Search results for "rection"

Entrapment of an EGFR inhibitor into nanostructured lipid carriers (NLC) improves its antitumor activity against human hepatocarcinoma cells

2014

Background: In hepatocellular carcinoma (HCC), different signaling pathways are de-regulated, and among them, the expression of the epidermal growth factor receptor (EGFR). Tyrphostin AG-1478 is a lipophilic low molecular weight inhibitor of EGFR, preferentially acting on liver tumor cells. In order to overcome its poor drug solubility and thus improving its anticancer activity, it was entrapped into nanostructured lipid carriers (NLC) by using safe ingredients for parenteral delivery. Results: Nanostructured lipid carriers (NLC) carrying tyrphostin AG-1478 were prepared by using the nanoprecipitation method and different matrix compositions. The best system in terms of mean size, PDI, zeta…

Novo, S. et al. Aliskiren: Just a New Drug for Few Selected Patients or an Innovative Molecule Predestinated to Replace Arbs and Ace-Inhibitors? Phar…

2011

The renin-angiotensin-aldosterone system (RAAS) plays a dominant role in the pathophysiology of hypertension, diabetes mellitus, chronic kidney disease and chronic heart failure. Therefore, drugs that block key components of the RAAS such as ACE inhibitors (ACEI) and angiotensin receptor blockers (ARBs) have gained wide clinical use for these indications. Despite progress, the morbidity and mortality of patients treated with ACEI or ARBs remain high. Aliskiren (Tekturna, Rasilez) is the first orally active inhibitor of renin approved for clinical use as an antihypertensive agent. The development program has established that at the licensed doses of 150 mg and 300 mg. Aliskiren is effective …

Mode-superposition correction method for deterministic and stochastic analysis of structural systems

2001

The role played by the modal analysis in the framework of structural dynamics is fundamental from both deterministic and stochastic point of view. However the accuracy obtained by means of the classical modal analysis is not always satisfactory. Therefore it is clear the importance of methods able to correct the modal response in such a way to obtain the required accuracy. Many methods have been proposed in the last years but they are meaningful only when the forcing function is expressed by an analytical function. Moreover in stochastic analysis they fail for white noise excitation. In the paper a method able to give a very accurate response for both deterministic and stochastic input is p…

L’auto-évaluation au service du développement professionnel des personnels de direction stagiaires

2022

Déterminants d'accès aux fonctions de direction, déroulement des carrières et rapport à l'exercice de la profession

1999

International audience

Unveiling the strong interaction among hadrons at the LHC

2020

One of the key challenges for nuclear physics today is to understand from first principles the effective interaction between hadrons with different quark content. First successes have been achieved using techniques that solve the dynamics of quarks and gluons on discrete space-time lattices1,2. Experimentally, the dynamics of the strong interaction have been studied by scattering hadrons off each other. Such scattering experiments are difficult or impossible for unstable hadrons3–6 and so high-quality measurements exist only for hadrons containing up and down quarks7. Here we demonstrate that measuring correlations in the momentum space between hadron pairs8–12 produced in ultrarelativistic…

Data service platform for sentinel-2 surface reflectance and value-added products: System use and examples

2016

This technical note presents the first Sentinel-2 data service platform for obtaining atmospherically-corrected images and generating the corresponding value-added products for any land surface on Earth (http://s2.boku.eodc.eu/). Using the European Space Agency’s (ESA) Sen2Cor algorithm, the platform processes ESA’s Level-1C top-of-atmosphere reflectance to atmospherically-corrected bottom-of-atmosphere (BoA) reflectance (Level-2A). The processing runs on-demand, with a global coverage, on the Earth Observation Data Centre (EODC), which is a public-private collaborative IT infrastructure in Vienna (Austria) for archiving, processing, and distributing Earth observation (EO) data (http://www.…

Gradient-Based Automatic Lookup Table Generator for Radiative Transfer Models

2022

Physically based radiative transfer models (RTMs) are widely used in Earth observation to understand the radiation processes occurring on the Earth’s surface and their interactions with water, vegetation, and atmosphere. Through continuous improvements, RTMs have increased in accuracy and representativity of complex scenes at expenses of an increase in complexity and computation time, making them impractical in various remote sensing applications. To overcome this limitation, the common practice is to precompute large lookup tables (LUTs) for their later interpolation. To further reduce the RTM computation burden and the error in LUT interpolation, we have developed a method to automaticall…

Atmospheric components determination from ground-level measurements during the spectra Barax Campaigns (SPARC) field campaigns

2007

The Surface Processes and Ecosystem Changes Through Response Analysis (SPECTRA) Barrax Campaigns were validation campaigns developed in the framework of the SPECTRA mission in order to verify that the geophysical data products provided by satellite imagery are consistent with the measurements made by independent means. Two campaigns took place in Barrax, Spain, during the summers of 2003 and 2004. This paper presents the results of the characterization of the atmospheric composition from solar radiation, radiosoundings, and lidar measurements. Several potentially interesting situations involving atmospheric layers with different types of aerosols and water content are discussed. The presenc…

First results from the PROBA/CHRIS hyperspectral/multiangular satellite system over land and water targets

2005

The Project for On-Board Autonomy (PROBA) platform developed by the European Space Agency was launched on October 22, 2001. The instrument payload includes the Compact High Resolution Imaging Spectrometer (CHRIS). The coupled system provides high spatial resolution hyperspectral/multi-angular data, which represents a new-generation source of information for Earth observation purposes. The first results obtained from the preprocessing (noise removal and geometric/atmospheric correction) of two different datasets, collected over agricultural crops and inland waters, are presented in this letter. In situ measurements are used to assess the quality of the data and to validate the processing alg…