Search results for "respiratory tract diseases"
showing 10 items of 1015 documents
From sustainability to sustainable development: the role of food banks in food security in Uganda : a case study of the hunger project food bank - Mb…
2014
Master thesis in development management - University of Agder 2014 The purpose of this study is to identify the role the food bank plays for food security, sustainable livelihoods and building resilience to climate change among smallholder farmers in Uganda. The aim is to investigate how the food bank in Uganda operates in relation to food security and smallholder farmers. Much of the studies on food banks reveal that food banks are merely institutions that offer emergency food supplies to the hungry and are not agencies aiming at food security. These studies have, however, been based on the context of developed countries and no study has been conducted to establish the role of food banks i…
Burden of Comorbidities in Patients with OSAS and COPD-OSAS Overlap Syndrome
2021
Background and Objectives: Obstructive sleep apnea syndrome (OSAS) and chronic obstructive pulmonary disease (COPD) are usually associated with multi-morbidity. The aim of this study was to retrospectively investigate the prevalence of comorbidities in a cohort of patients with OSAS and COPD-OSAS overlap syndrome (OS) patients and to explore differences between these two groups. Materials and Methods: Included were consecutive OS patients and OSAS patients who had been referred to our sleep laboratory, and were matched in terms of sex, age, BMI, and smoking history. Presence of comorbidities was recorded based on their medical history and after clinical and laboratory examination. Results: …
Investigating REPAIRv2 as a Tool to Edit CFTR mRNA with Premature Stop Codons
2020
Cystic fibrosis (CF) is caused by mutations in the gene encoding the transmembrane conductance regulator (CFTR) protein. Some CF patients are compound heterozygous or homozygous for nonsense mutations in the CFTR gene. This implies the presence in the transcript of premature termination codons (PTCs) responsible for a truncated CFTR protein and a more severe form of the disease. Aminoglycoside and PTC124 derivatives have been used for the read-through of PTCs to restore the full-length CFTR protein. However, in a precision medicine framework, the CRISPR/dCas13b-based molecular tool &ldquo
Intrinsic backgrounds from Rn and Kr in the XENON100 experiment
2018
In this paper, we describe the XENON100 data analyses used to assess the target-intrinsic background sources radon ([InlineMediaObject not available: see fulltext.]), thoron ([InlineMediaObject not available: see fulltext.]) and krypton ([InlineMediaObject not available: see fulltext.]). We detail the event selections of high-energy alpha particles and decay-specific delayed coincidences. We derive distributions of the individual radionuclides inside the detector and quantify their abundances during the main three science runs of the experiment over a period of ∼4years, from January 2010 to January 2014. We compare our results to external measurements of radon emanation and krypton concentr…
Reslizumab (RES) in patients (pts) with inadequately controlled asthma and elevated blood eosinophils (EOS): Analysis of two phase 3, placebo-control…
2016
Background: RES reduced exacerbation frequency and improved lung function and asthma control in pts with inadequately controlled asthma and elevated blood EOS in two placebo (PBO)-controlled, phase 3 studies (Castro et al. Lancet Resp Med 2015). Aims/objectives: To determine the efficacy of RES in the subset of pts in these studies meeting the definition of ATS/ERS-defined inadequately controlled asthma. Methods: This was a post-hoc analysis of pooled data from two replicate, 52-week, PBO-controlled studies of RES (3mg/kg IV Q4W) in pts with inadequately controlled asthma and blood EOS ≥400/µL who were using medium-to-high dose inhaled corticosteroids; primary results have been reported. As…
Awake tracheotomy in a patient with stridor and dyspnoea caused by a sizeable malignant thyroid tumor: a case report and short review of the literatu…
2017
Key Clinical Message Individual airway management is mandatory in patients with large goiters undergoing thyroid surgery. Preoperative endoscopic airway evaluation and imaging studies can support clinical decision making. Awake tracheotomy can be an effective and reasonable airway management strategy in such patients.
Sildenafil inhibits the proliferation of cultured human endothelial cells.
2013
The proliferation of endothelial cells plays a crucial role in the development of intraplaque angiogenesis (IPA). IPA is a major source of intraplaque hemorrhage and therefore contributes to the destabilization of atherosclerotic plaques. Therefore, the aim of the present study was to examine, whether sildenafil inhibits endothelial cell growth. The proliferation of human endothelial cells derived from umbilical cord veins (HUVEC) was examined on DNA level by measurements of (3H)-thymidine incorporation. Cell viability was analyzed using trypan blue staining. The proliferation of cultured human endothelial cells was significantly decreased by 1 μmol/l (-48.4%) and 10 μmol/l (-89.6%) sildena…
Novel Perspectives in the Detection of Oral and Nasal Oxidative Stress and Inflammation in Pediatric United Airway Diseases
2010
United airway disease (UAD) concept proposed that asthma and rhinitis are both different clinical manifestation of a single inflammatory process. The aim of this study is to assess in upper and lower airways the level of inflammation and oxidative stress and to investigate the relationship between biomarkers in persistent allergic rhinitis (PER) and in concomitant asthma with PER. By a crosssectional study we measured oral and nasal (FENO) and oral and nasal EBC 8-isoprostane, LTB4 and PGE2 in children with PER (n=14) and with PER and concomitant intermittent asthma (IA; n=25), mild persistent asthma (mA; n=28), moderate persistent asthma (MA; n=13) and in Healthy Controls (HCs; n=13). Oral…
Genetic and Environmental Effects on Telomere Length and Lung Function : A Twin Study
2017
Background The purpose of the study was to estimate the heritability of leukocyte telomere length (LTL) and lung function and to examine whether LTL and lung function share genetic or environmental effects in common. Methods 386 monozygotic and dizygotic Finnish twin sisters (age 68.4±3.4 years) were included. Relative LTL was determined from peripheral blood DNA by qPCR. Lung function measures of FEV1, FVC, FEV1/FVC, and PEF were derived from spirometry. Genetic modeling was performed with MPlus statistical software. Results Univariate analysis revealed that in LTL, 62% (95% confidence interval 50–72) of the variance was explained by additive genetic and 38% (28–50) by unique environmental…
Using the Trace Element Contents in Bronchoalveolar Lavages to Probe the Human Exposure to Inhaled Particulates
2013
Explosive volcanic eruptions eject large volumes of high surface area, metal-rich dust and ash into the atmosphere. In areas near major volcanic eruptions, humans often interact with these materials and may bioaccumulate heavy and toxic metals. To evaluate these interactions, we examine bronchoalveolar lavage samples (BAL) collected from people exposed to the paroxysmal 2001 Etna eruption. BAL samples reveal a strong enrichment of many toxic heavy metals and the capacity for trace elements released from inhaled particles to induce crystallisation of phosphatic microcryst biominerals in intraaveolar spaces. BAL rare earth element (REE) concentration patterns normalised to shale reveal a ‘V-s…