Search results for "recurso"

A (1->3)-beta-D-glucan recognition protein from the sponge Suberites domuncula. Mediated activation of fibrinogen-like protein and epidermal growth f…

2004

Sponges (phylum Porifera) live in a symbiotic relationship with microorganisms, primarily bacteria. Until now, molecular proof for the capacity of sponges to recognize fungi in the surrounding aqueous milieu has not been available. Here we demonstrate, for the demosponge Suberites domuncula (Porifera, Demospongiae, Hadromerida), a cell surface receptor that recognizes (1--3)-beta-D-glucans, e.g. curdlan or laminarin. This receptor, the (1--3)-beta-D-glucan-binding protein, was identified and its cDNA analysed. The gene coding for the 45 kDa protein was found to be upregulated in tissue after incubation with carbohydrate. Simultaneously with the increased expression of this gene, two further…

The effects of α-secretase ADAM10 on the proteolysis of neuregulin-1

2009

Although ADAM10 is a major alpha-secretase involved in non-amyloidogenic processing of the amyloid precursor protein, several additional substrates have been identified, most of them in vitro. Thus, therapeutical approaches for the prevention of Alzheimer's disease by upregulation of this metalloproteinase may have severe side effects. In the present study, we examined whether the ErbB receptor ligand neuregulin-1, which is essential for myelination and other important neuronal functions, is cleaved by ADAM10. Studies with beta- and gamma-secretase inhibitors, as well as with the metalloproteinase inhibitor GM6001, revealed an inhibition of neuregulin-1 processing in human astroglioma cell …

Alpha-secretase activation--an approach to Alzheimer's disease therapy.

2006

The nonamyloidogenic pathway of processing the amyloid precursor protein (APP) involves the cleavage within the amyloid-beta peptide sequence, and thus precludes amyloid-beta formation. The identification of a member of the disintegrin and metalloproteinase family, ADAM10, as an alpha-secretase that prevents plaque formation and hippocampal deficits in vivo gave us the possibility to examine the alpha-secretase as a potential target for the therapy of Alzheimer's disease. Within the priority program Cellular Mechanisms of Alzheimer's Disease, we investigated several approaches to stimulate the alpha-secretase pathway. Two protein convertases were found to be responsible for the removal of t…

The Role of the anti-amyloidogenic secretase ADAM10 in shedding the APP-like proteins.

2011

ADAM10 (A disintegrin and metalloproteinase 10) has been demonstrated as an enzyme with protective properties in Alzheimer's disease: in mouse models it not only lowered generation of toxic A-beta peptides and formation of senile plaques but also alleviated learning deficits and enhanced synaptic density. This is due to cleavage of the amyloid precursor protein (APP) within its A-beta stretch and to the release of the extracellular domain of APP with neuroprotective function. Aside from cleaving APP, ADAM10 has been linked to over 40 putative substrates at least in cell culture. These substrates are connected with important cellular functions such as cell migration, stress response and tran…

The Non-Amyloidogenic Pathway: Structure and Function of α-Secretases

2006

The amyloid cascade hypothesis is the most accepted explanation for the pathogenesis of Alzheimer’s disease (AD). APP is the precursor of the amyloid β peptide (Aβ), the principal proteinaceous component of amyloid plaques in brains of Alzheimer’s disease patients. Proteolytic cleavage of APP by the α-secretase within the Aβ sequence precludes formation of amyloidogenic peptides and leads to a release of soluble APPsα which has neuroprotective properties. In several studies, a decreased amount of APPsα in the cerebrospinal fluid of AD patients has been observed. Three members of the ADAM family (a disintegrin and metalloproteinase) ADAM-10, ADAM-17 (TACE) and ADAM-9 have been proposed as α-…

P3‐271: Presenilin‐1 (PS1) and amyloid precursor protein (APP) mutations present in mouse models of Alzheimer's disease in their response to γ‐secret…

2009

Funcionamiento neurocognitivo y psicosocial de pacientes con trastorno bipolar en una unidad de salud mental

2018

INTRODUCCION: Existe evidencia de que los pacientes que padecen Trastoro Bipolar (TB), e incluso sus familiares sanos, presentan patrones característicos de afectación de ciertos dominios neurocognitivos que persisten tras la remisión clínica o período de eutimia. La pérdida de funcionalidad psicosocial de estos pacientes se predice mejor con la presencia de alteraciones cognitivas que con variables clínicas o evolutivas. El clínico asistencial debería conocer si existe afectación o deterioro en las funciones neurocognitivas de sus pacientes pero en el medio asistencial cotidiano es difícil poder evaluar adecuadamente las funciones cognitivas y tampoco se acostumbra a cuantificar la funcion…

Is Oxidative Stress the Link Between Cerebral Small Vessel Disease, Sleep Disruption, and Oligodendrocyte Dysfunction in the Onset of Alzheimer’s Dis…

2021

Oxidative stress is an early occurrence in the development of Alzheimer’s disease (AD) and one of its proposed etiologic hypotheses. There is sufficient experimental evidence supporting the theory that impaired antioxidant enzymatic activity and increased formation of reactive oxygen species (ROS) take place in this disease. However, the antioxidant treatments fail to stop its advancement. Its multifactorial condition and the diverse toxicological cascades that can be initiated by ROS could possibly explain this failure. Recently, it has been suggested that cerebral small vessel disease (CSVD) contributes to the onset of AD. Oxidative stress is a central hallmark of CSVD and is depicted as …

La investigación en Ciencias Laborales como una nueva dimensión del alumnado universitario. Una experiencia innovadora

2016

Profesorado del Grado de Relaciones Laborales y Recursos Humanos de la Universitat de València, se planteó en el curso 2013-2014, y dado que la titulación había pasado de Diplomatura a Grado, la necesidad de fomentar entre el alumnado la orientación investigadora, opción hasta dicho momento difícil de desarrollar. Por eso, a través del desarrollo del proyecto de innovación en dicho curso «Medios para la difusión de resultados de investigaciones en Ciencias Laborales», se creó una web (http://inveslab.blogs.uv.es/) en la que se recogieron los resultados obtenidos del mismo, un repositorio con los medios existentes para la difusión de los resultados de investigaciones en Ciencias Laborales. T…

El impacto de la crisis en el empleo público local: el caso del área metropolitana de Valencia

2014

Los ajustes derivados de actual proceso de consolidación fiscal en que se hallan las Administraciones Públicas españolas han golpeado con fuerza a un entramado institucional débil: el empleo público de los gobiernos locales de nuestro país, explicable tanto por la fragilidad sobre el terreno del sistema de mérito, como por la falta de aplicación efectiva de mecanismos de gestión. En este contexto y transcurridos ya cinco años de crisis económica se trata de dar cuenta, mediante datos agregados y de un estudio realizado en el marco del proyecto SAIS-AMV (“sostenibilidad social y ambiental en espacios metropolitanos: el caso del área metropolitana de Valencia”), de qué modo, mediante qué estr…