Search results for "relationship"
showing 10 items of 3616 documents
Ochrona socjalna sędziów sądów powszechnych
2018
Stereoselective Synthesis and Pharmacological Evaluation of 2,4-Bridged Piperidine Derivatives Designed to Activate the κ-Opioid Receptor
2021
Retinoids as a Perspective in Treatment of Alzheimer’s Disease
2010
<i>Background:</i> In the past, we demonstrated that the disintegrin metalloproteinase ADAM10 has α-secretase activity in vitro and in cultured cells. We also found out that moderate overexpression of this proteinase inhibits Aβ peptide production and prevents the formation of amyloid plaques in an Alzheimer’s disease (AD) mouse model. Moreover, it corrects early hippocampal defects like LTP impairment and increases cortical synaptogenesis. <i>Objective:</i> Upregulation of ADAM10 might be an alternative approach concerning AD therapy. Our current research therefore focuses on substances and/or pathways which regulate ADAM10 gene expression. <i>Methods:</i&g…
The role of mitochondria in sterigmatocystin-induced apoptosis on SH-SY5Y cells
2020
Mitochondria are cellular organelles involved in many crucial functions, such as generation of energy (ATP) and initiation of apoptosis. The aim of the present study was to evaluate the role of mitochondria in the toxicity induced by sterigmatocystin (STE), a mycotoxin produced by fungi of the genus Aspergillus, on SH-SY5Y cells. Our results showed that STE exposure decreased cell viability in a time- and concentration-dependent manner by MTT assay and caused mitochondrial dysfunction, as highlighted by the increase of STE cytotoxicity in cells forced to rely on mitochondrial oxidative phosphorylation. Furthermore, intracellular ATP depletion and increased mitochondrial reactive oxygen spec…
Relaxation induced by N-terminal fragments of chromogranin A in mouse gastric preparations.
2007
Abstract A definitive role for chromogranin A (CGA)-derived fragments in the control of the gastrointestinal smooth muscle contractility has not been yet established. The purpose of the present study was to evaluate, in vitro , the effects of the recombinant vasostatin 1–78 (VS-1), CGA 7–57 and CGA 47–66 on the mouse gastric mechanical activity, recording the changes of intraluminal pressure. VS-1, CGA 7–57 and CGA 47–66 produced concentration-dependent relaxations. Mouse anti-vasostatin-1 monoclonal antibody 5A8, recognising the region 53–57, abolished the relaxation induced by VS-1, indicating the specificity of the effect. The relaxation was significantly reduced by tetrodotoxin (TTX), b…
Humic acid reduces gonadotropin activity and hormonal sensitivity of frog oocytes
2005
The specific stimulatory effect of sturgeon Acipenser güldenstädti Br. gonadotropic hormone (GTH) on frog Rana temporaria L. oocyte maturation in vitro was investigated in relation to humic acid (HA) concentrations from 12.5 to 50 mg/l. HA was observed to bind to both the follicular membrane of the oocytes and the GTH molecule, reducing the oocytes' hormone sensitivity and maturation ability. It was also shown that HA inactivated GTH, lowering its specific ability to stimulate oocyte maturation.
Percepción del alumnado de Educación Secundaria sobre la mediación escolar en Castellón y Valencia
2016
La realidad social, en constante proceso de cambio, exige al sistema educativo un esfuerzo por actualizar las respuestas educativas frente a la mejora de la convivencia. Es en este contexto en el que la mediación ha dejado ver sus potencialidades educativas, ya que influye sobre la mejora del individuo, de las relaciones interpersonales y del clima escolar. No obstante, son escasas las investigaciones orientadas a conocer el impacto de la misma. En este artículo presentamos un estudio dirigido a conocer la valoración de la mediación atendiendo a las opiniones del alumnado de cinco centros educativos de secundaria de Valencia y cuatro de Castellón. Asimismo, se pretende detectar si existen d…
Individual Differences in Adolescents’ Civic Engagement: The Role of Civic Discussions with Parents and Environmental Sensitivity
2023
The main goal of the current study was to examine the direct and moderating effects of civic dis-cussions with parents and environmental sensitivity using both the total score and its specific di-mensions (i.e., Aesthetic Sensitivity, AES; Ease of Excitation, EOE; Low Sensitivity Threshold, LST) on youth civic engagement (attitudes and behaviours). The empirical analysis relied on a ques-tionnaire-based survey conducted on a sample of 438 adolescents (30% males), aged between 14 and 18 years (M = 16.50, SD = 1.36). We used a structural equation model (SEM) with latent vari-ables and the latent moderated structural equation (LMS) method to test our hypotheses. Our re-sults showed that civic …
Enhancement of Hydrolysis through the Formation of Mixed Heterometal Species: Al3+/CH3Sn3+ Mixtures
2013
ABSTRACT: The hydrolysis of mixed-metal cations (Al3+/CH3Sn3+) was studied in aqueous solutions of NaNO3, at I = 1.00 ± 0.05 mol·dm−3 and T = 298.15 K, by potentiometric technique. Several hydrolytic mixed species are formed in this mixed system, namely, Alp(CH3Sn)q(OH)r with (p, q, r) = (1, 1, 4), (1, 1, 5), (1, 1, 6), (2, 1, 4), (1, 2, 5), (1, 4, 11), (1, 3, 8), and (7, 6, 32). The stability of these species, expressed by the equilibrium: pAl3+ + qCH3Sn3+ + rOH− = Alp(CH3Sn)q(OH)r 3(p+q)−r, βpqr OH, can be modeled by the empirical relationship: log βpqr OH = −3.34 + 2.67p + 9.23(q + r). By using the equilibrium constant Xpqr relative to the formation reaction: pAl(p+q)(OH)r + q(CH3Sn)(p+q…
Interrelation between close teacher-student relationships and engagement : the case of Finnish preschools
2016
The study examined the interrelation between positive teacher-student relationships and teacher-reported level of engagement in Finnish preschool settings. Fifty preschool teachers working in Jyväskylä city area answered questionnaires in which they de-scribed 50 randomly selected students from their class (28 girls and 22 boys), one stu-dent for each teacher. Questionnaires consisted of two parts and measured the quality of teacher-child relationships and the level of children’s emotional and behavioural en-gagement. The results showed that quality of teacher-child relationships in the context of Finnish preschools is closely interrelated with the level of children’s engagement into the le…