Search results for "regulation"

Evaluation of metacognitive regulation skills in writing tasks in L1 and EFL in pre-service teachers

2020

The objective of this thesis is to diagnose the strategies of metacognitive control in writing of pre-service teachers (PSTs) in the deferred revision of two writing tasks in L1 (Spanish/Catalan) and English as a foreign language (EFL). Two exploratory studies were designed. In the first one, ninety-eight (N=98) PSTs took part they were split into higher (B2&C1) or lower (A1-B1) EFL proficiency and wrote either an essay (knowledge-transforming) or a summary (knowledge-telling) in their L1 or EFL. Texts were revised two days later so that text quality could be improved. The metacognitive control was assessed following mostly Allal's (2000) taxonomy. Each aspect of those changes or transforma…

Pierwszeństwo w polskim systemie prawnym

2017

The polish law system the institutions of priority and preemption are present in many different acts. They are relating with many diversified subjects. Despite of this, the legislator sometimes uses it a alternately. It makes a problem with definitions - in they are one institution or two. The other questions are following: why priority should be distinctive institution? Is it better for polish civil law procedure? What about differences between priority and preemption ? This article try to answer these problems by analysis of actual acts.

La regolazione di prezzo nel settore idrico: Proposte per un nuovo metodo tariffario

2011

Expectations And Mindsets Related To GDPR

2022

The aim of this qualitative case study is to examine the initial expectations and assumptions related to General Data Protection Regulation (GDPR) of the European Union from the perspectives of selected Finnish organizations: what were the initial expectations of GDPR, how were they adapted/refined over time, and what was the impact on organizational planning and resourcing. There are no precise earlier studies on the subject. The research question was:  What were the organizations’ initial expectations of GDPR - and how have they affected the efforts made?  GDPR can be described as an input that forms images, preconceptions and views among other things, through various active and passive c…

Product market regulation, innovation and productivity

2014

Several recent policy and academic contributions consider that liberalising product markets would foster innovation and growth. This paper analyses the innovation-productivity relationship at the industry-level for a sample of OECD manufacturing industries. We pay particular attention to the vertically-induced influence of product market regulation (PMR) of key input sectors of the economy on the innovative process of manufacturing and its consequences on productivity. We test for a differentiated effect of this type of PMR depending on whether countries are technological leaders or laggards in a given industry and for a given time period. Contrary to the most widespread policy claims, the …

ICT demand behaviour: An international comparison

2009

This study aims to provide some empirical explanations for the gaps in ICT diffusion between industrialized countries, especially European countries vis-à-vis the United States. The panel data cover eleven OECD countries: Austria, Denmark, Finland, France, Germany, Italy, Japan, the Netherlands, Spain, the United Kingdom and the United States. These annual macroeconomic data span the 1981-2005 period.The analysis provides some original results: (i) the impact on ICT diffusion of the level of education and market rigidities has changed over time. The correlation of ICT diffusion, positive with the level of education and negative with market rigidities, increased over time (in absolute terms)…

Building Situational Awareness of GDPR

2023

Because previous academic research does not comment sufficiently on how the relevant content of the European Union (EU) General Data Protection Regulation (GDPR has been properly communicated to the organisations, or how the situational awareness (SA) of GDPR has been built in the organisations, this qualitative empirical research was regarded as a valuable approach for gathering authentic research material on the practical bases of this phenomena. The aim of this empirical case study (CS) is to develop a picture of what processes organisations use to build SA of the GDPR requirements. To guide the CS, we asked how the SA for decision-making was constructed and how it was perceived in organ…

Optimizing management to enhance multifunctionality in a boreal forest landscape

2017

The boreal biome, representing approximately one-third of remaining global forests, provides a number of crucial ecosystem services. A particular challenge in forest ecosystems is to reconcile demand for an increased timber production with provisioning of other ecosystem services and biodiversity. However, there is still little knowledge about how forest management could help solve this challenge. Hence, studies that investigate how to manage forests to reduce trade-offs between ecosystem services and biodiversity are urgently needed to help forest owners and policy makers take informed decisions. We applied seven alternative forest management regimes using a forest growth simulator in a la…

Aplidin® induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 ph…

2006

Aplidin® is an antitumor agent in phase II clinical trials that induces apoptosis through the sustained activation of Jun N-terminal kinase (JNK). We report that Aplidin® alters glutathione homeostasis increasing the ratio of oxidized to reduced forms (GSSG/GSH). Aplidin® generates reactive oxygen species and disrupts the mitochondrial membrane potential. Exogenous GSH inhibits these effects and also JNK activation and cell death. We found two mechanisms by which Aplidin® activates JNK: rapid activation of Rac1 small GTPase and downregulation of MKP-1 phosphatase. Rac1 activation was diminished by GSH and enhanced by L-buthionine (SR)-sulfoximine, which inhibits GSH synthesis. Downregulatio…

Molecular Mechanisms of the Blockage of Glioblastoma Motility

2021

Glioblastoma (GBM) is the most common and lethal brain tumor. GBM has a remarkable degree of motility and is able to infiltrate the healthy brain. In order to perform a rationale-based drug-repositioning study, we have used known inhibitors of two small Rho GTPases, Rac1 and Cdc42, which are upregulated in GBM and are involved in the signaling processes underlying the orchestration of the cytoskeleton and cellular motility. The selected inhibitors (R-ketorolac and ML141 for Cdc42 and R-ketorolac and EHT 1864 for Rac1) have been successfully employed to reduce the infiltration propensity of GBM in live cell imaging studies. Complementarily, all-atom simulations have elucidated the molecular …