Search results for "relation"
showing 10 items of 10542 documents
Spectral Properties of Partial *-Algebras
2010
We continue our study of topological partial *algebras focusing our attention to some basic spectral properties. The special case of partial *-algebras of operators is examined first, in order to find sufficient hints for the study of the abstract case. The outcome consists in the selection of a class of topological partial *-algebras (partial GC*-algebras) that behave well from the spectral point of view and that allow, under certain conditions, a faithful realization as a partial O*-algebra.
El mito de Icario en la General estoria de Alfonso X
2013
This article studies the myth of Icarus as it is translated in the first part of Alfonso X's General estoria. Its analysis highlights aspects that are usually found in the mythographical episodes of the Alfonsine estoria, particularly linked with its possible sources and its internal characteristics. The latter ones are defined by the anonymity of the quote and an evident moral intention. Regarding the sources, if it is known that the mythography gets to the Alfonsine text through two paths, the gloss in the manuscripts and a mythographical work, the exact source or sources used by Alfonsine historians are still unidentified. I have begun searching where the elements that are found in no pr…
A Coherent derivation of an average ion model including the evolution of correlations between different shells
2013
We propose in this short note a method enabling to write in a systematic way a set of refined equations for average ion models in which correlations between populations are taken into account, starting from a microscopic model for the evolution of the electronic configura- tion probabilities. Numerical simulations illustrating the improvements with respect to standard average ion models are presented at the end of the paper.
On the limits to the long-period method in classical economics. A note
2001
On a first reading of Theory of Production, Kurz & Salvadori (1995) appear to confine the empirical domain of the long-period models of the classical theory of value and distribution to stationary economies with non-constant returns to scale and to growing economies with constant returns to scale. Such a reading is shown to be untenable since it merges the two levels of exploring the extension of a model and of testing a theoretical hypothesis. Conversely, the way Kurz & Salvadori tackle the problems of price dynamics and returns to scale in growing economies is shown to be compatible with what appears to be Sraffa's (implicit) strategy of research.
Some contributions to the theory of transformation monoids
2019
The aim of this paper is to present some contributions to the theory of finite transformation monoids. The dominating influence that permutation groups have on transformation monoids is used to describe and characterise transitive transformation monoids and primitive transitive transformation monoids. We develop a theory that not only includes the analogs of several important theorems of the classical theory of permutation groups but also contains substantial information about the algebraic structure of the transformation monoids. Open questions naturally arising from the substantial paper of Steinberg [A theory of transformation monoids: combinatorics and representation theory. Electron. J…
Informal Institutions and Democracy
2000
Informal institutions have grown in relevance for the analysis of new ‘third wave’ democracies. The research strategy receives its impetus from the debate on neo‐institutionalism theory, which offers a productive perspective for structuring the field of analysis. This article explains the distinguishing factors between formal and informal institutions. It addresses five basic types of informal institutions, examines the ways in which they function and discusses their relevance in terms of democracy theory. Each type is characterized by the way in which it enacts its respective means of political influence. The study distinguishes between forms of specific relationship (clientelism), of mate…
Inhibition of activated STAT5 in Bcr/Abl expressing leukemia cells with new pimozide derivatives.
2014
STATs are transcription factors acting as intracellular signaling after stimulation with cytokines, growth factors and hormones. STAT5 is also constitutively active in many forms of cancers, including chronic myelogenous leukemia, acute lymphoblastic leukemia and Hodgkin's lymphoma. Recently, literature reported that the neuroleptic drug pimozide inhibits STAT5 phosphorylation inducing apoptosis in CML cells. We undertook an investigation from pimozide structure, obtaining simple derivatives with cytotoxic and STAT5-inhibitory activity, two of them markedly more potent than pimozide.
SAR-studies of γ-secretase modulators with PPARγ-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer’s disease
2014
Abstract We present the design, synthesis and biological evaluation of compounds containing a 2-(benzylidene)hexanoic acid scaffold as multi-target directed γ-secretase-modulators. Broad structural variations were undertaken to elucidate the structure–activity-relationships at the 5-position of the aromatic core. Compound 13 showed the most potent activity profile with IC50 values of 0.79 μM (Aβ42), 0.3 μM (5-lipoxygenase) and an EC50 value of 4.64 μM for PPARγ-activation. This derivative is the first compound exhibiting low micromolar to nanomolar activities for these three targets. Combining γ-secretase-modulation, PPARγ-agonism and inhibition of 5-lipoxygenase in one compound could be a …
Efficiency of antidepressant drugs as monoamine reuptake inhibitors: analysis of the hydrophobicity influence using biopartitioning micellar chromato…
2004
The reuptake blockade of biogenic amines by antidepressants is related not only to their therapeutics effects, but also to their side effects and potential drug-drug interactions. As an alternative to classical quantitative structure-activity relationships studies, in this work we propose different quantitative retention-activity relationships (QRAR) models that are able to describe the monoamine reuptake inhibition by antidepressants. The retention of compounds is measured using a biopartitioning micellar chromatography (BMC) system that can simulate the same hydrophobic, electronic and steric molecular interactions as those that condition drug activity. Since all the compounds considered …
The Correlation Between Abnormal Uterine Artery Flow in the First Trimester and Genetic Thrombophilic Alteration: A Prospective Case-Controlled Pilot…
2020
Introduction. Evaluation of the first trimester uterine artery flow can predict the development of obstetrical complications. A genotype, making women prone to microthrombi. constitutes the main known susceptibility factor for anomalous development of placenta. Our aim was to study whether polymorphisms of 10 genes leading to blood clotting abnormalities are related to abnormal uterine artery blood flow in the first trimester, and may predict placenta-related diseases. Material and methods. In primary analyses we included 19 singleton pregnancies with abnormal blood flow in the uterine arteries during the first trimester of gestation, and 24 matched control with normal flow patterns. All pa…