Search results for "recurrence"

showing 10 items of 1036 documents

On the order of indeterminate moment problems

2013

For an indeterminate moment problem we denote the orthonormal polynomials by P_n. We study the relation between the growth of the function P(z)=(\sum_{n=0}^\infty|P_n(z)|^2)^{1/2} and summability properties of the sequence (P_n(z)). Under certain assumptions on the recurrence coefficients from the three term recurrence relation zP_n(z)=b_nP_{n+1}(z)+a_nP_n(z)+b_{n-1}P_{n-1}(z), we show that the function P is of order \alpha with 0<\alpha<1, if and only if the sequence (P_n(z)) is absolutely summable to any power greater than 2\alpha. Furthermore, the order \alpha is equal to the exponent of convergence of the sequence (b_n). Similar results are obtained for logarithmic order and for more ge…

SequenceRecurrence relationMathematics - Complex VariablesGeneral MathematicsEntire functionMathematical analysisFunction (mathematics)Moment problemCombinatoricsMoment (mathematics)Mathematics - Classical Analysis and ODEsClassical Analysis and ODEs (math.CA)FOS: MathematicsExponentOrder (group theory)44A60 30D15Complex Variables (math.CV)MathematicsAdvances in Mathematics
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Metilazione del DNA in artrite reumatoide

2005

Lo stato di metilazione del DNA genomico e del gene PTHrP è stato valutato con tecniche molecolari e citogenetiche in artrite reumatoide (AR), patologia autoimmune caratterizzata anche da alta incidenza di linfomi e da ipercalcemia per overespressione del gene PTHrP. La metilazione del DNA, infatti, ha un ruolo critico nello sviluppo delle malattie neoplastiche; il gene PTHrP avendo tre promotori uno dei quali contiene un’isola CpG è un buon candidato per la deregolazione da alterato pattern di metilazione locale. Le indagini sulla metilazione genomica, condotte su DNA estratto da sangue periferico di pazienti e di donatori e amplificato in reazioni di Methylation-Sensitive Arbitrarily Prim…

Settore BIO/18 - Geneticainstead chromosomes of controls were almost uniformly decorated by brilliant grains. Studies on methylation of PTHrP gene promoter 2 performed on five CpG island internal sites using the Methylation-Sensitive Restriction Endonuclease Multiplex (MSREM)-PCR showed that one of the sites nearest the trascription starting point is heavy methylated in a significantly high number of RA patients. Thus RA seems to be characterized by genomewide hypomethylation associated with local hypermethylation like the most part of tumors. This result raises the possibility that susceptibility to lymphomas is related to abnormal DNA methylation levels and suggests the opportunity to evaluate the DNA methylation status in RA patientin fact the demethylating therapies together with diet and life style can act towards an increase of tumor risk. Future studies using a larger number of subjects could confirm these findings.Rheumatoid Arthritis (RA) is a chronic multisystem inflammatory disease characterized by high recurrence of lymphomas as well as hypercalcemia due to PTHrP overexpression. Because of DNA methylation plays a critical role in development of neoplasias we determined in RA patients the global DNA methylation status and local methylation pattern of the CpG island of one of the three promoters of PTHrP gene utilizing molecular and cytogenetic techniques. Investigations performed on DNA from peripheral blood of patients and donors amplified by Methylation-Sensitive Arbitrarily Primed (MeS-AP)-PCR indicated that RA is strongly associated with global DNA hypomethylation. Similarly chromosomal DNA methylation pattern analysis by indirect immunofluorescence technique with anti 5-methylcitosine antibody showed all peripheral lymphocyte metaphases from RA patients with chromosomes weakly fluorescent without discrete grain
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Anti-tumour necrosis factor monoclonal antibody treatment for ocular Behçet's disease [2]

2002

Settore MED/16 - ReumatologiaRecurrenceSettore MED/30 - Malattie Apparato VisivoAntirheumatic AgentsBehcet SyndromeRetinitisAntibodies MonoclonalInfliximab
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Role of prophylactic central neck dissection in cN0-papillary thyroid carcinoma: Results from a high-prevalence area

2016

BACKGROUND: Prophylactic, compartment-oriented central neck dissection (CND) for cN0 papillary thyroid carcinoma (PTC) is not widely practiced. We examined our results with this surgical approach. METHODS: A cohort of 158 patients operated on for the classical variant of PTC at a follow-up of 1-22 years (mean: 6.6) were enrolled. The patients with a preoperative diagnosis of cN0 PTC (group A, 59 patients) underwent total thyroidectomy (TT) + CND. In the patients with incidental postoperative diagnosis of malignancy (group B, 99 patients) a TT alone was performed. RESULTS: Ninety-six T1, 36 T2, 26 T3/T4 PTC patients were enrolled. The overall biochemical/scintigraphic recurrence rate (15 pat…

