Search results for "regulation"

HOW TO IMPROVE METACOGNITION IN PRIMARY SCHOOL

2014

Educational and psychological research in the past decade has found that metacognitive capacity starts earlier than was initially realized; is more amenable to educational intervention than was previously thought; can be taught to a wide range of learners; and is both inherently contextual and a unique capacity that is distinguishable from intelligence, cognitive processes and motivation. In this paper we will see how metacognition can be improved in primary school pupils when teachers use instructional strategies that encourage meaningful learning, stimulate metacognitive reflection and provide continuous feedback. The purpose of this article is to explore the notion of metacognition with …

Self-regulation of learning: the potential technologies impact of the metacognitive approach

2012

Self-regulation researchers theorize that self-regulation does not occur when learners display personal initiative, perseverance, and adaptive skill in pursuing learning. At its core, self-regulation involves self-motivation as well as metacognitive processes. Reflection on the process of learning is believed to be an essential ingredient in the development of expert teachers. By employing reflective thinking skills to evaluate the results of one’s own learning efforts, awareness of effective learning strategies can be increased and ways to use these strategies in other learning situations can be understood. In this paper, we describe how expert teachers use the knowledge they have gained o…

Statistical Validation of a Comprehensive Gene/miRNA Expression Profile Dataset for miRNA:mRNA Interaction Analysis

2014

Functions of the translation factor eIF5A in cellular metabolism and transcriptional control

2023

El factor de inicio de traducción de eucariotas 5A (eIF5A) es una proteína esencial y conservada con funciones en las tres fases de la traducción. eIF5A está codificado por dos genes parálogos, TIF51A/TIF51B y EIF5A1/EIF5A2 en levadura y humanos respectivamente. eIF5A es la única proteína que contiene hipusina, una modificación esencial para su actividad, y se une a los ribosomas para facilitar la traducción de motivos con prolinas consecutivas o combinaciones de prolina con glicina y aminoácidos cargados. eIF5A participa en otras funciones y procesos como exporte de mRNAs nucleares, proliferación y apoptosis. Su asociación con enfermades como el cáncer es de interés. En esta tesis se han u…

Behavior regulations and motives to participate in physical activity of Finnish team sports athletes

2014

The study examined the motivation to participate and behavior regulation in team sports among Finnish athletes. It explored differences across gender and among various team sport types. One hundred and seventy five girls and 142 boys (aged 12 to 24 years old) participated in the study. Motives to participate were measured on the Physical Activity and Leisure Motivation Scale (PALMS, Morris & Rogers, 2004), while behavior regulations were measured on the Behavior Regulation in Sport Questionnaire (BRSQ, Lonsdale, Hodge & Rose, 2008). Others' expectation was excluded from calculations due to low reliability. Participants scored higher on mastery, enjoyment and physical condition in PALMS scal…

Participation in dance training in Finland : a study of motives and behavior regulation

2014

According to the self-determination theory (Deci & Ryan, 1985; 2000), motivation mediates the relationship between physical activity participation and well-being. In environments such as classical ballet that are highly controlling and competitive, intrinsic motives towards training and self-determined forms of behavior regulation are especially important. Therefore, the purpose of the current study was to examine the various participation motives and behavior regulations of dance students. A secondary aim was to investigate group differences across age, competitive level and dance form. Altogether 103 dance students from three schools across Southern Finland completed the Physical Activity…

ShRNA-mediated knock-down of CXCL8 inhibits tumor growth in colorectal liver metastasis.

2018

CXCL8 belongs to proinflammatory chemokines that are predominantly involved in neutrophil chemotaxis and degranulation. Several studies have suggested that secretion of CXCL8 from cancer cells have a profound effect on tumor microenvironment. In this study, in continuation to our previous work of understanding the global picture of invasion related genes in colorectal liver metastases, we clearly show an up-regulation of CXCL8 expression in the tumor cells at the invasion front as compared to the tumor cells in the inner parts of the tumor. Furthermore, ShRNA mediated down-regulation of CXCL8 resulted in inhibition of cell proliferation, viability and invasion in vitro and a near complete g…

Anti-senescence and Anti-inflammatory Effects of the C-terminal Moiety of PTHrP Peptides in OA Osteoblasts.

2016

Osteoarthritis (OA) is characterized by degenerative changes in the whole joint leading to physical disability in the elderly population. This condition is associated with altered bone metabolism in subchondral areas suggesting that therapeutic strategies aimed at modifying bone cell metabolism may be of interest. We have investigated the effects of several parathyroid hormone-related protein (PTHrP)-derived peptides (1-37): (N-terminal), (107-111) and (107-139) (C-terminal) on senescence features induced by inflammatory stress in human OA osteoblasts. Incubation of these primary cells with interleukin(IL)-1β led to an increased expression of senescence markers senescence-associated-β-galac…

Myotonic dystrophy: candidate small molecule therapeutics

2017

Myotonic dystrophy type 1 (DM1) is a rare multisystemic neuromuscular disorder caused by expansion of CTG trinucleotide repeats in the noncoding region of the DMPK gene. Mutant DMPK transcripts are toxic and alter gene expression at several levels. Chiefly, the secondary structure formed by CUGs has a strong propensity to capture and retain proteins, like those of the muscleblind-like (MBNL) family. Sequestered MBNL proteins cannot then fulfill their normal functions. Many therapeutic approaches have been explored to reverse these pathological consequences. Here, we review the myriad of small molecules that have been proposed for DM1, including examples obtained from computational rational …

Derepressing muscleblind expression by miRNA sponges ameliorates myotonic dystrophy-like phenotypes in Drosophila

2016

AbstractMyotonic Dystrophy type 1 (DM1) originates from alleles of the DMPK gene with hundreds of extra CTG repeats in the 3′ untranslated region (3′ UTR). CUG repeat RNAs accumulate in foci that sequester Muscleblind-like (MBNL) proteins away from their functional target transcripts. Endogenous upregulation of MBNL proteins is, thus, a potential therapeutic approach to DM1. Here we identify two miRNAs, dme-miR-277 and dme-miR-304, that differentially regulate muscleblind RNA isoforms in miRNA sensor constructs. We also show that their sequestration by sponge constructs derepresses endogenous muscleblind not only in a wild type background but also in a DM1 Drosophila model expressing non-co…