Search results for "recurso"
showing 10 items of 734 documents
Toma de decisiones gerenciales: una aproximación a través de simulación
2018
RESUMEN Las decisiones gerenciales relacionadas con las inversiones en el desarrollo de recursos estratégicos, constituyen un aspecto clave en la formulación de las estrategias organizativas, y dado el efecto que los recursos estratégicos tienen sobre el desempeño de la firma, se hace pertinente el estudio de este tipo de decisiones, que han sido definidas como una capacidad dinámica gerencial, concepto que se deriva de las capacidades dinámicas de tipo organizativo que permiten a una organización renovar sus competencias cuando son aplicadas, por analogía, a las capacidades de los directivos para gestionar los recursos y competencias organizativos. Al definir este tipo de decisiones como u…
A practical entry to β-aryl-β-alkyl amino alcohols: application to the synthesis of a potent BACE1 inhibitor
2012
The 1,2-addition of alkyl Grignard reagents to readily available N-tert-butanesulfinyl ketimines, bearing an α-silyloxy substituent, proceeds in high yields and excellent diastereocontrol. The utility of the present method was demonstrated by the synthesis, in enantiomerically pure form, of one recently disclosed β-secretase (BACE1) inhibitor.
Independent Generation of Aβ42 and Aβ38 Peptide Species by γ-Secretase
2008
Proteolytic processing of the amyloid precursor protein by beta- and gamma-secretase generates the amyloid-beta (Abeta) peptides, which are principal drug targets in Alzheimer disease therapeutics. gamma-Secretase has imprecise cleavage specificity and generates the most abundant Abeta40 and Abeta42 species together with longer and shorter peptides such as Abeta38. Several mechanisms could explain the production of multiple Abeta peptides by gamma-secretase, including sequential processing of longer into shorter Abeta peptides. A novel class of gamma-secretase modulators (GSMs) that includes some non-steroidal anti-inflammatory drugs has been shown to selectively lower Abeta42 levels withou…
Expanded micro-particles by supercritical antisolvent precipitation: Interpretation of results
2008
Abstract Supercritical antisolvent (SAS) micronization has been used to obtain nanoparticles and micro-particles of several kinds of materials. Sometimes hollow expanded micro-particles have also been obtained. This work is focused on the analysis of this last morphology. We organized literature data and our previous experiments and we added new experiments on previously tested compounds and on compounds never tested before. As a result, expanded micro-particles using several compounds belonging to different categories and precipitated from different solvents in laboratory and pilot scale plants were obtained with diameters between about 10 and 180 μm. They also showed different sub-structu…
El empleado como recurso operante en la cocreación de valor: aplicación al ámbito de salud
2023
En el contexto sanitario actual, la investigación de la cocreación de valor desde la perspectiva del marketing ha experimentado un aumento sostenido. Frow et al. (2016) destacan que la atención sanitaria representa un contexto de servicio importante para investigar la cocreación de valor debido al reconocimiento generalizado de la importancia de las actividades colaborativas entre los diversos actores en la obtención de resultados beneficiosos para la salud. Si bien la participación del paciente en el proceso de cocreación de valor ha recibido una considerable atención en la literatura reciente, la cocreación liderada por los empleados está notoriamente ausente. Sin embargo, Palumbo (2016) …
Photo-oxidation behaviour of micro- and nano-filled polypropylene: effect of the filler type and compatibilizer precursor
2011
Epigenetic involvement in Hutchinson-Gilford progeria syndrome: a mini-review.
2013
Hutchinson-Gilford progeria syndrome (HGPS) is a rare human genetic disease that leads to a severe premature ageing phenotype, caused by mutations in the <i>LMNA</i> gene. The <i>LMNA</i> gene codes for lamin-A and lamin-C proteins, which are structural components of the nuclear lamina. HGPS is usually caused by a de novo <i>C1824T</i> mutation that leads to the accumulation of a dominant negative form of lamin-A called progerin. Progerin also accumulates physiologically in normal ageing cells as a rare splicing form of lamin-A transcripts. From this perspective, HGPS cells seem to be good candidates for the study of the physiological mechanisms of ageing…
Sp1 transcription factor interaction with accumulated prelamin a impairs adipose lineage differentiation in human mesenchymal stem cells: essential r…
2012
Abstract Lamin A (LMNA)-linked lipodystrophies may be either genetic (associated with LMNA mutations) or acquired (associated with the use of human immunodeficiency virus protease inhibitors [PIs]), and in both cases they share clinical features such as anomalous distribution of body fat or generalized loss of adipose tissue, metabolic alterations, and early cardiovascular complications. Both LMNA-linked lipodystrophies are characterized by the accumulation of the lamin A precursor prelamin A. The pathological mechanism by which prelamin A accumulation induces the lipodystrophy associated phenotypes remains unclear. Since the affected tissues in these disorders are of mesenchymal origin, we…
Factores de risco e protecção para os adolescentes em situação de vulnerabilidade ante o consumo de substâncias adictivas em Angola
2013
Embora se saiba que são numerosos e graves os efeitos do consumo tanto de bebidas alcoólicas como o de tabaco sobre a vida dos jovens, em Angola existe uma grande escassez de estudos que abordem esta temática. Por este motivo, são vários os objetivos deste trabalho: (1) Analisar o consumo de substâncias aditivas nos adolescentes angolanos; (2) Analisar as relações entre a auto-estima, inteligência emocional e apoio social com a resiliência dos adolescentes; (3) Analisar a predição da percepção do bem-estar subjetivo dos adolescentes; (4) Analisar a predição das atitudes ante o consumo de substâncias aditivas. A amostra, por conveniência, esteve constituída por 2739 adolescentes com idades c…
La gestió dels recursos humans
2019
El document forma part dels materials docents programats mitjançant l'ajut del Servei de Política Lingüística de la Universitat de València.: Es tracta de descriure la funció del departament dels recursos humans a nivell general i arribant a l'Oficina de Farmàcia. Descripció detallada de retribucions i elaboració de nòmines i revisió dels principals capítols del conveni col·lectiu