Search results for "reduction"
showing 10 items of 2058 documents
Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways.
1999
The aim of this study was to re-examine the human hepatic metabolism of diclofenac, with special focus on the generation of minor hydroxylated metabolites implicated in the idiosyncratic hepatotoxicity of the drug. Different experimental approaches were used: human hepatocytes, human microsomes, and engineered cells expressing single human CYP (cytochromes P450). Human hepatocytes formed 3'-hydroxy-, 4'-hydroxy-, 5-hydroxy- 4',5-dihydroxy-, and N,5-dihydroxydiclofenac, as well as several lactams. Formation of 4'- and 5-hydroxydiclofenac by human liver microsomes followed a Michaelis-Menten kinetics (Km 9 +/- 1 microM; Vmax 432 +/- 15 pmol/min/mg and Km 43 +/- 5 microM; and Vmax 15.4 +/- 0.6…
Influence of substrate oxidation on the reward system, no role of dietary fibre.
2011
International audience; It has been suggested that a high intake of dietary fibre helps regulate energy intake and satiety. The present study aimed to examine whether dietary fibre influenced the liking and wanting components of the food reward system, the metabolic state or subsequent intake. Five sessions involving 32 normal-weight subjects (16 men and 16 women, 30.6 ± 7.6 year) were held. The sessions differed in the composition of the bread eaten during breakfasts (dietary fibre content varied from 2.4 to 12.8 g/100 g). Several factors such as the palatability, weight, volume, energy content and macronutrient composition of the breakfasts were adjusted. Energy expenditure, the respirato…
Time multiplexing super-resolved imaging without a priori knowledge of the spatial distribution of the encoding structured illumination
2021
Time multiplexing is a super-resolution technique that sacrifices time to overcome the resolution reduction obtained because of diffraction. There are many super resolution methods based on time multiplexing, but all of them require a priori knowledge of the time changing encoding mask, which is projected on the object and used to encode and decode the high-resolution information. In this paper, we present a time multiplexing technique that does not require the a priori knowledge on the projected encoding mask. First, the theoretical concept of the technique is demonstrated; then, numerical simulations and experimental results are presented.
Towards automated diffraction tomography. Part II--Cell parameter determination.
2008
Automated diffraction tomography (ADT) allows the collection of three-dimensional (3d) diffraction data sets from crystals down to a size of only few nanometres. Imaging is done in STEM mode, and diffraction data are collected with quasi-parallel beam nanoelectron diffraction (NED). Here, we present a set of developed processing steps necessary for automatic unit-cell parameter determination from the collected 3d diffraction data. Cell parameter determination is done via extraction of peak positions from a recorded data set (called the data reduction path) followed by subsequent cluster analysis of difference vectors. The procedure of lattice parameter determination is presented in detail f…
Experimental Study Regarding PA and PE Sheets on Single Point Incremental Forming Process
2021
The present paper aims to present an experimental study on the behaviour of PA and PE sheets during the single point incremental forming. Due to the fact that the purpose of this research is to study the behaviour of PA and PE sheets during the single point incremental process both in terms of process forces and in terms of major and minor strain and thickness reduction, a Kuka Kr210 robot was chosen as an alternative to using a universal milling machine. The specimens were made of 3 mm PA and PE sheets. The size of the sheets was 250 mm x 250 mm. The forces measured on the three directions of the coordinate axes were compared. To measure the major strain, minor strain and thickness reducti…
Electro- and Photo-driven Reduction of CO 2 by a trans -(Cl)-[Os(diimine)(CO) 2 Cl 2 ] Precursor Catalyst: Influence of the Diimine Substituent and A…
2016
A series of [OsII(NN)(CO)2Cl2] complexes where NN is a 2,2′-bipyridine ligand substituted in the 4,4′ positions by H (C1), CH3 (C2), C(CH3)3 (C3), or C(O)OCH(CH3)2 (C4) has been studied as catalysts for the reduction of CO2. Electrocatalysis shows that the selectivity of the reaction can be switched toward the production of CO or HCOO− with an electron-donating (C2, C3) or -withdrawing (C4) substituent, respectively. The electrocatalytic process is a result of the formation of an Os0-bonded polymer, which was characterized by electrochemistry, UV/Visible and EPR spectroscopies. Photolysis of the complexes under CO2 in DMF+TEOA produces CO as a major product with a remarkably stable turnover…
Decision Support for Disaster Risk Management: Integrating Vulnerabilities into Early-Warning Systems
2014
International audience; Despite the potential of new technologies and the improvements of early-warning systems since the 2004 Tsunami, damage and harm caused by disasters do not stop to increase. There is a clear need for better integrating the fragmented landscape of researchers and practitioners working on different aspects of decision support for disaster risk reduction and response. To demonstrate and discuss the advantages of integrated systems, we will focus in this paper on vulnerabilities and early-warning systems. While vulnerabilities are mostly used to allocate risk management resources (preparedness), early-warning systems are designed to initiate the response phase. Indicator …
Universal Design of Information Sharing Tools for Disaster Risk Reduction
2019
International audience; Disaster information sharing tools are an important aspect of disaster resilience, and it is of utmost importance that these tools are accessible and usable for as many potential users as possible. In this paper, we evaluate the accessibility of a selection of tools for crowdsourcing disaster situation information. As our evaluation shows that the selected tools are not fully accessible, we provide recommendations for mitigation, as well as highlight the importance of further research in this area.
Epichristoffel Words and Minimization of Moore Automata
2014
This paper is focused on the connection between the combinatorics of words and minimization of automata. The three main ingredients are the epichristoffel words, Moore automata and a variant of Hopcroft's algorithm for their minimization. Epichristoffel words defined in [14] generalize some properties of circular sturmian words. Here we prove a factorization property and the existence of the reduction tree, that uniquely identifies the structure of the word. Furthermore, in the paper we investigate the problem of the minimization of Moore automata by defining a variant of Hopcroft's minimization algorithm. The use of this variant makes simpler the computation of the running time and consequ…
Unitary Groups Acting on Grassmannians Associated with a Quadratic Extension of Fields
2006
Let (V, H) be an anisotropic Hermitian space of finite dimension over the algebraic closure of a real closed field K. We determine the orbits of the group of isometries of (V, H) in the set of K-subspaces of V . Throughout the paper K denotes a real closed field and K its algebraic closure. Then it is well known (see, for example, [4, Chapter 2], [23]; see also [8]) that K = K(i) with i = √−1. Also we let (V,H) be an anisotropic Hermitian space (with respect to the involution underlying the quadratic field extension K/K) of finite dimension n over K. In this context we consider the natural action of the unitary group U = U(V,H) of isometries of (V,H) on the set Xd of all ddimensional K-subs…