Search results for "reduction"
showing 10 items of 2058 documents
Blue autofluorescence in protein aggregates “lighted on” by UV induced oxidation
2019
Oxidation of amino acid side chains in protein structure can be induced by UV irradiation leading to critical changes in molecular structure possibly modifying protein stability and bioactivity. Here we show, by using a combination of multiple spectroscopic techniques and Fluorescence Lifetime Imaging, that UV-light exposure induces irreversible oxidation processes in Ubiquitin structure. In particular, the growth of a new autofluorescence peak in the blue region is detected, that we attribute to tyrosine oxidation products. Blue autofluorescence intensity is found to progressively increase also during aggregation processes leading to the formation of aggregates of non-amyloid nature. Signi…
Algorithmic approaches to Siegel's fundamental domain
2017
Siegel determined a fundamental domain using the Minkowski reduction of quadratic forms. He gave all the details concerning this domain for genus 1. It is the determination of the Minkowski fundamental domain presented as the second condition and the maximal height condition, presented as the third condition, which prevents the exact determination of this domain for the general case. The latest results were obtained by Gottschling for the genus 2 in 1959. It has since remained unexplored and poorly understood, in particular the different regions of Minkowski reduction. In order to identify Siegel's fundamental domain for genus 3, we present some results concerning the third condition of thi…
Synthesis and gas chromatographic-mass spectrometric analysis of reduced compounds derived from 6 alpha- and 6 beta-hydroxy-11-deoxycorticosterone.
1989
Abstract A series of thirty two 6-hydroxylated steroids were synthesized by selective reduction of the 4–5 double bond, the 3-oxo group, and/or the 20-oxo group of 6α- and 6β-hydroxyDOC. The different reactions leading to the production of specific isomers are discussed. The gas chromatographic and spectrometric characteristics of the methoxime-trimethylsilyl (MO-TMS) or trimethylsilyl (TMS) derivatives of the isomers obtained are given. The gas chromatographic separation of the syn- and anti -isomers of the methoxime in position 3 was found to be characteristic of the configuration of the hydroxyl in position 6. The difference between methylene unit values of syn- and anti- isomers is much…
Inhibition of Granulocyte Function by Prednisolone and Non-Steroid Anti-Inflammatory Drugs. Quantitative Evaluation with NBT Test and its Correlation…
1980
The effect of prednisolone and non-steroid anti-inflammatory drugs on PMNL (polymorphonuclear leucocytes) oxidative metabolism was quantified with a newly standardized NBT test, and it was investigated whether these effects correlate with phagocytosing capacity of PMNL. Prednisolone inhibits NBT reduction in dose dependency already at concentrations, which do not interfere with phagocytosis. Thus prednisolone dissociates phagocytosis and phagocytosis-associated oxidative metabolism. High doses of prednisolone also inhibit phagocytosis. These effects of prednisolone are still demonstrable when PMNL are washed after pre-incubation with the drug. The non-steroid anti-inflammatory drugs (indome…
EUROASPIRE IV: A European Society of Cardiology survey on the lifestyle, risk factor and therapeutic management of coronary patients from 24 European…
2016
AIMS: To determine whether the Joint European Societies guidelines on cardiovascular prevention are being followed in everyday clinical practice of secondary prevention and to describe the lifestyle, risk factor and therapeutic management of coronary patients across Europe. METHODS AND RESULTS: EUROASPIRE IV was a cross-sectional study undertaken at 78 centres from 24 European countries. Patients <80 years with coronary disease who had coronary artery bypass graft, percutaneous coronary intervention or an acute coronary syndrome were identified from hospital records and interviewed and examined ≥ 6 months later. A total of 16,426 medical records were reviewed and 7998 patients (24.4% female…
Nonlinear PCA for Spatio-Temporal Analysis of Earth Observation Data
2020
Remote sensing observations, products, and simulations are fundamental sources of information to monitor our planet and its climate variability. Uncovering the main modes of spatial and temporal variability in Earth data is essential to analyze and understand the underlying physical dynamics and processes driving the Earth System. Dimensionality reduction methods can work with spatio-temporal data sets and decompose the information efficiently. Principal component analysis (PCA), also known as empirical orthogonal functions (EOFs) in geophysics, has been traditionally used to analyze climatic data. However, when nonlinear feature relations are present, PCA/EOF fails. In this article, we pro…
Seismic behavior of exterior RC beam-column joints without code-specified ties in the joint core
2021
Abstract Beam-column joint design for reinforced concrete (RC) buildings is a critical issue for modern earthquake engineering, because for these structural elements, the current codes provide several geometrical constraints and reinforcement provisions, which may be very complex to implement during the construction phase. To investigate how a construction error might influence the joint behavior, two identical full-scale exterior beam-column joints specimens are built, according to Italian Building Code specifications for the high ductility class, but without the required horizontal ties inside the joint panel. This construction error could be plausible because, according to the design dra…
‘Back to the Future’—Oak wood-pasture for wildfire prevention in the Mediterranean
2021
In the summer of 2021, enormous wildfires in the Mediterranean eliminated huge areas of mainly coniferous forest, destroyed adjacent settlements and claimed the lives of many people. The fires indicate effects of climate change and expose consequences of rural demographic changes, deficits in regional and touristic development planning and shortcomings in forest policy. This forum article highlights the dimensions of the problem, calls for a paradigm shift and shows solutions. Land abandonment, woody plant encroachment and non-reflective afforestation are leading to increasing amounts of combustible biomass. To prevent disastrous fires in future, fundamental changes in tree species composit…
From political controversy to a technical problem? Fifteen years of opioid substitution treatment in Finland
2013
Abstract Background The aim of the article is to analyze changes in opioid substitution treatments (OST) in Finland. OST spread in Finland in the late 1990s and early 2000s (Phase 1). Since then, OST has become an integrated part of Finnish drug policy and is provided in various substance abuse treatment units as well as in municipal health centers (Phase 2). Methods The paper analyses the policy around the implementation of opioid substitution treatment in Finland, focusing on identifying the key factors and the relations between them that have contributed to the implementation of OST in Finland. Results OST has become accepted in Finland during the past ten years as a crucial element of a…
After the Millennium Development Goals. Remarks on the ethical assessment of global poverty reduction success
2018
The Millennium Development Goals were effective from 2000 to 2015. Statistics show that most of the goals were met, and particularly success in the goal of reducing extreme poverty (MDG1) gained wide recognition. Despite the strong ethical language related to poverty reduction, there has been little analysis of the ethical significance of the MDG achievements. Since statistical and ethical definitions and representations of poverty never completely overlap, conclusions concerning ethical progress are not directly available from the statistics. This article shows how this ethical significance can be analysed and what kinds of controversies and uncertainties relate to the issue. As part of th…