Search results for "renewal"
showing 10 items of 94 documents
ℓ1-Penalized Methods in High-Dimensional Gaussian Markov Random Fields
2016
In the last 20 years, we have witnessed the dramatic development of new data acquisition technologies allowing to collect massive amount of data with relatively low cost. is new feature leads Donoho to define the twenty-first century as the century of data. A major characteristic of this modern data set is that the number of measured variables is larger than the sample size; the word high-dimensional data analysis is referred to the statistical methods developed to make inference with this new kind of data. This chapter is devoted to the study of some of the most recent ℓ1-penalized methods proposed in the literature to make sparse inference in a Gaussian Markov random field (GMRF) defined …
MicroRNA-29b-1 is involved in self-renewal and fate decisions of human osteosarcoma 3AB-OS cancer stem cells
2014
Emerging evidence suggests that treatments targeting cancer stem cells (CSCs) within a tumor can halt cancer and improve patient survival. Moreover, identification of CSC-related MicroRNAs (miRNAs) would provide information for a better understanding of CSCs. miR-29 family is a class of miRNAs aberrantly expressed in multiple cancers. They are frequently down-regulated in osteosarcoma (OS), the most common form of childhood cancer with a potent metastasizing potential. 3AB-OS CSC, a human pluripotent CSC line by us produced from the human osteosarcoma MG63 cells (1) is a useful model to study CSC origin and roles (2). Previously, we have shown that in 3AB-OS CSCs miR-29b is potently down-re…
ON HIGH-SKILL AND LOW-SKILL EQUILIBRIA: A MARKOV CHAIN APPROACH
2006
In this paper we propose to study the dynamics of human capital accumulation by means of a Markov chain. We identify the conditions for the emergence of ergodic and nonergodic dynamics, and relate them to various characteristics of an economic system. The model may generate high-skill and low-skill equilibria as well as intermediate situations. Policy implications are also discussed.
Strongly super-Poisson statistics replaced by a wide-pulse Poisson process: The billiard random generator
2021
Abstract In this paper we present a study on random processes consisting of delta pulses characterized by strongly super-Poisson statistics and calculate its spectral density. We suggest a method for replacing a strongly super-Poisson process with a wide-pulse Poisson process, while demonstrating that these two processes can be set in such a way to have similar spectral densities, the same mean values, and the same correlation times. We also present a billiard system that can be used to generate random pulse noise of arbitrary statistical properties. The particle dynamics is considered in terms of delta and wide pulses simultaneously. The results of numerical experiments with the billiard s…
Polycomb-like 2 Associates with PRC2 and Regulates Transcriptional Networks during Mouse Embryonic Stem Cell Self-Renewal and Differentiation
2010
SummaryPolycomb group (PcG) proteins are conserved epigenetic transcriptional repressors that control numerous developmental gene expression programs and have recently been implicated in modulating embryonic stem cell (ESC) fate. We identified the PcG protein PCL2 (polycomb-like 2) in a genome-wide screen for regulators of self-renewal and pluripotency and predicted that it would play an important role in mouse ESC-fate determination. Using multiple biochemical strategies, we provide evidence that PCL2 is a Polycomb Repressive Complex 2 (PRC2)-associated protein in mouse ESCs. Knockdown of Pcl2 in ESCs resulted in heightened self-renewal characteristics, defects in differentiation, and alte…
Multicriteria Prioritization for Multistage Implementation of Complex Urban Renewal Projects
2015
Renewal projects on neighborhood scale often include several sub projects aiming at fulfill the different functions of urban areas, while public funds or activated public-private partnership can be insufficient to face the implementation of subprojects simultaneously. Therefore single parts of wider projects are frequently realized at different period of time, according to the availability of public funds or the interest of private partners in the most profitable projects. Although a major organizational effort of funding could be necessary, a more rational approach is required, which will be able to identify the most suitable sequence of realization ensuring the greatest advantage if non c…
Amyloid-Beta Induces Different Expression Pattern of Tissue Transglutaminase and Its Isoforms on Olfactory Ensheathing Cells: Modulatory Effect of In…
2021
Abstract Alzhèimer Disease (AD) is characterized by protein aggregates in the brain, including amyloid-beta (Aβ), a substrate for tissue transglutaminase (TG2). We assessed the effect of full native peptide of Aβ (1–42), the fragments (25–35 and 35–25) on TG2 expression and its isoforms (Long and Short) on mouse Olfactory Ensheathing Cells (OECs). The levels of cytoskeletal proteins, Vimentin and Glial Fibrillary Acid Protein, were also studied. The effect of the pre-treatment with Indicaxanthin on cell viability, total Reactive Oxygen Species, superoxide anion and apoptotic pathway activation was assessed. Since Nestin is co-expressed in pluripotent stem cells with cyclin D1, their levels …
Sustainability, Territorial Resources and Social Capital
2017
In Italy, in the last two decades, new methods of intervention in planning and land policies have been used, which focused more and more on territorial government, governance, development, cohesion and environmental sustainability. One of the main factors that has contributed to the dissatisfaction of the residents is the lack of quality in the towns, which has been more and more characterized by urban decay and by lack of services and gathering places. Giving back environmental, economic and social quality to degraded areas or recovering abandoned public spaces responds definitely to the concept of sustainable city limiting urban sprawl and reducing environmental impacts inherent in the bu…
How To Combine Ozone Therapies With Other Modalities For Maximum Efficacy
2018
In order to use Bio-Oxidative Therapies effectively, a small shift in thinking is needed. One needs to shift from Disease Literacy to Healing Literacy This shift in thinking leads to the inevitable conclusion that: Impaired Oxygen Signaling is the common denominator for all disease. Impaired Oxygen Signaling affects: • O2 driven energetics • O2's detergent function • O2's cellular repair function • O2's renewal function It is important to be aware of Oxygen's multiple functions in order to appreciate the importance of the role bio-oxidative therapies play in the reversal of disease conditions. In fact, no treatment…
DNA damage causes TP53-dependent coupling of self-renewal and senescence pathways in embryonal carcinoma cells.
2013
Recent studies have highlighted an apparently paradoxical link between self-renewal and senescence triggered by DNA damage in certain cell types. In addition, the finding that TP53 can suppress senescence has caused a re-evaluation of its functional role in regulating these outcomes. To investigate these phenomena and their relationship to pluripotency and senescence, we examined the response of the TP53-competent embryonal carcinoma (EC) cell line PA-1 to etoposide-induced DNA damage. Nuclear POU5F1/OCT4A and P21CIP1 were upregulated in the same cells following etoposide-induced G 2M arrest. However, while accumulating in the karyosol, the amount of OCT4A was reduced in the chromatin fract…