Search results for "relationship"

showing 10 items of 3616 documents

Current development of CFTR potentiators in the last decade

2020

Cystic fibrosis (CF) is a genetic disorder produced by the loss of function of CFTR, a main chloride channel involved in transepithelial salt and water transport. CFTR function can be rescued by small molecules called "potentiators" which increase gating activity of CFTR on epithelial surfaces. High throughput screening (HTS) assays allowed the identification of new chemical entities endowed with potentiator properties, further improved through medicinal chemistry optimization. In this review, the most relevant classes of CFTR potentiators developed in the last decade were explored, focusing on structure-activity relationships (SAR) of the different chemical entities, as a useful tool for t…

congenital hereditary and neonatal diseases and abnormalitiesHigh-throughput screeningGlycineComputational biologyQuinolonesVX-770Aminophenols01 natural sciencesCystic fibrosisCystic fibrosisSmall Molecule LibrariesStructure-Activity Relationship03 medical and health sciencesDrug DiscoverymedicineHumansCFTR potentiatorCFTRLoss function030304 developmental biologyPharmacology0303 health sciencesWater transportbiology010405 organic chemistryChemistryOrganic ChemistryCFTR potentiatorsBiological activityGeneral MedicineTriazolesPotentiatormedicine.diseaseCystic fibrosis transmembrane conductance regulator0104 chemical sciencesCystic fibrosiMutationChloride channelbiology.proteinCystic fibrosis transmembrane conductance regulatorEuropean Journal of Medicinal Chemistry
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Immediacy and distance in teacher talk—A comparative case study in German elementary- and outdoor school-teaching

2017

This case study examines authentic speech acts by a German primary school teacher in the classroom context and the outdoor learning location of a forest. The study will compare the degree of linguistic immediacy or distance in these two contexts, respectively. Once a week, the class is doing “outdoor school” [Draußenschule] in places of natural or cultural interest near to their school. The structural change in the teaching environment means a change in the communication setting. The question arises if the teacher speaks to the students differently indoors than outdoors. The theoretical reference framework for the study is provided by the linguistic model “language of immediacy and language…

conversation analysisOutdoor educationmedia_common.quotation_subjectComparative caseDiscourse analysisoutdoor school050801 communication & media studiesContext (language use)EducationGerman0508 media and communicationsteacher–child relationshipteacher talkPedagogyImmediacyComputingMilieux_COMPUTERSANDEDUCATIONConversationL7-991media_common060201 languages & linguistics05 social sciencesEducation (General)06 humanities and the artslanguage.human_languagedraußenschuleConversation analysislanguage immediacy0602 languages and literaturelanguagePsychologyCogent Education
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L’ADULTO COME SPECCHIO. MODALITÀ COMUNICATIVE E APPRENDIMENTO

2021

Numerose ricerche sull’infanzia condotte a partire dal secolo scorso, hanno mostrato come i bambini, fin dai primi mesi di vita, siano attivi e propositivi nella interazione con gli altri esseri umani. In una prospettiva educativa, di promozione dei processi di apprendimento e di sostegno alla costruzione di una immagine di sé positiva e fiduciosa nelle proprie potenzialità, sono di grande importanza le modalità comunicative e relazionali degli adulti significativi. A tali modalità farò riferimento nel mio contributo, soffermandomi sul rispecchiamento verbale e non verbale, nelle sue diverse forme, approfondendone le ragioni teoriche e metodologiche e riflettendo su come possa attuarsi una …

corpo e linguaggiodevelopment and learningbody and languageverbal and non-verbal mirroringsviluppo e apprendimentoAdult-child relationshiprispecchiamento verbale e non verbale.Relazione adulto-bambinomodalità comunicative in ambito educativoSettore M-PED/01 - Pedagogia Generale E Socialecommunication methods in the educational field
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Nuove coppie, nuove unioni. Psicologia delle relazioni amorose moderne.

2022

couples relationships families community intervention
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Le BCC e la crisi internazionale: un’analisi comparata per macro regioni

2014

La crisi nanziaria internazionale, che ha assunto connotati maggiormente strutturali a partire dal 2009, ha prodotto e etti disomogenei sulle performance delle banche di credito cooperativo italiane, manifestandosi con maggiore intensità sulle BCC operanti nel Sud Italia. La crisi nanziaria ha messo a nudo talune fragilità endogene, riconducibili essenzialmente al ristretto ambito di operatività, alla carenza di competenze in comparti di attività diversi dall’intermediazione creditizia tradizionale, nonché all’orientamento quasi esclusivo verso la clientela di piccole dimensioni. Per contrastare gli e etti della crisi globale appare necessario un processo di innovazione che passi attra…

crisi finanziaria banche locali relationship banking
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Más allá de Marx: postobrerismo y posmarxismo. Una revisión de los fundamentos teóricos de la multitud y el pueblo

