Search results for "recurrence"

showing 10 items of 1036 documents

Impact of margin status on long-term results of liver resection for hepatocellular carcinoma: single-center time-to-recurrence analysis

2020

Occult metastasis from the initial tumor and a de novo second primary hepatocellular carcinoma (HCC) were recognized as the main causes for the onset of early and late HCC recurrence, after liver resection (LR). This study aims to compare the time to recurrence after LR for HCC in which a margin ≤ 1 mm or > 1 mm was achieved. A single-center retrospective study involving 256 patients was conducted from June 2005 to June 2019. HCC patients resected with a radical surgical approach were investigated and stratified into groups A (resection margins ≤ 1 mm) and B (> 1 mm), as measured on final pathologic assessment. Kaplan–Meier estimators were used to estimate the probability of recurrenc…

medicine.medical_specialtyCarcinoma HepatocellularTime FactorsHepatocellular carcinomaHepatocellular carcinoma; Liver resection; Liver transplantation; Margin status; Outcome030230 surgerySingle CenterGastroenterologyGroup BMetastasis03 medical and health sciences0302 clinical medicineInternal medicineHepatocellular carcinoma Liver resection Liver transplantation Margin status Outcome Carcinoma Hepatocellular Liver Neoplasms Neoplasm Recurrence Local Neoplasms Second Primary Time Factors Hepatectomy Margins of ExcisionEpidemiologyHepatectomyHumansMedicineMargin statusPathologicalOutcomeLiver transplantationLiver resectionbusiness.industryProportional hazards modelLiver NeoplasmsMargins of ExcisionNeoplasms Second PrimaryRetrospective cohort studymedicine.diseaseSurgery030220 oncology & carcinogenesisHepatocellular carcinomaSurgeryNeoplasm Recurrence Localbusiness
researchProduct

Transarterial Chemoembolization Before Liver Transplantation in 60 Patients With Hepatocellular Carcinoma

2007

Tumor recurrence is a major problem after orthotopic liver transplantation (OLT) in patients with hepatocellular carcinoma (HCC). In 60 patients OLT was performed for HCC after pretreatment by repeated transarterial chemoembolization (TACE). Forty-four recipients exceeded the Milan criteria. Recurrence-free 5-year survival was 65.2% and 5-year freedom from recurrence was 73.2%. During the waiting time, 14 patients experienced minimal change, which did not fulfill the definition of tumor progression according to official oncological criteria. Five-year freedom from recurrence among patients with stable compared with progressive disease was 93.3% versus 28.1%, respectively (P = .0001). A stri…

medicine.medical_specialtyCarcinoma HepatocellularTime Factorsmedicine.medical_treatmentLiver transplantationMilan criteriaGastroenterologyDisease-Free SurvivalRecurrenceInternal medicinePreoperative CaremedicineHumansEmbolizationChemoembolization TherapeuticTransplantationbusiness.industryPatient SelectionLiver Neoplasmsmedicine.diseaseSurvival AnalysisLiver TransplantationSurgeryTransplantationTumor progressionHepatocellular carcinomaSurgerybusinessLiver cancerProgressive diseaseTransplantation Proceedings
researchProduct

Long-term observation of hepatocellular carcinoma recurrence after liver transplantation at a European transplantation centre

2019

BACKGROUND: The recurrence of hepatocellular carcinoma (HCC) is the strongest survival-limiting factor after liver transplantation (LT) in patients with HCC. In the face of donor organ shortage, it is necessary to identify factors associated with HCC recurrence in order to maximize the utility of the available grafts. OBJECTIVE: To study the phenomenon of HCC recurrence after LT at a European transplantation centre over the past 20 years. METHODS: Data from 304 HCC patients who underwent LT were prospectively recorded. Clinical and pathological factors were assessed for their association with recurrence. RESULTS: Fifty-one patients (16.8%) had HCC recurrence after LT. Patients exceeding the…

medicine.medical_specialtyCarcinoma Hepatocellularmedicine.medical_treatmentEconomic shortageLiver transplantationGastroenterology03 medical and health sciences0302 clinical medicineInternal medicinemedicineHumansIn patientneoplasmsProportional Hazards Modelsbusiness.industryLiver NeoplasmsGastroenterologyOriginal Articlesmedicine.diseasePrognosisdigestive system diseasesLiver TransplantationTransplantationEuropeTreatment OutcomeOncology030220 oncology & carcinogenesisHepatocellular carcinoma030211 gastroenterology & hepatologyNeoplasm Recurrence LocalbusinessLiver cancer
researchProduct

