Search results for "relationship"
showing 10 items of 3616 documents
Impact ofenvironmental variability on year-class strength of Baltic cod (Gadus morhua calliarias L.)
2014
Elektroniskā versija nesatur pielikumus
Design, synthesis and structure-activity relationship of 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of t…
2009
The biological importance of microtubules in mitosis and cell division makes them an interesting target for the development of anticancer agents. Small molecules such as benzo[b]furans are attractive as inhibitors of tubulin polymerization. Thus, a new class of inhibitors of tubulin polymerization based on the 2-(3′,4′,5′-trimethoxybenzoyl)-benzo[b]furan molecular skeleton, with electron-donating (Me, OMe or OH) or electron-withdrawing (F, Cl and Br) substituents on the benzene ring, was synthesized and evaluated for antiproliferative activity, inhibition of tubulin polymerization and cell cycle effects. Adding a methyl group at the C-3 position resulted in increased activity. The most prom…
On the mechanism of radiation synthesis of nanogels
2016
Radiation-engineered poly(N-vinyl pyrrolidone) nanogels are very interesting biocompatible nanocarriers for i.v. administration of therapeutics and contrast agents for bioimaging among other applications. Nanogels are usually produced upon irradiation of dilute aqueous polymer solutions. Under these conditions, the polymer radicals formed primarily react via intramolecular radical-radical combination forming intramolecular crosslinks. The manufacturing process is fast and effective and grants excellent control of particle size and simultaneous sterilization of the formed nanogels. Interestingly, primary amino groups and carboxyl groups, useful for (bio)conjugation, are also formed in a dose…
Child Well-Being in Times of Confinement: The Impact of Dialogic Literary Gatherings Transferred to Homes
2020
The COVID-19 pandemic has created an unexpected situation that has forced people to find educational alternatives to support learning and ensure child well-being. The need for practices that 'open doors' at home as a way to promote a quality education and to foster an environment of supportive relationships and a sense of community, has led to the in-depth analysis of successful educational actions, particularly the Dialogic Literary Gatherings (DLGs). The aim of this article is to show how the transference of DLGs to the home environment has had an impact on child subjective well-being in times of confinement, promoting a safe and supportive environment for learning, interacting, coexistin…
Perspectives on variation in species richness : area, energy and habitat heterogeneity
2011
Public relations and expectation theory : Introducing Relationship Expectation Theory (RET) for public relations
2021
Expectations provide organizations with information and cues about their stakeholders’ and publics’ values, interests, experiences, and knowledge. This chapter argues for a move that takes expectations beyond the current cursory level for different areas of public relations—reputation management, corporate responsibility, issues management, and legitimacy—toward explicit theoretical understanding and models for addressing expectations. The chapter introduces expectations as an intersecting phenomenon in public relations research and builds postulations for theorizing expectations in public relations by reviewing theories that address expectations in relationships, and by exploring different…
Maturity of Supply Chain as a Factor of Modeling the Relationships with Suppliers
2017
The following paper will discuss the level of maturity of the supply chain as a main factor that determines supplier relationships in the supply chain. The Ch. C. Piorier categorization was taken into consideration, where the development of supply chains includes 5 stages. Analysis of individual stages of supply chain maturity towards presented classification is a substitute for identifying different models of supplier relationships in the supply chain. In the supply chain, supplier relationships are established in order to enter into a partnership. Establishing relationships with suppliers in the supply chain appears to create by a stronger partnership. The capability of this cooperation d…
Sosiaalisen elämän kehykset : kampus-ohjelman opiskelijoiden sosiaalinen asema tuetussa aikuisopiskelussa ja vapaa-ajalla
2012
Synthesis and Structure-Affinity Relationships of Spirocyclic Benzopyrans with Exocyclic Amino Moiety
2019
σ1 and/or σ2 receptors play a crucial role in pathological conditions such as pain, neurodegenerative disorders, and cancer. A set of spirocyclic cyclohexanes with diverse O-heterocycles and amino moieties (general structure III) was prepared and pharmacologically evaluated. In structure-activity relationships studies, the σ1 receptor affinity and σ1:σ2 selectivity were correlated with the stereochemistry, the kind and substitution pattern of the O-heterocycle, and the substituents at the exocyclic amino moiety. cis-configured 2-benzopyran cis-11b bearing a methoxy group and a tertiary cyclohexylmethylamino moiety showed the highest σ1 affinity ( Ki = 1.9 nM) of this series of compounds. In…
Systematic conformational search analysis of the SRR and RRR epimers of 7-hydroxymatairesinol
2010
An extensive and systematic conformational search was performed on the two epimers of the natural lignan 7-hydroxymatairesinol (HMR), by means of a home-made Systematic Conformational Search Analysis (SCSA) code, designed to select more and more stable conformers through sequential geometry optimization of trial structures at increasing levels of calculation theory. In the present case, the starting molecular structures were selected by the semi-empirical AM1 method and filtered – i.e. decreased in number by choosing the more stable species – on the basis of their energy calculated by the HF method and the 6-31G(d) basis set. The geometries obtained were further refined by performing densit…