects of curcumin&rsquo

Establishing PNB-qPCR for quantifying minimal ctDNA concentrations during tumour resection.

2017

The analysis of blood plasma or serum as a non-invasive alternative to tissue biopsies is a much-pursued goal in cancer research. Various methods and approaches have been presented to determine a patient’s tumour status, chances of survival, and response to therapy from serum or plasma samples. We established PNB-qPCR (Pooled, Nested, WT-Blocking qPCR), a highly specific nested qPCR with various modifications to detect and quantify minute amounts of circulating tumour DNA (ctDNA) from very limited blood plasma samples. PNB-qPCR is a nested qPCR technique combining ARMS primers, blocking primers, LNA probes, and pooling of multiple first round products for sensitive quantification of the sev…