Search results for "relation"
showing 10 items of 10542 documents
Response and Recovery of Brain Acetylcholinesterase Activity in the European Eel,Anguilla anguilla,Exposed to Fenitrothion
1998
European eel (Anguilla anguilla) were exposed to sublethal fenitrothion concentrations in a continuous flow-through system for 4 days. Brain acetylcholinesterase (AChE) activity was evaluated after 2, 8, 12, 24, 32, 48, 56, 72, and 96 h pesticide exposure. Results indicated that AChE activity in eel brains decreased as the concentration of fenitrothion increased. The pesticide induced significant inhibitory effects on the AChE activity ofA. anguilla,ranging from >40% inhibition at a sublethal concentration of 0.02 ppm to >60% inhibition at a sublethal concentration of 0.04 ppm. Eel were exposed to both fenitrothion concentrations for 96 h and then allowed a period of recovery in pesticide-f…
Human Embryonic Stem Cell Derived Hepatocyte-Like Cells as a Tool for In Vitro Hazard Assessment of Chemical Carcinogenicity
2011
Hepatocyte-like cells derived from the differentiation of human embryonic stem cells (hES-Hep) have potential to provide a human relevant in vitro test system in which to evaluate the carcinogenic hazard of chemicals. In this study, we have investigated this potential using a panel of 15 chemicals classified as noncarcinogens, genotoxic carcinogens, and nongenotoxic carcinogens and measured whole-genome transcriptome responses with gene expression microarrays. We applied an ANOVA model that identified 592 genes highly discriminative for the panel of chemicals. Supervised classification with these genes achieved a cross-validation accuracy of > 95%. Moreover, the expression of the response g…
Induction of apoptosis and inhibition of cell growth in human hepatocellular carcinoma cells by COX-2 inhibitors
2005
The aim of the present study was to examine the effects of nonselective (indomethacin) and selective cyclooxygenase-2 (COX-2) inhibitors (NS-398, nimesulide, and CAY10404) on cell growth, cell cycle distribution, and apoptosis in three human hepatocellular carcinoma cell lines (HepG2, HuH-6, and HA22T/VGH) with different characteristics of differentiation and biological behavior. The four COX inhibitors showed a dose-dependent growth-inhibitory effect in all the cell lines. No substantial arrests in the progression of the cells through the cell cycle were observed after treatment of HuH-6 or HA22T/VGH for 48 h with the various inhibitors. On the other hand, there were significant increases …
Cytotoxic effects and degradation products of three mycotoxins: Alternariol, 3-acetyl-deoxynivalenol and 15-acetyl-deoxynivalenol in liver hepatocell…
2015
This work is focused in studying the cytotoxic effects on HepG2 cells of the mycotoxins alternariol (AOH), 3-acetyl-deoxynivalenol (3-ADON) and 15-acetyl-deoxynivalenol (15-ADON) by the MTT assay, as well as in the identification of the degradation products and/or metabolites originated after treatment by liquid chromatography tandem mass spectrometry (LC-MS/MS) equipment and extracted from culture media. HepG2 cells were treated at different concentrations over 24, 48 and 72 h. The IC50 values were from 65 to 96 μM, from 3.6 to 6.2 μM and from 5.2 to 8.1 μM for AOH, 3-ADON and 15-ADON, respectively. Among all three mycotoxins assayed, deoxynivalenol (DON) derivated presented the highest to…
Visegrad Euroscepticism: Discursive Nodal Points in Eurosceptic Discourses Surrounding External Actions of the European Union
2018
Increasing support for Eurosceptic parties and movements can be observed in the European Union’s (EU) member states since 2009, when the economic crisis heavily affected the continent. This process has happened also within Central and Eastern European countries, especially in Poland, the Czech Republic, Slovakia and Hungary (collectively referred to as the Visegrad Group countries, or V4 for short). The goal of this paper is an analysis of far-right Eurosceptic politicians and their attitudes towards EU external actions. Using the Thomas Diez concept of discursive nodal points (DNPs) and examining European Parliament (EP) debates, literature about V4 Euroscepticism and media reports, this p…
Pressure–volume relationship by pharmacological stress cardiovascular magnetic resonance
2021
Abstract Background. The variation between rest and peak stress end-systolic pressure-volume relation (ΔESPVR) is an index of myocardial contractility, easily obtained during routine stress echocardiography and never tested during dipyridamole stress-cardiac magnetic resonance (CMR). We assessed the ΔESPVR index in patients with known/suspected coronary artery disease (CAD) who underwent dipyridamole stress-CMR.Methods. One-hundred consecutive patients (24 females, 63.76±10.17 years) were considered. ESPVR index was evaluated at rest and stress from raw measurement of systolic arterial pressure and end-systolic volume by biplane Simpson’s method. Results. The ΔESPVR index showed a good inte…
How to communicate between surgeon and intensivist?
2020
Purpose of review Communication and teamwork are essential to enhance the quality of care, especially in operating rooms and ICUs. In these settings, the effective interprofessional collaboration between surgeons and intensivists impacts patients' outcome. This review discusses current opinions and evidence for improving communication strategies and the relationship between surgeons and intensivists/anesthesiologist. Recent findings Effective teamwork has been demonstrated to improve patient outcome and foster healthier relationships between professionals.With the expansion of new medical superspecialist disciplines and the latest medical developments, patient care has been put through a pr…
Lasciare che l'altro sia. Uno sguardo fenomenologico-ermeneutico sull’autentico aver-cura.
2023
Starting from the authentic direction of care indicated by Heidegger, it is possible to trace a model of caring for the other that is non-intrusive and authentically paves the way for inclusiveness. It presents itself as a phenomenon whose essence is relationality: it is a phenomenal observation that tells us that being in the world is always a being among things and in relationship with others and care always takes place as a relationship that connects us in the world. The authentic direction of care is the one in which one knows how to conserve the other in its essence by guarding and cultivating it, the inauthentic interpretation is instead the one in which one relates to things and rela…
La première rencontre du corps malade en contexte de soins infirmiers : la relation de soin : une expérience ultime, du sensible au social
2016
Our study focuses on nursing care with a first approach based on human body and emotions through the teaching context in the sensitive hospital environment. The nursing student is a central point of our research as he lives a unique sensitive and interpersonal experience within his own body in a social setting imbued with symbolism. He perceives health care community through his five senses which inform and direct him, but also may destabilize him. We decided to base our study on the information and communication sciences thanks to a sensitive, sensorial and symbolic problematisation and through a multidisciplinary conceptualization based on different theoretical approaches, symbolic intera…
Carlo Scarpa e la sala del dubbio di palazzo Abatellis
2016
Questo articolo descrive, da un disegno di studio e da foto d'archivio, la sala del dubbio in divenire al processo di progettazione. E' uno sguardo alla realizzazione di Scarpa con la consapevolezza che le forme e gli allestimenti di palazzo Abatellis, stabiscono alla scala di dettaglio; "raccontare" di possibili somiglianze tra il dispositivo e le relazioni spaziali che si instaura con gli occhi del visitatore. This paper describes, from a study design and the photo archive, the challenge of the lost set-up in the making that the design process. It's a look at the making Scarpa with the knowledge that forms and exhibitions for Abatellis palace, established the scale of detail; "recount" of…