Search results for "regeneration"
showing 10 items of 889 documents
Il ruolo della periferia nella costruzione della città moderna
2023
The essay critically traces some exempla of public residential housing that have characterised the development of the urban periphery of 20th century Italian cities. There are many experiences that describe the close union that existed throughout the last century between the suburbs and the construction of new public housing in our country. In this regard, three different historical thresholds that mark as many significant moments in the urban history of Italian cities are identified. The different periods correspond with the promulgation of likewise laws. The first one in chronological order was the Luzzati Law, which tried to respond to the industrial city needs for new housing through th…
Manipolazione tipologica
2021
The team, since the early stages of the project, has worked with the will to seize, in collaboration and multidisciplinary dialogue, an opportunity for cultural and scientific growth to achieve shared solutions. The regeneration of the area subject of this study has assumed four elementary actions as operational tools declined to the urban, architectural and technological scale: include, subtract, add and connect. In Tor Bella Monaca, the lack of sense of urbanity is the real cause of environmental discomfort. The size, the layout and the position of the large residential units deprive the inhabitants of a sense of belonging to the city that has been reformulated by reorganizing the greener…
The Good Practice Framework for European Sustainable Urbanisation through port city Regeneration. An operative guide
2020
The ENSURE research reveals that port cities are relevant in sustainable urban regeneration. Taking into account the sensitivity of urban and port contexts, and the solutions adopted across European port cities, this Guide delivers a set of key policies in order to plan and manage the regeneration process, and describes how to apply a suitable model for regeneration in port cities.
Sustainable regeneration of port cities
2020
Despite overall growth in the maritime sector, many European port cities are challenged by the migration of port-related activities from inner-city areas to other locations. The relocation of these economic activities results in the emergence of brownfield sites in strategic urban locations. Reusing these sites in a sustainable manner can contribute to preventing new land take and the regeneration of port cities. The city of Brest (France) is a good example of a port city that rejuvenated its inner-city area in a sustainable way.
Comparative study assessing effects of sonic hedgehog and VEGF in a human co-culture model for bone vascularisation strategies.
2011
The morphogen sonic hedgehog (Shh) seems to mediate adult repair processes in bone regeneration and vascularisation. In this study we investigated the effects of Shh on co-cultures consisting of human primary osteoblasts and outgrowth endothelial cells in terms of angiogenic activation and vessel maturation in comparison to the treatment with the commonly used proangiogenic factor, VEGF. Both, stimulation with VEGF or Shh, leads to an increase in the formation of microvessel-like structures compared to untreated controls. In contrast to VEGF, proangiogenic effects by Shh could already be observed after 24 h of treatment. Nevertheless, after 14 days the angiogenic activity of OEC was compara…
Sonic hedgehog promotes angiogenesis and osteogenesis in a coculture system consisting of primary osteoblasts and outgrowth endothelial cells.
2009
A number of previous studies documented the angiogenic potential of outgrowth endothelial cells in vitro and in vivo and provided evidence that therapeutic success could depend on coculture or coimplantation strategies. Thus, deeper insight into the molecular mechanisms underlying this pro-angiogenic effect of cocultures might provide new translational options for tissue engineering and regenerative medicine. One promising signaling pathway in bone repair involved in neoangiogenesis and bone formation is the sonic hedgehog (Shh) pathway. In this article, we focus on the effect of Shh on the formation of microvessel-like structures and osteoblastic differentiation in cocultures of primary os…
Priming with a combination of proangiogenic growth factors improves wound healing in normoglycemic mice
2011
Growth factors and/or angiogenic factors are supposed to improve wound healing. The aim of our study was to evaluate the effects of subcutaneous pretreatment with combinatory proangiogenic factors on wound closure, mechan - ical properties, vessel density and morphology. Twenty-eight Balb/c mice were divided equally into two groups. A mixture of VEGF (35.0 µg), bFGF (2.5 µg) and P dGF (3.5 µg) was administered subcutaneously 3, 5 and 7 days to 14 mice before full thickness skin punch biopsy wounding, whereas 14 control animals received three injections of 0.2 ml saline solution. Wound sizes were assessed daily and the repaired tissues were harvested 7 days after complete wound closure. Comp…
Modification of xenogenic bone substitute materials - effects on the early healing cascadein vitro
2013
Introduction Initial platelet activation with subsequent cytokine release at the defect site plays a crucial role in tissue integration. The aim of this study was to evaluate the influence of topographic and biomimetic collagen modifications of a xenogenic bone substitute material (BSM) on in vitro platelet activation and cytokine release. Material and Methods Three types of xenogenic BSM were used. Two BSM with different levels of granularity (large granule BSM [XBSM/L], small granule BSM [XBSM/S]) and a BSM with collagen (XBSM/C). All three samples were incubated with platelet concentrate of four healthy volunteers at room temperature for 15 min. For all groups, highly thrombogenic collag…
From Waterfront Regeneration to Fluid City Planning
2013
In current global crisis the strong flows of financial, social and relational capitals that powered urban regeneration over the last fifteen years are no longer available to be tapped in an indiscriminate manner as was the case until just a few years ago. The most dynamic cities in the future will no longer be those that are able to attract urban projects and investors driven by the real estate market or leisure-based development, but the cities that have deep and different cultural resources and that are able to use them as the basis for creating new urban cultures and for generating new economic values. Revitalising waterfront is no longer easy opportunity for long-term investments or for…
Chronic Adult Hydrocephalus
1974
Knowledge of Wallerian degeneration began in 1852 and, following experimental research on degeneration and regeneration of interrupted nerves, surgeons realized that reinnervation of end organs depended on growth of axons through the interrupted area of nerve. Therefore surgeons tried to reanastomose the stumps. Failures of reinnervation could not be blamed on lack of axoplasma metabolism and flow from cell body to suture line because the clinical observation of amputation neuromas and their constant recurrence demonstrated the unfailing delivery of axoplasma by the nerve cell body; at times to the deep concern of the surgeon, and the constant pain of the patient. The electron microscope sh…