Pathologic response to preoperative transarterial chemoembolization for resectable hepatocellular carcinoma may not predict recurrence after liver re…

2016

medicine.medical_specialtyCarcinoma Hepatocellularmedicine.medical_treatmentTreatment outcomeResection03 medical and health sciences0302 clinical medicineText miningResectable Hepatocellular CarcinomamedicinePathologic ResponseHepatectomyHumansChemoembolization TherapeuticRetrospective StudiesHepatologybusiness.industryLiver NeoplasmsGastroenterologyRetrospective cohort studyTreatment Outcome030220 oncology & carcinogenesis030211 gastroenterology & hepatologyRadiologyHepatectomyNeoplasm Recurrence LocalbusinessHepatobiliarypancreatic diseases international : HBPD INT
researchProduct

Primary paraesophageal Ewing’s sarcoma: an uncommon case report and literature review

2015

Ewing’s sarcoma is a rare and highly aggressive cancer most frequently arising in people under 20 years of age. We report an uncommon case of primary paraesophageal Ewing’s sarcoma in a 25-year-old male harboring the infrequent EWSR1/ERG fusion transcript with multiple splice variants coexisting in the same tumor. The patient was totally refractory to chemotherapy and died 17 months after diagnosis. We underscore the need for better understanding of the molecular pathogenesis of the disease and improved systemic therapy options.

medicine.medical_specialtyChemotherapyPathologyrecurrenceParaesophagealbusiness.industrymedicine.medical_treatmentMolecular pathogenesisEwing's sarcomaCase ReportDiseasemedicine.diseaseDermatologySystemic therapyOncologyFusion transcriptimmunohistochemistryMedicinePharmacology (medical)SarcomaEwing’s sarcomabusinessfusion genesOncoTargets and Therapy
researchProduct

The treatment of portal hypertension: a meta-analytic review.

1995

medicine.medical_specialtyClinical Trials as TopicHepatologybusiness.industryVascular diseaseMEDLINEHemorrhageVariceal hemorrhagemedicine.diseaseGastroesophageal variceslaw.inventionSurgeryVaricose VeinsText miningRandomized controlled triallawRecurrenceRisk FactorsMeta-analysisHypertension PortalmedicinePortal hypertensionHumansIntensive care medicinebusinessHepatology (Baltimore, Md.)
researchProduct

Role of fluorine 18 fluorodeoxyglucose positron emission tomography/computed tomography in gastrointestinal cancers

2015

AbstractFluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) has become a routine imaging modality for many malignancies and its use is currently increasing. In the present review article, we will summarize the evidence for FDG-PET/CT use in digestive cancers (excluding neuroendocrine tumours), and review the existing recommendations. While PET/CT is nowadays considered to be an important tool in the initial workup of oesophageal and anal cancers, new data are emerging regarding its use in assessing therapeutic efficacy, radiotherapy treatment planning, and detection of recurrence in case of isolated tumour marker elevation. Moreover, PET/CT may help …

medicine.medical_specialtyColorectal cancerColonoscopyDigestive System NeoplasmsMultimodal ImagingPatient Care PlanningFluorodeoxyglucose positron emission tomographyFluorodeoxyglucose F18Pancreatic cancerHumansMedicinePositron Emission Tomography-Computed TomographyFluorine-18-fluorodeoxyglucoseHepatologymedicine.diagnostic_testbusiness.industryOesophageal cancerGastroenterologyPancreatic cancerRadiotherapy treatment planningPrognosismedicine.diseaseColorectal cancerFDG-PET/CTAnal canal cancerReview articleNeuroendocrine TumorsPositron-Emission TomographyPractice Guidelines as TopicRadiologyNeoplasm Recurrence LocalRadiopharmaceuticalsTomography X-Ray ComputedbusinessDigestive and Liver Disease
researchProduct

A systematic review and meta-analysis comparing surgical and oncological outcomes of upper rectal, rectosigmoid and sigmoid tumours.

