Search results for "relevance"

Clinical Practice Guideline on Melanoma From the Spanish Academy of Dermatology and Venereology (AEDV)

2020

El diagnóstico y tratamiento del melanoma en atención especializada es un campo en el que se han producido numerosos cambios. El objetivo de esta guía es ofrecer a los dermatólogos españoles una referencia para resolver las dudas clínicas más frecuentes basándose en la evidencia actual. Para la realización de esta guía se escogió a miembros del Grupo Español de Dermato-Oncología y Cirugía con experiencia en el tratamiento de estos tumores y con interés en participar en la elaboración de la guía. Se hizo una adaptación de las guías de práctica clínica existentes mediante el método ADAPTE: inicialmente se resumió el proceso de atención y se elaboraron las preguntas clínicas relevantes. Se sel…

Algunas reflexiones acerca de la stjue de 9 de julio de 2020 sobre los pactos novatorios en materia de cláusulas suelo

2021

The Sentence of the Court of Justice of the European Union of July 9, 2020 comes to answer the five questions that, in its preliminary question, the Court of First Instance and Instruction No. 3 of Teruel asks about the validity of the new agreements in the context of the floor clauses, establishing jurisprudential doctrine on this matter about which our Supreme Court had previously ruled in its Judgments of October 16, 2017, in the sense of considering the agreed floor clause null as a consequence of the novation agreement and, subsequently, those of April 11, 2018 and September 13, 2018 in the opposite direction, declaring that the novation agreement was valid. It is a long-awaited and in…

Fuzzy gender categories: How emotional expression influences typicality *The authors would like to thank Fieke Harinck for her help in conducting Stu…

2001

Social categories are conceived of as broad classes in which some instances are better exemplars than others, and non-necessary features are assumed to modulate typicality. This research investigated how various emotional expressions impact on gender categorization. Two concurrent measures - response latencies and prototypicality judgments - were collected and compared in three experiments. The results showed that emotional expressions of any kind are highly relevant in modulating females' category membership, while they are of less relevance in making a male more or less prototypical. These findings provide new insights into the relation between gender and emotional expressions.

Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages.

2013

Formation of cilia, microtubule-based structures that function in propulsion and sensation, requires Kif3a, a subunit of Kinesin II essential for intraflagellar transport (IFT). We have found that, Kif3a is also required to organize centrioles. In the absence of Kif3a, the subdistal appendages of centrioles are disorganized and lack p150(Glued) and Ninein. Consequently, microtubule anchoring, centriole cohesion and basal foot formation are abrogated by loss of Kif3a. Kif3a localizes to the mother centriole and interacts with the Dynactin subunit p150(Glued) . Depletion of p150(Glued) phenocopies the effects of loss of Kif3a, indicating that Kif3a recruitment of p150(Glued) is critical for s…

The Relevance of Sexual Biographies in Individuals Convicted of Child Sexual Abuse Offenses for the Development of Pedosexual Interests and Sexual Re…

2020

In the literature concerning the etiology of pedosexual interests, the potential role of early sexual experiences in childhood and adolescence has been discussed. Several studies demonstrated a link between own sexually abusive experiences in childhood and sexual offending later in life which tends to be even stronger for pedosexual offenders. Furthermore, some findings indicate associations between other developmental factors and deviant sexual interests in adulthood. For the present study, sexual biographical data of N = 223 imprisoned men convicted of sexual offenses against children from Austria was analyzed to retrospectively examine whether own sexually abusive experiences and non-abu…

The object-tool duality in mathematical modelling. A framework to analyze students’ appropriation of Sankey diagrams to model dynamic processes

2020

Students often do not experience the relevance of learning mathematics. This paper reports on an exploratory case study, in which a class of grade 8 students (n=35) was introduced to Sankey diagrams. The aim was to explore to what extent these students could appropriate Sankey diagrams, meaning: they could describe these as objects in themselves and they could use them to model and visualize phenomena relevant to them. Based on Cultural-Historical Activity Theory, we developed an analytical construct defined as the object-tool duality, coordinating mathematics as a set of objects and as a set of tools. The analysis of students’ answers showed that they could use these diagrams as tools to v…

Fallzahlplanung bei ophthalmologischen Studien*

2000

An essential aspect in the cooperation of clinic and biometry consists in designing of studies, e.g. during the preparation of grant applications or for review by official drug surveillance institutions. A central aspect in study planning is the design-adequate and well-documented prediction of sample size, which should be recommended for any intended study. Based on several examples for sample size planning in study designs, which are of common relevance for ophthalmology, guidelines are derived to enable clinical researchers to perform sample size planning on their own. The latter can be based on the various available software packages for sample size prediction.

Studying Utility of Personal Usage-History: A Software Tool for Enabling Empirical Research

2007

Managing personal information space and working context is complicated in computerized environment. One well-known cause for the problem is that digital information is superficially fragmented into different data types and structures. Several unifying approaches have been proposed to facilitate semantic connections between them. Particularly in personal information retrieval, temporal information has turned to be useful. Hence, in this article, we present an empirical research setting for studying the utility of representing personal usage-history in information retrieval by comparing it with more traditional hierarchical representation. The research setting is based on a software Tool that…

Understanding color vision, with comments on mind and matter

2012

Much is known about the mental and physical aspects of color vision. Color vision, therefore, is a paradigm well suited for the discussion of the relationship between mind and matter. The aim of the present chapter is to support the proposition that mental affairs cannot be adequately understood if their neurobiological aspects are neglected. Although it is possible to focus on fundamental problems of general relevance when discussing mind and matter, this chapter will deal with specific observations rather than general issues. The possibility of generalizations derived from empirical results is always limited. Provided the conditions under which these observations were made can be confirme…

2018

This article explores promising points of contact between philosophy and the expanding field of virtual reality research. Aiming at an interdisciplinary audience, it proposes a series of new research targets by presenting a range of concrete examples characterized by high theoretical relevance and heuristic fecundity. Among these examples are conscious experience itself, “Bayesian” and social VR, amnestic re-embodiment, merging human-controlled avatars and virtual agents, virtual ego-dissolution, controlling the reality/virtuality continuum, the confluence of VR and artificial intelligence (AI) as well as of VR and functional magnetic resonance imaging (fMRI), VR-based social hallucinations…