2018

The article is a synthetic essay that exposes the main theoretical lines of the postmarxist approach of Laclau and Mouffe, on the one hand, and the autonomist post-operaism of Negri, Hardt, Virno, etc., on the other hand. These theories are conceived as attempts to rationalize current political bets by various political sectors and social movements. It analyzes both argumentative strategies from «orthodox» Marxism and the structure / superstructure relationship; and the forms of constitution of new subjectivities. It compares the theoretical fundamentals of hegemonic articulations and counter-power experiences. It discusses, likewise, the scope and limitations of the categories of «people» …

critical and transformative incorporation into state institutions [the scope and limitations of the categories of «people» and «multitude» and their specifics forms of political action]multitudeand the autonomist post-operaism of Negrimobilization. 59 721137-7038 8537 Arxius de sociologia 493757 2018 38 6508345 Más allá de Marx: postobrerismo y posmarxismo. Una revisión de los fundamentos teóricos de la multitud y el pueblo PizziVirnopost-marxismposfordismoUNESCO::SOCIOLOGÍAand the forms of constitution of new subjectivities. It compares the theoretical fundamentals of hegemonic articulations and counter-power experiences. It discussesAlejandro The article is a synthetic essay that exposes the main theoretical lines of the postmarxist approach of Laclau and Mouffemultitudposmarxismoon the other hand. These theories are conceived as attempts to rationalize current political bets by various political sectors and social movements. It analyzes both argumentative strategies from «orthodox» Marxism and the structure / superstructure relationshippostobrerismo y posmarxismo. Una revisión de los fundamentos teóricos de la multitud y el pueblo Pizzi [1137-7038 8537 Arxius de sociologia 493757 2018 38 6508345 Más allá de Marx]etc.postfordism:SOCIOLOGÍA [UNESCO]movilizaciónpopulismand exodus and nomadismHardtpost-operaismon the other. populismoon the one handpostobrerismothe scope and limitations of the categories of «people» and «multitude» and their specifics forms of political action: critical and transformative incorporation into state institutionslikewise
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Geometrical and conformational preferences of the 9‐fluorenylmethoxycarbonyl‐amino moiety

2004

Structural parameters, originating from x-ray crystallographic data, have been compiled for 13 derivatives of amino acids, peptides and related compounds, which contain a total of 14 Fmoc-NH- moieties. For these moieties, molecular geometries and conformations--described by the omegao, theta1, theta2 and theta3' torsion angles--were analysed and compared with the corresponding parameters for the Z-NH- and Boc-NH-moieties (290 and 553, respectively). To gain a deeper insight into the conformational features of the Fmoc-NH- moiety, ab initio free molecule calculations were performed for fully relaxed minima. Also the potential energy surface as a function of the torsion angles (theta3', theta…

crystal structureStereochemistryAb initioMolecular ConformationCrystal structureCrystallography X-RayBiochemistryBoc amino protectionStructure-Activity RelationshipfluoreneStructural BiologyAb initio quantum chemistry methodsDrug DiscoveryMoleculeMoietyurethane geometryFmoc amino protectionAmino AcidsMolecular BiologyPharmacologyFluorenesMolecular StructureChemistryHydrogen bondab initio calculationsOrganic ChemistryHydrogen BondingGeneral MedicineZ amino protectionMolecular geometryPotential energy surfaceMolecular MedicineCrystallizationPeptidesN‐terminally protected peptidesJournal of Peptide Science
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1,1,3,3-Tetraethyl-5-nitroisoindoline

2019

The title compound, C16H24N2O2, previously obtained as a yellow oil, exhibits a rather low melting point close to room temperature 297–298 K). In the molecule, the isoindoline ring system is approximately planar and coplanar to the nitro group, forming a dihedral angle of 5.63 (15)°. In the crystal, only weak N—H...O and C—H...π interactions are observed, linking molecules into chains parallel to the [101] direction.

crystal structurebiologyIsoindolineCrystal structureDihedral angle010402 general chemistry010403 inorganic & nuclear chemistryRing (chemistry)biology.organism_classificationstructure–property relationshiporganic synthesis01 natural sciences0104 chemical sciencesCrystalCrystallographychemistry.chemical_compoundchemistryNitrolcsh:QD901-999TetraOrganic synthesislcsh:CrystallographyIUCrData
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Luonnossa liikkumisen kulttuuriset representaatiot : diskurssianalyysi suomalaisten luonnossa liikkumista käsittelevistä haastatteluista

2012

cultural contextscultural representationssport sociologyoutdoor activitiesluontoliikuntaoutdoor recreatinsDiskurssianalyysiluontoluontosuhdevirkistyskäyttörepresentaatiokulttuuriliikuntasosiologiarelationship with natureliikkuminen
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Intercultural Workplace Communication

2017

The workplace is a highly meaningful context for intercultural communication where persons who come from different countries, identify with different ethnic groups or speak different languages get to collaborate and develop relationships with one another. Needless to say, interpersonal communication in the workplace has always been a primary area of interest for intercultural communication research. Early scholarship focused on the preparation of U.S. military personnel, diplomats, business people, and missionaries for overseas assignments. However, the increasing pluralization of the social landscape has bolstered research endeavors. These days, the scope of intercultural workplace communi…

cultural identityWorkplace communicationCultural identityCommunication studiesWorkplace relationshipsworkplace relationshipskulttuurienvälinen viestintäInterpersonal communicationorganizational diversitytiimitkeskinäisviestintäCultural diversityPolitical sciencetyöelämäta518ryhmätviestintäComputingMilieux_THECOMPUTINGPROFESSIONkulttuurittyöpaikatworkplacesIntercultural communicationintergroup communicationintercultural communicationcultural diversitySocial psychologykulttuuri-identiteettiIntergroup communication
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