Search results for "relationship"
showing 10 items of 3616 documents
Modulation of voltage-gated Na+ and K+ channels by pumiliotoxin 251D: A “joint venture” alkaloid from arthropods and amphibians
2008
Abstract Certain amphibians provide themselves with a chemical defense by accumulating lipophilic alkaloids into skin glands from dietary arthropods. Examples of such alkaloids are pumiliotoxins (PTXs). In general, PTXs are known as positive modulators of voltage-gated sodium channels (VGSCs). Unlike other PTXs, PTX 251D does not share this characteristic. However, mice and insect studies showed that PTX 251D is highly toxic and to date the basis of its toxicity remains unknown. In this work, we searched for the possible target of PTX 251D . The toxin was therefore made synthetically and tested on four VGSCs (mammalian rNa v 1.2/β 1 , rNa v 1.4/β 1 , hNa v 1.5/β 1 and insect Para/tipE ) and…
Retention pharmacokinetic and pharmacodynamic parameter relationships of antihistamine drugs using biopartitioning micellar chromatography
2001
Abstract Antihistamines are drugs which act by competitive inhibition of the H1 or H2 histamine receptors. Little has been known about their clinical pharmacokinetics and biological responses until the last few years. In this paper, we propose quantitative retention–activity relationship, QRAR, models based on the retention data of antihistamines in a biopartitioning micellar chromatography (BMC) system using a Brij35 mobile phase for describing pharmacokinetic parameters such as half-life and volume of distribution, or the pharmacodynamic parameters, therapeutic plasma levels, lethal doses and drug-receptor dissociation constant. The predictive ability of these models is statistically vali…
New-stage discharge relationship for weirs of finite crest lenght
2014
AbstractThe flow process of weirs of finite crest length is analyzed on the basis of the dimensional analysis and incomplete self-similarity theory. The crest length is incorporated in the functional stage-discharge relationship for weirs of finite crest length. The theoretically deduced stage-discharge formula was then calibrated using the experimental data compiled in this research. According to the current experimental data it is also concluded that the performance of the proposed stage-discharge formula is better than the previous dimensional stage-discharge formulae. Also, the proposed stage-discharge formula is applicable for all types of the weirs, i.e., long-crested, broad-crested, …
Booster vaccination after neonatal priming with acellular pertussis vaccine.
2010
After a birth dose of acellular pertussis (aP) and diphtheria (DT)aP-hepatitis B virus (HBV)-inactivated polio vaccine (IPV)/ Haemophilus influenza type b (Hib) at 2, 4, and 6 months, a booster dose of DTaP-HBV-IPV/Hib at 12 to 23 months induced strong anti-pertussis booster responses. Thus, neonatal aP priming did not lead to immune tolerance to pertussis antigens. However, it elicited bystander interference on HBV, Hib, and diphtheria responses.
INNOVAZIONE DEI MATERIALI NATURALI: TERRA E NANOTUBI DI ARGILLA PER UNA SFIDA SOSTENIBILE
2019
All’interno del dibattito culturale che vede la questione ambientale come prioritaria e con riferimento a studi e ricerche che negli ultimi anni hanno promosso materiali compositi a base di terra cruda, gli Autori, consapevoli della necessità che il rapporto fra Progetto e Materia debba assumere una nuova centralità supportato dalle specificità della Tecnologia dell’Architettura, illustrano le risultanze di una sperimentazione che ha l’obiettivo di migliorare le prestazioni della terra cruda con l’apporto delle nanotecnologie, sviluppando un ‘nuovo materiale’ con una ridotta embodied energy e una ridotta quantità di emissioni di CO2 in atmosfera.
ACQUISITION OF STUDENT SCIENTIFIC INQUIRY SKILLS: CENTRALISED EXAMINATION RESULTS IN CHEMISTRY
2016
From 2011, the new educational standard in Latvia in the framework of the educational reform on the centralised examination (CE) in chemistry stipulates students to demonstrate the inquiry skills they have mastered. The purpose of this study is to find out the students’ inquiry skills by analysing the CE results in chemistry. This study addresses the following research questions: (a) To what extent are the centralised examination inquiry skills measured according to the standard outcomes? (b) What information on how students have mastered the inquiry skills in chemistry is available from the CE results for the period of 2011-2015? (c) Does measuring the inquiry skills using inquiry-based la…
Smartphones y caída libre: Diseño y evaluación de una experiencia práctica
2019
RESUMEN: Este trabajo presenta el diseño y evaluación de una experiencia práctica sobre el movimiento de caída libre basada en la utilización de smartphones para comprobar si el aprendizaje de los estudiantes sobre este movimiento mejora al utilizar este tipo de dispositivos móviles. La evaluación de la experiencia práctica se ha realizado mediante un diseño pre-post en el que 47 estudiantes, matriculados en la asignatura 'Física y Química' de 4º de ESO, han contestado a un cuestionario con 6 preguntas de respuesta libre. Los resultados muestran que la experiencia práctica propuesta es eficaz ya que se obtiene una mejora estadísticamente significativa entre el pre-test y el post-test, tanto…
Theoretical and Pragmatic Approaches of Undeclared Work in Romania
2014
Abstract Undeclared work in Romania is a very widespread phenomenon. The published information about the employment relationship worries us, having regard to the damage recorded by undeclared work. For this reason, without claiming a comprehensive approach, through this article we try to give answer to questions such as: What is undeclared work and how it is manifested in Romania? What is the level of undeclared work in Romania? What are the main causes of undeclared work? What measures can be taken to prevent, detect and stop undeclared work? What is the experience of other countries to combat undeclared work?
Effect of plastic deformation on photoluminescence of ZnTe bulk monocrystals
1999
Abstract In this work ZnTe bulk single crystals have been deformed by axial compression with the aim of analyzing the luminescence properties related to intrinsic structural defects like dislocations. Plastic deformation greatly decreases the overall PL response, near-band-edge luminescence as well as deep level-related emissions. Results indicate a close relationship between the so-called Y1 and Y2 bands and the density of generated dislocations. Plastic deformation also produces an emission band at 603 nm whose intensity is proportional to the amount of introduced deformation.
Connections Between Topology and Macroscopic Mechanical Properties of Three-Dimensional Open-Pore Materials
2018
This work addresses a number of fundamental questions regarding the topological description of materials characterized by a highly porous three-dimensional structure with bending as the major deformation mechanism. Highly efficient finite-element beam models were used for generating data on the mechanical behavior of structures with different topologies, ranging from highly coordinated bcc to Gibson–Ashby structures. Random cutting enabled a continuous modification of average coordination numbers ranging from the maximum connectivity to the percolation-cluster transition of the 3D network. The computed macroscopic mechanical properties–Young's modulus, yield strength, and Poisson's ratio–co…