Search results for "resting"
showing 10 items of 141 documents
Mutual Information Analysis of Brain-Body Interactions during different Levels of Mental stress
2019
In this work, we analyze brain-heart interactions during different mental states computing mutual information (MI) between the dynamic activity of different physiological systems. In 18 healthy subjects monitored in a relaxed resting state and during a mental arithmetic and a serious game task, multichannel EEG, one lead ECG, respiration and blood volume pulse were collected via wireless non-invasive biosensors. From these signals, synchronous 300-second time series were extracted measuring brain activity via the δ, θ, α, and β EEG power, and activity of the body district via the ECG R-R interval η, the respiratory amplitude ϱ and the pulse arrival time π. MI was computed using a linear est…
The new iodoacetamidobenzofuran derivative TR120 decreases STAT5 expression and induces antitumor effects in imatinib-sensitive and imatinib-resistan…
2013
The identification of novel compounds modulating the expression/activity of molecular targets downstream to BCR-ABL could be a new approach in the treatment of chronic myeloid leukemias (CMLs) resistant to imatinib or other BCR-ABL-targeted molecules. Recently, we synthesized a new class of substituted 2-(3,4,5-trimethoxybenzoyl)-2-N,N-dimethylamino-benzo[b]furans, and among these 3-iodoacetylamino-6-methoxybenzofuran-2-yl(3,5-trimethoxyphenyl)methanone (TR120) showed marked cytotoxic activity in BCR-ABL-expressing cells. Interestingly, TR120 was more potent than imatinib in cell growth inhibition and apoptosis induction in both BCR-ABL-expressing K562 and KCL22 cells. Moreover, it showed a…
Galangin increases the cytotoxic activity of imatinib mesylate in imatinib-sensitive and imatinib-resistant Bcr-Abl expressing leukemia cells
2008
Resistance to imatinib mesylate is an emergent problem in the treatment of Bcr-Abl expressing myelogenous leukemias and additional therapeutic strategies are required. We observed that galangin, a non-toxic, naturally occurring flavonoid was effective as anti-proliferative, and apoptotic agent in Bcr-Abl expressing K562 and KCL22 cells and in imatinib mesylate resistant K562-R and KCL22-R cells. Galangin induced an arrest of cells in G0–G1phase of cell cycle and a decrease in pRb, cdk4, cdk1, cycline B levels; moreover, it was able to induce a monocytic differentiation of leukemic Bcr-Abl+ cells. Of note, galangin caused a decrease in Bcl-2 levels and markedly increased the apoptotic activi…
Regional Cerebral Blood Flow in Cases of Brain Tumor
1969
The present series consists of 21 patients with brain tumors: 12 malignant gliomas, 4 oligo- dendro gliomas, 3 meningeomas and 2 metastases, studied by the133Xe-gamma-clearance rCBF method. In 16 patients at least 3 determinations of rCBF were performed: a) in the resting state, R; b) during hyperventilation, HV, and c) during hypertension, HT. Of the remaining 5 patients, 1 was studied only during R, while the other 4 were submitted either to HV or to HT additionally to the R study. The average age of this series of patients was 47 years, the youngest being 19 and the oldest 64. rCBF studies had to be performed under general anesthesia (N2O + O2, Engstrom respirator) in 5 instances in whic…
Dihydrocucurbitacin B Inhibits Delayed Type Hypersensitivity Reactions by Suppressing Lymphocyte Proliferation
2007
We have studied the effects of dihydrocucurbitacin B, a triterpene isolated from Cayaponia tayuya roots, on different models of delayed type hypersensitivity (DTH) in mice, as well as on T-lymphocyte proliferation and the mediators involved. In experiments with mice, dihydrocucurbitacin B inhibited the inflammatory reactions induced by oxazolone, dinitrofluorobenzene, and sheep red blood cells, reducing both the edema and cell infiltration. Moreover, the analysis of inflamed tissues showed that dihydrocucurbitacin B reduced the presence of the most relevant cytokines implicated in these processes, including interleukin-1 beta, interleukin-4, and tumor necrosis factor-alpha. Dihydrocucurbita…
Effect of Vestibular Rehabilitation on Spontaneous Brain Activity in Patients With Vestibular Migraine: A Resting-State Functional Magnetic Resonance…
2019
Previous studies have shown that vestibular migraine (VM) is a cerebral disease with recurrent vertigo. Vestibular rehabilitation (VR) is an effective type of physical therapy for minimizing vestibular symptoms, as it improves vestibular compensation in patients with VM. Currently, the cerebral regions that are associated with the pathogenesis of VM are largely unknown. To further understand the underlying mechanisms of VM, we performed resting-state functional magnetic resonance imaging (fMRI) before and after 1 month of VR in 14 patients with VM. The Dizziness Handicap Inventory (DHI), the 36-Item Short-Form Health Survey (SF-36), the Hamilton Depression Scale (HAMD) and the Hamilton Anxi…
Cortical and Cerebellar Oscillatory Responses to Postural Instability in Parkinson's Disease
2021
Introduction: Posture and balance dysfunctions critically impair activities of daily living of patients with progressing Parkinson's disease (PD). However, the neural mechanisms underlying postural instability in PD are poorly understood, and specific therapies are lacking. Previous electrophysiological studies have shown distinct cortical oscillations with a significant contribution of the cerebellum during postural control tasks in healthy individuals.Methods: We investigated cortical and mid-cerebellar oscillatory activity via electroencephalography (EEG) during a postural control task in 10 PD patients with postural instability (PDPI+), 11 PD patients without postural instability (PDPI–…
Trait impulsivity associated with altered resting-state functional connectivity within the somatomotor network
2020
Knowledge of brain mechanisms underlying self-regulation can provide valuable insights into how people regulate their thoughts, behaviors, and emotional states, and what happens when such regulation fails. Self-regulation is supported by coordinated interactions of brain systems. Hence, behavioral dysregulation, and its expression as impulsivity, can be usefully characterized using functional connectivity methodologies applied to resting brain networks. The current study tested whether individual differences in trait impulsivity are reflected in the functional architecture within and between resting-state brain networks. Thirty healthy individuals completed a self-report measure of trait im…
Distinct Patterns of Functional Connectivity During the Comprehension of Natural, Narrative Speech.
2020
Recent continuous task studies, such as narrative speech comprehension, show that fluctuations in brain functional connectivity (FC) are altered and enhanced compared to the resting state. Here, we characterized the fluctuations in FC during comprehension of speech and time-reversed speech conditions. The correlations of Hilbert envelope of source-level EEG data were used to quantify FC between spatially separate brain regions. A symmetric multivariate leakage correction was applied to address the signal leakage issue before calculating FC. The dynamic FC was estimated based on a sliding time window. Then, principal component analysis (PCA) was performed on individually concatenated and te…
Minimally Invasive Assessment of Mental Stress based on Wearable Wireless Physiological Sensors and Multivariate Biosignal Processing
2019
The development of connected health technologies for the continuous monitoring of the psychophysical state of individuals performing daily life activities requires the aggregation of non-intrusive sensors and the availability of methods and algorithms for extracting the relevant physiological information. The present study proposes an integrated approach for the objective assessment of mental stress which combines wirelessly connected low invasive biosensors with multivariate physiological time series analysis. In a group of 18 healthy subjects monitored in a relaxed resting state and during two experimental conditions inducing mental stress and sustained attention (respectively, mental ari…