Search results for "relationship"
showing 10 items of 3616 documents
Suppliers and Strategies for Upgrading in Global Production Networks: The Case of a Supplier to the Global Automotive Industry in a High-cost Location
2009
The paper analyses the possibilities for a Norwegian supplier incorporated into global production networks in the automotive industry to perform knowledge upgrading and innovation activity. A consistent finding is that different departments of the supplier are parts of different types of global network. The serial production of the supplier is distinguished by quasi-hierarchical governance by customers and by lean forms of work organization in the production that stimulate continuous, incremental upgrading of the production process. The development department has network relations with customers and learning forms of work organization, which triggers production and functional upgrading. The…
Work, power and learning in a risk filled occupation
2011
In this article we describe various ways in which power is exercised between personnel in a hospital operating theatre. We aim to investigate how the forms of discursive power and workplace learning are intertwined with each other by utilizing an ethnographic approach in the fieldwork. Our data were collected mainly through observations and interviews with surgical residents, physicians and nurses. In the article we describe the delicate ways in which power is exercised and resisted in everyday practices. We argue that there is a close relationship between learning and manifestations of power, together with the various forms of these manifestations and the restrictions that may be placed o…
Comparing the Capabilities of Mobile Platforms for Business App Development
2015
Businesses increasingly embrace the possibilities of mobile computing. While there is broad advice for app developers in general, development of apps for enterprises is hardly covered. Business apps support internal processes and contribute to customer relationship management. The heterogeneity of platforms for mobile devices makes development difficult. At the same time, companies seek to support several platforms with their apps to maximize customer acceptance and to support the platforms best suited for their employees. Aiming at improving the knowledge on business app development, we present a framework for assessing mobile platforms. For this purpose, we have developed a distinct set o…
Structural basis for the potential antitumour activity of DNA-interacting benzo[kl]xanthene lignans
2010
The biological properties and possible pharmacological applications of benzo[kl]xanthene lignans, rare among natural products and synthetic compounds, are almost unexplored. In the present contribution, the possible interaction of six synthetic benzo[kl]xanthene lignans and the natural metabolite rufescidride with DNA has been investigated through a combined STD-NMR and molecular docking approach, paralleled by in vitro biological assays on their antiproliferative activity towards two different cancer cell lines: SW 480 and HepG2. Our data suggest that the benzo[kl]xanthene lignans are suitable lead compounds for the design of DNA selective ligands with potential antitumour properties.
Flavonols and flavan-3-ols as modulators of xanthine oxidase and manganese superoxide dismutase activity.
2014
Experiments were performed to assess the dose-dependent effects of quercetin, kaempferol, (+) catechin, and (-) epicatechin on superoxide radical production through the modulation of manganese superoxide dismutase and xanthine oxidase activities. The experiments were carried out at flavanoid concentrations ranging from 1 µM to 100 µM. This investigation highlighted that flavonols induced opposite effects on superoxide radical production at different doses, i.e. pro-oxidant at the highest concentration (100 µM) and anti-oxidant at the lowest concentration (1 µM). Similar behaviors were observed for xanthine oxidase with flavan-3ols. The diastereoisomer (the catechin) acted as a stronger radi…
Sildenafil protects epithelial cell through the inhibition of xanthine oxidase and the impairment of ROS production
2009
Recent reports suggest that xanthine oxidase (XO), a modified form of the native xanthine dehydrogenase enzyme, plays an important role in various forms of ischemic and vascular injuries, inflammatory diseases, and chronic heart failure. The XO inhibitors allopurinol and its oxidation product oxypurinol held considerable promises in the treatment of these conditions both in experimental animals and in human clinical trials. More recently, an endothelium-based protective effect of sildenafil, a well-known type-5 phosphodiesterase inhibitor, has been reported in preconditioning prior to ischemia/reperfusion in healthy human subjects. Based on the structural similarities between allopurinol an…
Toxicity of fatty acid hydroperoxides towards Yarrowia lipolytica: Implication of their membrane fluidizing action
2007
Abstract Linoleic acid hydroperoxide (HPOD), substrate of hydroperoxide lyase, an enzyme of the lipoxygenase pathway, can be transformed into many aromatic compounds, the so-called “green notes”. The presence of linoleic acid hydroperoxide in the culture medium of Yarrowia lipolytica, the yeast expressing the cloned hydroperoxide lyase of green bell pepper, undoubtedly exerted an inhibition on the growth and a toxic effect with 90% of yeast cells died after 120 min of exposition in 100 mM HPOD solution. The increase in cell membrane fluidity evaluated by measuring fluorescence generalized polarization with the increasing concentration of HPOD in the medium confirmed the fluidizing action of…
Gender Relations in Postmodern Society: Perceptions and Attitudes of Young Students About Power Relations in Couples
2019
Este artículo presenta resultados de un proyecto que nace de la inquietud de un instituto público de Educación Secundaria Obligatoria (ESO) por conocer cómo son las relaciones de género entre su alumnado. El marco teórico que contribuye a contextualizar los resultados expuestos está centrado en las teorías del poder, del amor y los afectos, y del impacto de las TIC. El objetivo del estudio es diagnosticar cómo se expresan las relaciones de poder en las parejas en centros educativos. De esta manera, se espera poder obtener y plantear elementos que permitan a los centros generar estrategias para la acción futura a partir de los marcos emocionales de las relaciones de poder en las parejas. Con…
Forte baisse de l'embauche des jeunes en Bourgogne
2010
Réalisée en Bourgogne depuis vingt-cinq ans, l'enquête Insertion dans la vie active constitue un outil particulier et unique qui donne la possibilité de suivre l'évolution des conditions d'entrée des jeunes sur le marché du travail. Cette note présente les résultats de la dernière interrogation menée en février 2009, et donne un aperçu de la transition de l'école à l'emploi. En Bourgogne, 7 400 élèves et 4 800 apprentis âgés de 20 ans en moyenne, ont été interrogés sur leur situation professionnelle. Sept mois après la fin des études, 47 % des filles et 55 % des garçons sont salarié-e-s en février 2009. Les jeunes de la région n'échappent pas à la crise économique internationale illustrée p…
De la formation à l'emploi : une transition difficile
2006
Pour connaître le devenir des anciens élèves et apprentis, le ministère de l'Éducation nationale réalise des enquêtes depuis de nombreuses années, avec l'appui des établissements scolaires et des centres de formation d'apprentis. Cette note présente les résultats des dernières enquêtes effectuées en 2005, qui appréhendent les situations des jeunes sept mois après la fin de leurs études en Bourgogne.