2021

Abstract Aim Management paradigms for tumours from the sigmoid colon to the lower rectum vary significantly. The upper rectum (UR) represents the transition point both anatomically and in treatment protocols. Above the UR is clearly defined and managed as colon cancer and below is managed as rectal cancer. This study compares outcomes between sigmoid, rectosigmoid and UR tumours to establish if differences exist in operative and oncological outcomes. Methods Electronic databases were searched for published studies with comparative data on peri-operative and oncological outcome for upper rectal and sigmoid/rectosigmoid (SRS) tumours treated without neoadjuvant radiation. The search adhered t…

medicine.medical_specialtyColorectal cancermedicine.medical_treatmentHealth StatusRectumAnastomotic LeakAnastomosis03 medical and health sciences0302 clinical medicinemedicineHumansNeoplasm MetastasisIntraoperative ComplicationsLymph nodeNeoplasm Stagingbusiness.industryRectal NeoplasmsRectumSigmoid colonCancerGeneral Medicinemedicine.diseaseRadiation therapySurvival RateSigmoid Neoplasmsmedicine.anatomical_structureTreatment OutcomeOncology030220 oncology & carcinogenesisMeta-analysisLymphatic Metastasis030211 gastroenterology & hepatologySurgeryRadiologyNeoplasm GradingNeoplasm Recurrence LocalbusinessEuropean journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
researchProduct

Protective Role of Conization Before Radical Hysterectomy in Early-Stage Cervical Cancer: A Propensity-Score Matching Study.

2021

Purpose: The purpose of this study was to assess the prognostic role and the perioperative outcomes of conization performed before radical hysterectomy in early-stage cervical carcinoma. Methods: This multicenter, retrospective observational cohort study included patients with FIGO 2009 stage IB1 cervical carcinoma treated with radical hysterectomy between June 2004 and June 2019. Patients were divided into two groups according to conization before radical surgery. One-to-one case–control matching was used to adjust the baseline characteristics. Results: A total of 332 patients were included after propensity matching (166, 50% in each group). Twenty-four of 166 (14.4%) and 142 of 166 (85.6%…

medicine.medical_specialtyConizationUterine Cervical NeoplasmsHysterectomy03 medical and health sciences0302 clinical medicineMedicineHumansRisk factorStage (cooking)Radical surgeryRadical HysterectomyNeoplasm StagingRetrospective StudiesCervical cancerbusiness.industryPerioperativemedicine.diseaseSurgeryNeoplasm RecurrenceSettore MED/40 - GINECOLOGIA E OSTETRICIALocalOncology030220 oncology & carcinogenesisPropensity score matchingCervical cancer030211 gastroenterology & hepatologySurgeryFemaleNeoplasm Recurrence LocalbusinessCohort studyAnnals of surgical oncologyREFERENCES
researchProduct

Laparoscopic laterally extended pelvic resection for gynecological malignancies

2020

Lateral isolated gynecological cancer infiltrating the pelvic side wall has been considered non-operable with a poor oncological outcome.[1][1] The development of the laterally extended endopelvic resection and surgical progress for disease, overcoming the endopelvic fascia infiltrating muscles and

medicine.medical_specialtyCystadenocarcinomaLaparoscopesResection03 medical and health sciencesGynecologic Surgical Procedures0302 clinical medicinelaparoscopeGynecologic Surgical ProcedurelocalmedicineHumansAgedEndopelvic fasciaOvarian Neoplasms030219 obstetrics & reproductive medicineneoplasm recurrence localbusiness.industrySerousObstetrics and Gynecologyneoplasm recurrencemedicine.diseaseGynecological cancerCystadenocarcinoma SerousSurgerybody regionsCystadenocarcinoma SeroulaparoscopesSettore MED/40 - GINECOLOGIA E OSTETRICIAovarian cancerOncology030220 oncology & carcinogenesisFemaleLaparoscopybusinessOvarian cancer
researchProduct