Search results for "regeneration"
showing 10 items of 889 documents
Direct Reprogramming of Somatic Cells into Induced Neuronal Cells: Where We Are and Where We Want to Go
2014
Direct reprogramming of somatic cells has emerged as a novel strategy to generate neurons, including those of human origin. The method provides enormous potential for studying the mechanisms directing neuronal differentiation, the modeling of neurodegenerative diseases, and the development of potential novel approaches for brain repair. In this chapter, we briefly trace the history of reprogramming, as well as the strategies employed to date for converting different types of somatic cells, including fibroblasts, hepatocytes, astrocytes, and pericytes into induced neuronal cells of different subtype identity. Reprogramming involves particular emphasis on transcriptional and posttranscription…
Urban regeneration of abandoned and contaminated industrial areas. Case study: Eternitten district in Aalborg (DK)
2020
The article describes the decontamination and regeneration process of the Eternitten district, an abandoned industrial complex for the production of cement and asbestos south of Aalborg, in a new multifunctional and sustainable neighbourhood. The designation of the district as an urban transformation area is part of a general regeneration of Aalborg whose industrial profile is gradually being replaced by a new profile more oriented towards culture and innovation. Eternittens Vidensby Village 21, from eternit factory to knowledge factory, is the vision – developed by Kjær & Richter for Søren Enggaard A/S – for an innovative use of the neighbourhood. The vision, which is inspired by the v…
Eternitten Village 21: the city of knowledge. From industrial contamination to social and cultural contamination
2020
The paper describes the decontamination and regeneration process of the Eternitten district, an abandoned industrial complex for the production of cement and asbestos south of Aalborg, in a new multifunctional and sustainable neighbourhood. The designation of the district as an urban transformation area is part of a general regeneration of Aalborg whose industrial profile is gradually being replaced by a new profile more oriented towards culture and innovation. Eternittens Vidensby Village 21, from eternit factory to knowledge factory, is the vision developed by Kjær & Richter for Søren Enggaard A/S for an innovative use of the neighbourhood. The vision, which is inspired by the village…
Trasformazione e riuso dei vuoti urbani: quattro casi studio
2016
Il saggio indaga su contesti urbani consolidati che contengono tracce appartenenti a preesistenze industriali oggi in disuso, ma che costituiscono originali trame urbane da reinterpretare, riqualificare e riutilizzare in alternativa alle nuove espansioni. Il progetto della trasformazione/cambiamento diviene una metodologia d’intervento che richiede approcci, sensibilità e strumenti adeguati, che vanno dal controllo urbanistico a quello architettonico, dalla verifica tecnologica e strutturale a quella sociale e fruitiva. Sono presentate alcune ipotesi progettuali che illustrano come la valorizzazione delle aree industriali possa contribuire alla rigenerazione urbana di interi quartieri o por…
De barrio-problema a barrio de moda: gentrificación comercial en Russa-fa, El “Soho” valenciano
2015
Russafa neighborhood in Valencia (Spain) has become the center of one of the most ambitious urban redevelopment plans implemented by the local council in recent years. This old neighborhood of merchants and artisans, that during the 80's and 90’s experienced a long period of degradation and neglect, is today the multicultural trendy district for tourists and citizens The aim of this paper is to show the gentrification process emerged in this neighborhood, and how from the abandonment that characterized it just a decade ago, it has undergone a fast process of festivalization and economic transformation with the arrival of the “creative classes”, that so far has caused few reactions, despite …
Regeneration of herbicide-tolerant black locust transgenic plants by SAAT
2003
A protocol based on SAAT (sonication-assisted Agrobacterium-mediated transformation) has been developed to obtain herbicide-resistant transgenic black locust (Robinia pseudoacacia L.) plants. Cotyledon explants were co-cultivated with Agrobacterium AGL1 strain carrying the pTAB16 plasmid (bar and gusA genes). The effects of bacterial concentration (OD550 of 0.3, 0.6, 0.8) and method of infection (sonication vs immersion) on bacterial delivery were determined by assaying cotyledons for transient beta-glucuronidase expression 3 days after infection. SAAT increases transient expression efficiency especially at an OD550 of 0.6. After determining bacterial concentration and infection method, oth…
Novel solutions for closed-loop Reverse Electrodialysis: thermodynamic characterisation and perspective analysis
2019
Abstract Closed-loop Reverse Electrodialysis is a novel technology to directly convert low-grade heat into electricity. It consists of a reverse electrodialysis (RED) unit where electricity is produced exploiting the salinity gradient between two salt-water solutions, coupled with a regeneration unit where waste-heat is used to treat the solutions exiting from the RED unit and restore their initial composition. One of the most important advantages of closed-loop systems compared to the open systems is the possibility to select ad-hoc salt solutions to achieve high efficiencies. Therefore, the properties of the salt solutions are essential to assess the performance of the energy generation a…
Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver
1998
Studies with tumor necrosis factor p55 receptor- and interleukin-6 (IL-6)-deficient mice have shown that IL-6 is required for hepatocyte proliferation and reconstitution of the liver mass after partial hepatectomy. The biological activities of IL-6 are potentiated when this cytokine binds soluble forms of its specific receptor subunit (sIL-6R) and the resulting complex interacts with the transmembrane signaling chain gp130. We show here that double transgenic mice expressing high levels of both human IL-6 and sIL-6R under the control of liver-specific promoters spontaneously develop nodules of hepatocellular hyperplasia around periportal spaces and present signs of sustained hepatocyte prol…
The compensatory regeneration of the operculum ofHydroides norvegica: Identification of the inhibiting substance
1973
In the polychete Hydroides norvegica there are two opercula with different degrees of organization: one is completely developed and functional, the other, present only in rudimentary outline. The latter only begins to develop when the functional operculum is removed. It was observed that in the whole body of the Hydroides, but particularly in the functional operculum, there is a substance which inhibits the development of the rudimental operculum. This substance was purified in order to determine its chemical nature. From preparation of opercular homogenates we chemically separated numerous fractions, each of which was tested for inhibitory activity and chemical and physical properties. The…
New insights into the cellular makeup and progenitor potential of palatal connective tissues
2017
The present study investigated the regenerative potential of connective tissues harvested from two palatal areas widely used as donor sites for muco-gingival surgical approaches. Connective tissue grafts (CTGs) were obtained by de-epithelialisation of a free gingival graft (deCTG) and by a split flap approach from a previous donor site (reCTG). Two types of mesenchymal stem cell (MSCs) were isolated and were named de-epithelialised MSCs (deMSCs) and re-entry MSCs (reMSCs). The cells were characterised and cellular functionality was investigated. CTGs were evaluated using immunohistochemical and ultrastructural approaches. No significant differences were observed regarding the frequency of c…