Settore MED/18 - Chirurgia GeneraleRecurrencePapillaryThyroidectomySurgeryNeck dissectionTherapeuticNeck dissection; Papillary; Recurrence; Therapeutics; Thyroid cancer; Thyroidectomy; SurgeryThyroid cancer
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FAILURE of TERATMENT in CHILDHOOD EXTRACRANIAL and EXTRATESTICULAR MALIGNANT GERM CELL TUMOURS (mgct)

2001

Platinum based chemptherapy improves the cure rate of patients with MGCT to over 80 poer cent, but tumour recurrence is associated with an unfavourable prognosis. We sought to identify factors predicitive of poor outcome following relapse.

Settore MED/38 - Pediatria Generale E SpecialisticaSettore MED/20 - Chirurgia Pediatrica E Infantilemalignant extracranial and extratesticular Germ Cel Tumors platonum chemotherapy recurrence
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Two Patients With History of STEC-HUS, Posttransplant Recurrence and Complement Gene Mutations

2013

Hemolytic uremic syndrome (HUS) is a disease of microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure. About 90% of cases are secondary to infections by Escherichia coli strains producing Shiga-like toxins (STEC-HUS), while 10% are associated with mutations in genes encoding proteins of complement system (aHUS). We describe two patients with a clinical history of STEC-HUS, who developed end-stage renal disease (ESRD) soon after disease onset. They received a kidney transplant but lost the graft for HUS recurrence, a complication more commonly observed in aHUS. Before planning a second renal transplantation, the two patients underwent genetic screening for aHUS-associat…

Shiga-toxinGraft RejectionMaleDNA Primer030232 urology & nephrologyEscherichia coli InfectionGene mutationurologic and male genital diseasesGastroenterology0302 clinical medicineRecurrenceRisk Factorshemic and lymphatic diseasesImmunology and AllergyPharmacology (medical)gene mutationKidney transplantationEscherichia coli Infections0303 health sciencesKidneymedicine.diagnostic_testShiga-Toxigenic Escherichia coliAntigens CD46Microangiopathic hemolytic anemiaMiddle AgedPrognosisfemale genital diseases and pregnancy complications3. Good healthPedigreemedicine.anatomical_structureComplement Factor IComplement factor I; gene mutation; hemolytic uremic syndrome; kidney transplantation; membrane cofactor protein; Shiga-toxin; Adult; Antigens CD46; Case-Control Studies; Complement Factor I; DNA Primers; Escherichia coli Infections; Female; Genetic Testing; Graft Rejection; Hemolytic-Uremic Syndrome; Heterozygote; Humans; Kidney Failure Chronic; Kidney Transplantation; Male; Middle Aged; Mutation; Pedigree; Prognosis; Recurrence; Risk Factors; Shiga-Toxigenic Escherichia coli; Thrombocytopenia; Young Adult; Transplantation; Immunology and Allergy; Pharmacology (medical)FemaleCase-Control StudieHumanAdultmedicine.medical_specialtyHeterozygotePrognosiComplement factor IMembrane Cofactor Protein03 medical and health sciencesYoung AdultInternal medicinemedicineHumansGenetic Testing030304 developmental biologyGenetic testingDNA PrimersTransplantationbusiness.industryCD46Risk Factormedicine.diseaseKidney TransplantationThrombocytopeniaTransplantationCase-Control StudiesImmunologyHemolytic-Uremic SyndromeMutationhemolytic uremic syndromeKidney Failure ChronicbusinessAmerican Journal of Transplantation
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High-order regularization in lattice-Boltzmann equations

2017

A lattice-Boltzmann equation (LBE) is the discrete counterpart of a continuous kinetic model. It can be derived using a Hermite polynomial expansion for the velocity distribution function. Since LBEs are characterized by discrete, finite representations of the microscopic velocity space, the expansion must be truncated and the appropriate order of truncation depends on the hydrodynamic problem under investigation. Here we consider a particular truncation where the non-equilibrium distribution is expanded on a par with the equilibrium distribution, except that the diffusive parts of high-order nonequilibrium moments are filtered, i.e., only the corresponding advective parts are retained afte…

