Search results for "regression"
showing 10 items of 2619 documents
Exploring Neighborhood Influences on Small-Area Variations in Intimate Partner Violence Risk: A Bayesian Random-Effects Modeling Approach
2014
This paper uses spatial data of cases of intimate partner violence against women (IPVAW) to examine neighborhood-level influences on small-area variations in IPVAW risk in a police district of the city of Valencia (Spain). To analyze area variations in IPVAW risk and its association with neighborhood-level explanatory variables we use a Bayesian spatial random-effects modeling approach, as well as disease mapping methods to represent risk probabilities in each area. Analyses show that IPVAW cases are more likely in areas of high immigrant concentration, high public disorder and crime, and high physical disorder. Results also show a spatial component indicating remaining variability attribut…
Application of the Wood model to lactation curves of Comisana sheep
1997
Abstract Ninety-two ewes of the Comisana breed were used in a study to verify the forecasting capacity of the mathematical model proposed by Wood for fitting sheep data, and to evaluate the effect of the environmental factors affecting the parameters of the lactation curve. The Wood model underestimated the total lactation milk production with an error margin of 12.2 ± 7.8 kg of milk corresponding to 10.9 ± 6.6%. There was a strong influence of order of lambing × lambing season interaction on the lactation parameters. The curves for the winter lambing ewes demonstrated a higher peak production than autumn lambing ewes (1728.4 vs. 1082.6 g, P ≤ 0.05 for the second lambing ewes and 1772.8 vs.…
Mindfulness, inattention and performance in a driving simulator
2015
The following study will explore the link between mindfulness, driver inattention and a number of driving performance variables that were tested using the SIMUVEG driving simulator. 67 subjects between the ages of 19 and 27 completed the mindful attention awareness scale, attention-related driving errors scale and attention-related cognitive errors scale questionnaires, and were evaluated in two driving performance measures: time to line-crossing and mean speed. The results did not show a correlation between driving performance and mindfulness measures; they did show low but significant correlations with driver inattention measures. A regression analysis suggested that the specific measure …
Interaction risk with proton pump inhibitors in general practice: significant disagreement between different drug-related information sources.
2006
Aims To compare information on drug–drug interactions (DDIs) reported on two standard drug-related information sources (Summary of Product Characteristics and Drugdex system by Micromedex), by assessing the prevalence and predictors of potential DDI with proton pump inhibitors (PPIs) in general practice. Methods From the ‘Caserta-1’ Local Health-Service database, 156 general practitioners (GPs) were recruited. From more than 180 000 individuals registered on their lists, we selected patients receiving co-prescription of PPI and medications at interaction risk, according to the Italian Summary of Product Characteristics (SPC) of PPI and Drugdex information, during the year 2003. Thereafter, …
Influence of concomitant medications on the total clearance and the risk for supra-therapeutic plasma concentrations of Citalopram. A population-base…
2014
Introduction: The main objective of this study was to investigate the influence of the use of multiple medications and other risk factors on citalopram plasma concentrations. Methods: A retrospective cohort study with a naturalistic population of 957 patients for whom routine therapeutic drug monitoring (TDM) of citalopram had been requested between 2006 and 2013 was conducted. Results: Concomitant drugs inhibiting at least 2 different CYP subtypes involved in the metabolism of citalopram decreased statistically significantly the total clearance (Clt). Compared to younger patients over 64-year-old patients had on average a 4.5 times higher risk rate of supra-therapeutic plasma concentration…
[Drugs use in pregnancy in the Valencia Region and the risk of congenital anomalies].
2017
Background Despite the potential risks of drug use during pregnancy, consumption has increased in recent decades. Objective To identify the risk of congenital anomalies (CA) associated with the use of drugs in primary care in pregnant women resident in the Valencia Region. Methods A case-control study, considering a case as a less than one year old live birth in 2009–2010, diagnosed with a CA and resident in the Valencia Region, obtained from the CA population-based registry. Controls were selected from the Metabolic Disease Registry, and the drugs prescribed and dispensed from the Integral Management of Pharmaceutical Services. Crude odds ratio (OR) was calculated with its 95% confidence i…
Potential of biopartitioning micellar chromatography as an in vitro technique for predicting drug penetration across the blood–brain barrier
2004
The blood-brain barrier (BBB) is considered to be the main barrier to drug transport into the central nervous system (CNS). The BBB restricts the passive diffusion of many drugs from blood to brain. The ease with which any particular drug diffuses across the BBB is determined largely by the molecular features of drugs, and it is therefore possible to predict the BBB permeability of a drug from its molecular structure. Biopartitioning micellar chromatography (BMC), a mode of micellar liquid chromatography that uses micellar mobile phases of Brij35 in adequate experimental conditions, can be useful in mimicking the drug partitioning process into biological systems. Retention in BMC depends on…
Trends in psychotropic drug prescribing in Norwegian nursing homes from 1997 to 2009: a comparison of six cohorts
2012
Background Psychotropic drugs are extensively prescribed for the treatment of neuropsychiatric symptoms, despite modest efficacy and severe side effects. Aims We examined trends in psychotropic drug prescribing in Norwegian nursing homes from 1997 to 2009, in order to gain insight in practice development. Methods The study is a secondary data analysis of six cross-sectional nursing home studies conducted between 1997 and 2009. Patients aged >65 years were included. We compared the prevalence of psychotropic drugs (antipsychotics, anxiolytics, hypnotics, and antidepressants). Associations between prescription of psychotropics, and patients' age, gender, type of ward, and year of data collect…
Water erosion prediction by stochastic and empirical models in the Mediterranean: A case study in Northern Sicily (Italy)
2012
The present thesis aimed to explore the methodological advantages as well as limitations in applying different modelling approaches to predict water soil erosion in Mediterranean environments. The research was accomplished in the central northern part of Sicily (Italy), considering this region to be representative of Mediterranean environmental conditions. In this region soil degradation problems, due to water erosion are becoming more and more serious. Consequently, defining models being able to predict erosion susceptibility and to discriminate environmental factors causing erosion is important to protect soil resources. The prediction of the spatial distribution of soil erosion processes…
Directly Observed Physical Activity among 3-Year-Olds in Finnish Childcare
2014
The main purpose of the study was to determine 3-year-olds’ physical activity levels and how these vary across season, gender, time of day, location, and the physical and social environment in childcare settings in Finland. A modified version of the Observational System for Recording Physical Activity in Children-Preschool (OSRAC-P) was used to measure physical activity levels and contextual variables (e.g., group composition, prompts) of children attending childcare centres. In total, 81 children (42 boys and 39 girls) were observed in autumn and in winter. Three-level linear regression analyses were used to assess differences between the seasons in the association between the context vari…