Search results for "regeneration"
showing 10 items of 889 documents
Il Paradigma della Città Fluida
2013
Nella recente crisi globale i poderosi flussi di capitali finanziari, sociali e relazionali che hanno alimentato la riqualificazione urbana nel corso degli ultimi quindici anni non sono più disponibili ad essere intercettati in maniera indiscriminata così come è stato possibile fino a qualche anno fa. Nell'era della crisi strutturale le città più dinamiche non sono più quelle in grado di attrarre progetti urbani iconici ed investitori spinti dal mercato immobiliare o dalla redditività delle attività ricreative, ma quelle città che, a partire dalle loro profonde e diversificate risorse culturali, saranno capaci di attuare una vera e propria “metamorfosi” per usarle come base per la creazione…
Invertebrate Models in Innate Immunity and Tissue Remodeling Research
2022
The aim of this Special Issue is to highlight the close functional and highly conserved link between innate immunity, homeostasis maintenance, inflammation, tissue remodeling and regeneration [...]
ARCHITETTURA, CUSTODE DELLA NATURA : il progetto di suolo nella trasformazione delle autostrade urbane, 1962-2018
2023
Un inarrestabile cambiamento nel paradigma con cui l’uomo concepisce la propria specie rispetto ai suoi modi di costruire è alla base dell’attrattiva per l’incorporazione del vegetale nell’Architettura. Lo statuto euristico di maggiore capacità di tale nuovo corso è la sostituzione progressiva dell’Ambiente alla Natura fra i motori della Composizione. Su questo sfondo, l’articolo indaga l’ibridazione del vegetale e del costruito nella trasformazione contemporanea delle grandi autostrade urbane, attraverso un approccio diacronico e comparativo, in riferimento a una ricerca internazionale di cui estende l’ipotesi principale. A tal fine, ricostruisce il telaio ermeneutico di riferimento discut…
La valutazione ambientale delle strategie urbane di sviluppo: nuovi modelli per l'integrazione ambientale delle scelte in ambito urbanistico
2017
La valutazione ambientale strategica è, prima di essere codificata nelle forme della VAS, una possibile declinazione della pianificazione strategica che nelle tematiche ambientali della sostenibilità e, potenzialmente, nei paradigmi dell’ecological urbanism o del re-cycle un nuovo modo di lavorare al progetto urbanistico. Il paper descrive le attività svolte in tal senso dal Dipartimento Regionale dell’Urbanistica (DRU) della Regione Siciliana con la collaborazione scientifica di chi scrive, al fine di ripensare la VAS come un modello di progettazione della trasformazione urbana anziché come un accessorio a posteriori del Piano. L’emanazione della Direttiva 1/2015 DRU/VAS e le conseguenti a…
Non-oxidative dehydroaromatization of methane:an effective reaction regeneration cyclic operation for catalyst life extension
2015
[EN] Non-oxidative methane aromatization is an attractive direct route for producing higher hydrocarbons. It is highly selective to benzene despite the low conversion due to thermodynamic limitations, and Mo/H-ZSM-5, the first catalyst proposed for this reaction, is still considered as one of the most adequate. The major problem of this process is the severe catalyst deactivation due to the rapid build-up of carbonaceous deposits on the catalysts. Here we present an effective regeneration procedure that extends the life of Mo/zeolite based catalysts by combining reaction periods of 1.5 h with 0.5 h regeneration steps in a continuous cyclic mode and methane activation after each regeneration…
Reconstruction of full thickness scalp defects after tumour excision in elderly patients: our experience with Integra dermal regeneration template.
2010
Summary Background Scalp reconstruction after wide tumor excision is particularly challenging. Free tissue transfers, local flaps, or skin grafts can be used but present some disadvantages especially with old patients with local advanced cancers, systemic diseases and in patients with a prior history of recurring scalp skin cancers in which the risk of burying a recurring tumor with a flap is likely. The Authors expose their early experience with Integra ® dermal regeneration template for scalp reconstruction after scalp tumor excision. Methods Eight patients with primary or secondary scalp tumor underwent a first surgical procedure under local anaesthesia for tumor removal and Integra ® po…
Innate immunity repairs gut lining
2015
It emerges that innate immune cells called group 3 innate lymphoid cells signal directly to intestinal stem cells to promote the replacement of damaged epithelial cells lining the gut. See Letter p.560 The cellular signals supporting normal epithelial intestine maintenance through regulation of intestinal stem cell (ISC) activity are well characterized, but the signals involved in the regulation of the ISC compartment after damage are still unclear. Alan Hanash and colleagues have found that innate lymphoid cells produce interleukin-22 (IL-22) after injury to increase the growth of mouse intestinal organoids. They further show that recombinant IL-22 promotes ISC expansion in both human and …
Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool.
2015
Tissue homeostasis is achieved through a balance of cell production (growth) and elimination (regression). In contrast to tissue growth, the cells and molecular signals required for tissue regression remain unknown. To investigate physiological tissue regression, we use the mouse hair follicle, which cycles stereotypically between phases of growth and regression while maintaining a pool of stem cells to perpetuate tissue regeneration. Here we show by intravital microscopy in live mice that the regression phase eliminates the majority of the epithelial cells by two distinct mechanisms: terminal differentiation of suprabasal cells and a spatial gradient of apoptosis of basal cells. Furthermor…
Spatial effects of urban public policies on housing values
2009
International audience; Problems of spatial segregation have often stressed on the social status and social capital of a neighbourhood as main driving forces behind housing price formation. In this paper, it is assumed that spatial effects are additional variables worth considering since the impact of urban policies such as social housing policies and urban regeneration policies may permeate outside the areas where they are implemented. Our case study is of the urban area of Dijon (France), where these two types of urban policies have been implemented in the last three decades. Spatial effects are introduced in the hedonic model and a spatial error model is estimated, revealing a positive a…
Development of an lbuprofen-Releasing Biodegradable PLA/PGA Electrospun Scaffold for Tissue Regeneration
2009
Our aim was to develop a biodegradable fibrous dressing to act as a tissue guide for in situ wound repair while releasing Ibuprofen to reduce inflammation in wounds and reduce pain for patients on dressing changes. Dissolving the acid form of Ibuprofen (from 1% to 10% by weight) in the same solvent as 75% polylactide, 25% polyglycolide (PLGA) polymers gave uniformly loaded electrospun fibers which gave rapid release of drug within the first 8 h and then slower release over several days. Scaffolds with 10% Ibuprofen degraded within 6 days. The Ibuprofen released from these scaffolds significantly reduced the response of fibroblasts to major pro-inflammatory stimulators. Fibroblast attachment…