Search results for "regulation"
showing 10 items of 4463 documents
Promoter architecture and transcriptional regulation of Abf1-dependent ribosomal protein genes inSaccharomyces cerevisiae
2016
In Saccharomyces cerevisiae, ribosomal protein gene (RPG) promoters display binding sites for either Rap1 or Abf1 transcription factors. Unlike Rap1-associated promoters, the small cohort of Abf1-dependent RPGs (Abf1-RPGs) has not been extensively investigated. We show that RPL3, RPL4B, RPP1A, RPS22B and RPS28A/B share a common promoter architecture, with an Abf1 site upstream of a conserved element matching the sequence recognized by Fhl1, a transcription factor which together with Ifh1 orchestrates Rap1-associated RPG regulation. Abf1 and Fhl1 promoter association was confirmed by ChIP and/or gel retardation assays. Mutational analysis revealed a more severe requirement of Abf1 than Fhl1 …
The mRNA degradation factor Xrn1 regulates transcription elongation in parallel to Ccr4
2019
Abstract Co-transcriptional imprinting of mRNA by Rpb4 and Rpb7 subunits of RNA polymerase II (RNAPII) and by the Ccr4–Not complex conditions its post-transcriptional fate. In turn, mRNA degradation factors like Xrn1 are able to influence RNAPII-dependent transcription, making a feedback loop that contributes to mRNA homeostasis. In this work, we have used repressible yeast GAL genes to perform accurate measurements of transcription and mRNA degradation in a set of mutants. This genetic analysis uncovered a link from mRNA decay to transcription elongation. We combined this experimental approach with computational multi-agent modelling and tested different possibilities of Xrn1 and Ccr4 acti…
I ‘‘diritti dell’interessato’’ nel Regolamento generale sulla protezione dei dati personali
2019
The essay analyzes the Regulation EU 2016/679 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data and it pursues the specific goal of providing a unitary reading of the so-called rights of the data subject, whose is proposed a framing as a set of powers, faculties and remedies intended to make up the content of the unitary right of the protection of personal data. The examination of these individual subjective prerogatives allows us to better define the extent and nature of the right of the protection of personal data, also in order to test the consistency of the discipline contained in the Regulation with the proclaimed …
Expectations and forward risk premium in the Spanish deregulated power market
2010
Abstract Deregulation in energy markets has entailed important changes in the way agents conduct business. Price risk arises as a result of fluctuations in the future price of electricity and agents assume long or short positions in the forward and spot markets to hedge their exposure to price risk. The presence of forward risk premium in prices is evidence of the fact that agents act in the market according to risk considerations. This work aims to analyse the information content of the difference between the forward and spot prices (the so-called forward premium) regarding the agents’ decisions. We find that the sign and magnitude of the ex post forward premium depend on the unexpected va…
Derivative Disclosure Practices in the Annual Financial Reporting of Large European Banks: A Cross-country Empirical Study
2018
The topic of this paper is derivative reporting in banking. The authors employ content analysis to conduct an empirical study on a sample of large European banks. The research aims to assess the qualitative and quantitative profiles of derivative disclosure in banking institutions. The paper provides evidences that banks differ in their derivative reporting, even though they are subject to similar regulatory requirements and accounting standards. The paper also shows that there is room to improve various aspects of derivatives disclosure in banking.
Evidence, and replication thereof, that molecular-genetic and environmental risks for psychosis impact through an affective pathway
2022
AbstractBackgroundThere is evidence that environmental and genetic risk factors for schizophrenia spectrum disorders are transdiagnostic and mediated in part through a generic pathway of affective dysregulation.MethodsWe analysed to what degree the impact of schizophrenia polygenic risk (PRS-SZ) and childhood adversity (CA) on psychosis outcomes was contingent on co-presence of affective dysregulation, defined as significant depressive symptoms, in (i) NEMESIS-2 (n = 6646), a representative general population sample, interviewed four times over nine years and (ii) EUGEI (n = 4068) a sample of patients with schizophrenia spectrum disorder, the siblings of these patients and controls.ResultsT…
La Confederación fallida. Administración y usuarios en la cuenca del Turia (1928-1936)
2012
[EN] Between 1928 and 1936 the projects of river regulation in the Turia basin caused important conflicts. A private company, REVA, obtained a legal concession to build several reservoirs and hydropower stations. The traditional users rejected this initiative and promoted the creation of a basin authority, the Confederación Hidrográfica del Turia, in order to stop the private action, and to control the management of the river regulation. This article describes the different stages of this conflict, analyzing the position of all the involved agents, in order to improve our knowledge on a key period for the implementation of the Spanish basin authorities.
Rotavirus stimulates release of serotonin (5-HT) from human enterochromaffin cells and activates brain structures involved in nausea and vomiting
2011
Rotavirus (RV) is the major cause of severe gastroenteritis in young children. A virus-encoded enterotoxin, NSP4 is proposed to play a major role in causing RV diarrhoea but how RV can induce emesis, a hallmark of the illness, remains unresolved. In this study we have addressed the hypothesis that RV-induced secretion of serotonin (5-hydroxytryptamine, 5-HT) by enterochromaffin (EC) cells plays a key role in the emetic reflex during RV infection resulting in activation of vagal afferent nerves connected to nucleus of the solitary tract (NTS) and area postrema in the brain stem, structures associated with nausea and vomiting. Our experiments revealed that RV can infect and replicate in human…
Uncertainty at Work How to Regulate it through Leadership in order to improve the Quality of Work Life?
2022
This thesis manuscript focuses on factors able to regulate the uncertainty of people at work. Due to the constant evolution of the organizational world, uncertainty is increasingly becoming a factor with which to combine in different contexts about work. This factor constitutes a risk for individuals due to its aversive nature. In this perspective we have been interested, on the one hand, about theories concerning the concept of uncertainty. This allowed us to better understand and delimit the concept. On the other hand, we looked for ways to regulate uncertainty through the concept of leadership. This led us to consider this regulation as being either potentially possible through a directi…
The telomeric Cdc13-Stn1-Ten1 complex regulates RNA polymerase II transcription
2019
Advance article.