Search results for "relap"

Correlation between HHV-6 reactivation and multiple sclerosis disease activity.

2002

This study examined the association between HHV-6 infection and multiple sclerosis (MS) and the relationship between HHV-6 reactivation and disease activity. The frequency of HHV-6 genomic sequences in peripheral blood mononuclear cells (PBMCs), the incidence of plasma viremia (nPCR), the transcription of viral mRNA in PBMCs (RT-PCR), the presence of antiviral IgM and IgG class antibodies in the plasma (IFA) of 16 relapsing/remitting and secondary progressive MS patients were studied in comparison with clinical manifestations of the disease, magnetic resonance imaging (MRI) of brain, and serum interleukin (IL)-12 concentrations (ELISA). The prevalence of HHV-6 infection was significantly hi…

ANALISI DI RISCHIO DELL’IMPIANTO SPERIMENTALE “SELECTIVE PRODUCTION OF EXOTIC SPECIES” (SPES) DELL’INFN DI LEGNARO

Il progetto di ricerca denominato EURISOL (European Isotope Separation On-Line Radioactive Ion Beam Facility), che vede coinvolti i principali laboratori di ricerca nucleari europei, è rivolto allo studio di progettazione e fattibilità di un impianto per la produzione di fasci di nuclei radioattivi posizionati nella cosiddetta “terra incognita” della carta dei nuclidi. Lo scopo principale è l’esplorazione della materia esotica (nuclei caratterizzati da un eccesso difetto di neutroni), con le sue possibili implicazioni nell’ambito della ricerca di base della fisica nucleare, nelle applicazioni in campo medico e dell’astrofisica, e ancora nello studio dei materiali utilizzati nei reattori nuc…

Numerical simulation of the transient thermal-hydraulic behaviour of the ITER blanket cooling system under the draining operational procedure

2015

Abstract Within the framework of the research and development activities supported by the ITER Organization on the blanket system issues, an intense analysis campaign has been performed at the University of Palermo with the aim to investigate the thermal-hydraulic behaviour of the cooling system of a standard 20° sector of ITER blanket during the draining transient operational procedure. The analysis has been carried out following a theoretical-computational approach based on the finite volume method and adopting the RELAP5 system code. In a first phase, attention has been focused on the development and validation of the finite volume models of the cooling circuits of the most demanding mod…

Analysis of a Station Black-Out transient in SMR by using the TRACE and RELAP5 code

2014

The present paper deals with the investigation of the evolution and consequences of a Station Black-Out (SBO) initiating event transient in the SPES3 facility [1]. This facility is an integral simulator of a small modular reactor being built at the SIET laboratories, in the framework of the R&D program on nuclear fission funded by the Italian Ministry of Economic Development and led by ENEA. The SBO transient will be simulated by using the RELAP5 and TRACE nodalizations of the SPES3 facility. Moreover, the analysis will contribute to study the differences on the code predictions considering the different modelling approach with one and/or three-dimensional components and to compare the capa…

RELAP5-3D thermal hydraulic analysis of the target cooling system in the SPES experimental facility

2014

The SPES (Selective Production of Exotic Species) experimental facility, under construction at the Italian National Institute of Nuclear Physics (INFN) Laboratories of Legnaro, Italy, is a second generation Isotope Separation On Line (ISOL) plant for advanced nuclear physic studies. The UCx target-ion source system works at temperature of about 2273 K, producing a high level of radiation (10^5 Sv/h), for this reason a careful risk analysis for the target chamber is among the major safety issues. In this paper, the obtained results of thermofluid-dynamics simulations of accidental transients in the SPES target cooling system are reported. The analysis, performed by using the RELAP5-3D 2.4.2 …

Increased cerebrospinal fluid albumin and immunoglobulin A fractions forecast cortical atrophy and longitudinal functional deterioration in relapsing…

2017

Background: Currently, no unequivocal predictors of disease evolution exist in patients with multiple sclerosis (MS). Cortical atrophy measurements are, however, closely associated with cumulative disability. Objective: Here, we aim to forecast longitudinal magnetic resonance imaging (MRI)-driven cortical atrophy and clinical disability from cerebrospinal fluid (CSF) markers. Methods: We analyzed CSF fractions of albumin and immunoglobulins (Ig) A, G, and M and their CSF to serum quotients. Results: Widespread atrophy was highly associated with increased baseline CSF concentrations and quotients of albumin and IgA. Patients with increased CSFIgA and CSFIgM showed higher functional disabilit…

Simeprevir and daclatasvir for 12 or 24 weeks in treatment-naïve patients with hepatitis C virus genotype 1b and advanced liver disease

2017

Background & Aims: We investigated the efficacy and safety of simeprevir plus daclatasvir in treatment-naïve patients with chronic, genotype 1b hepatitis C virus infection and advanced liver disease, excluding patients with pre-defined NS5A resistance-associated substitutions. Methods: This phase II, open-label, single-arm, multicentre study included patients aged ≥18 years with advanced fibrosis or compensated cirrhosis (METAVIR F3/4). Patients with NS5A-Y93H or L31M/V resistance-associated substitutions at screening were excluded. Simeprevir (150 mg)+daclatasvir (60 mg) once daily was administered for 12 or 24 weeks; treatment could be extended to 24 weeks prior to or at the Week 12 v…

Efficacy of N-acetylcysteine in the prevention of alcohol relapse-like drinking: Study in long-term ethanol-experienced male rats

2021

Alcohol use disorders are chronic and highly relapsing disorders, thus alcoholic patients have a high rate of recidivism for drug use even after long periods of abstinence. The literature points to the potential usefulness of N-acetylcysteine (NAC) in the management of several substance use disorders probably due to its capacity to restore brain homeostasis of the glutamate system disrupted in addiction. However, there is little evidence in the case of alcohol. The aim of this study was to explore the potential anti-relapse efficacy of NAC using the alcohol deprivation effect (ADE) model in long-term experienced rats. Two experiments were performed in male Wistar rats to: (a) test the effic…

The Impact of Coconut Oil and Epigallocatechin Gallate on the Levels of IL-6, Anxiety and Disability in Multiple Sclerosis Patients

2020

Background: Due to the inflammatory nature of multiple sclerosis (MS), interleukin 6 (IL-6) is high in blood levels, and it also increases the levels of anxiety related to functional disability. Epigallocatechin gallate (EGCG) decreases IL-6, which could be enhanced by the anti-inflammatory effect of high ketone bodies after administering coconut oil (both of which are an anxiolytic). Therefore, the aim of this study was to assess the impact of coconut oil and EGCG on the levels of IL-6, anxiety and functional disability in patients with MS. Methods: A pilot study was conducted for four months with 51 MS patients who were randomly divided into an intervention group and a control group. The …

Oral Palmitoylethanolamide Treatment Is Associated with Reduced Cutaneous Adverse Effects of Interferon-β1a and Circulating Proinflammatory Cytokines…

2016

Palmitoylethanolamide (PEA) is an endogenous lipid mediator known to reduce pain and inflammation. However, only limited clinical studies have evaluated the effects of PEA in neuroinflammatory and neurodegenerative diseases. Multiple sclerosis (MS) is a chronic autoimmune and inflammatory disease of the central nervous system. Although subcutaneous administration of interferon (IFN)-β1a is approved as first-line therapy for the treatment of relapsing–remitting MS (RR-MS), its commonly reported adverse events (AEs) such as pain, myalgia, and erythema at the injection site, deeply affect the quality of life (QoL) of patients with MS. In this randomized, double-blind, placebo-controlled study,…