Shock waverecurrence relationspolynomialsComputational MechanicsLattice Boltzmann methods114 Physical sciences01 natural sciences010305 fluids & plasmassubspaces0103 physical sciences010306 general physicsFluid Flow and Transfer ProcessesPhysicstensor methods: shock tubesHermite polynomialsRecurrence relationta114AdvectionMechanical EngineeringpolynomitMathematical analysisCondensed Matter PhysicsDistribution functionMechanics of MaterialsRegularization (physics)shock tubes [tensor methods]Shear flowPhysics of Fluids
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Effectiveness of clinical and instrumental follow-up for cutaneous melanoma

2022

Introduction: Follow-up guidelines for melanoma greatly differ in the methods of screening for recurrence, and timing and duration of the follow up, with many areas of controversy and a lack of general consensus. The aims of this study are to present our protocol and case series for follow up and to summarize and discuss current literature on melanoma follow-up guidelines/recommendations in different countries. Methods: We retrospectively reviewed 539 patients operated for melanoma between 2004 and 2013 at the same Institution. Data on the diagnostic role of the different clinical and instrumental detection methods were adjusted for sex, age at diagnosis, staging and evaluated by Fisher's e…

Skin NeoplasmsOncologyRecurrenceHumansSurgeryFollow-up Local recurrences Melanoma Metastases Prognosis Surgical oncologyNeoplasm Recurrence LocalMelanomaFollow-Up StudiesNeoplasm StagingRetrospective StudiesSurgical Oncology
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Monoclonal gammopathy of ocular significance (MGOS) – a short survey of corneal manifestations and treatment outcomes

2021

Monoclonal gammopathy of ocular significance (MGOS) is a rare subset of monoclonal gammopathy of clinical significance occurring secondary to plasma cell disorders and causing ocular manifestations. We identified 23 patients with paraproteinemic keratopathy (PPK) in the setting of monoclonal gammopathy of unknown significance (MGUS, 10), smoldering multiple myeloma (SMM, 3) or multiple myeloma (MM, 10). Many of these patients with PPK (11/23) presented decreased vision. All patients with MM and 40% of those with other diagnoses such as SMM and MGUS received systemic therapy with or without autologous stem cell transplantation. Four eyes of four patients were treated by penetrating keratopla…

Smoldering Multiple MyelomaCancer Researchmedicine.medical_specialtyVisual acuitygenetic structuresMonoclonal gammopathy of clinical significancemonoclonal gammopathy of ocular significanceTreatment outcomeParaproteinemiasPlasma cellMonoclonal Gammopathy of Undetermined SignificanceTransplantation AutologousSystemic therapyGastroenterologyMonoclonal gammopathy of clinical significance; monoclonal gammopathy of ocular significance; multiple myeloma; paraproteinemic keratopathyCorneal DiseasesAutologous stem-cell transplantationhemic and lymphatic diseasesInternal medicinemedicineHumansClinical significanceMultiple myelomabusiness.industryHematopoietic Stem Cell TransplantationHematologymedicine.diseaseeye diseasesMonoclonal gammopathyparaproteinemic keratopathyTreatment Outcomemedicine.anatomical_structureOncologyNeoplasm Recurrence Localmedicine.symptomMultiple MyelomabusinessLeukemia &amp; Lymphoma
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Recurrence of hepatocellular carcinoma after liver transplantation: an update.

2015

Liver transplantation is the only curative alternative for selected patients with hepatocellular carcinoma (HCC) who are not eligible for resection and/or with decompensated cirrhosis. According to Milan criteria the 5-year survival rate is 70–85%, with a recurrence-free survival of 75%. However, HCC recurrence rate after liver transplantation remains a significant problem in the clinical practice. The prognosis in patients with HCC recurrence is poor. The treatment of choice for HCC recurrence is surgery, but it seems that a systemic treatment based on combination of an mTOR inhibitor with sorafenib can be used. Data on safety and efficacy are limited, clinical monitoring is necessary. Th…

SorafenibOncologyCancer Researchmedicine.medical_specialtyrecurrenceCarcinoma Hepatocellularmedicine.medical_treatmentliving donorLiver transplantationMilan criteriaGastroenterologyLeukocyte CountRisk FactorsInternal medicinemedicineBiomarkers TumorCombined Modality TherapyHumansalpha-FetoproteinPerioperative PeriodSurvival rateimmunosuppressionbusiness.industryRisk FactorLiver NeoplasmsImmunosuppressionGeneral MedicinePerioperativehepatocellular carcinomamedicine.diseaseCombined Modality Therapydigestive system diseasesLiver TransplantationTumor BurdenOncologyLiver NeoplasmHepatocellular carcinomaalpha-FetoproteinsNeoplasm Recurrence Localbusinessmedicine.drugHumanFuture oncology (London, England)
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