Search results for "review."

On research work in information systems: Guidelines, recommendations and examples

2021

The most positive aspect of science is that the participants (researchers, reviewers and editors) control and evaluate their work themselves. Therefore they must be supported in one way or another. Fortunately, guidelines have been developed for different methodologies. However, today the guidelines are not very applicable. The first two sets of guidelines published (both positivist studies) had unusual problems. In this work, we analyze and improve the guidelines generally. Previously, selecting a methodology was the task of every researcher. It now seems that every researcher must also conduct a literature review and write a report. We consider methodology, literature review and writing "…

Toll Like Receptors as Sensors of the Tumor Microbial Dysbiosis: Implications in Cancer Progression

2021

Microbiota is a complex ecosystem of active microorganisms resident in the body of mammals. Although the majority of these microorganisms resides at the distal gastrointestinal tract, high-throughput DNA sequencing technology have made possible to understand that several other tissues of the human body host their own microbiota, even those once considered sterile, such as lung tissue. These bacterial communities have important functions in maintaining a healthy body state and the host immune system has evolved multiple mechanisms by which maintaining a symbiotic relationship with the microbiota. The maintenance of this dialogue allows the induction of protective responses to pathogens and r…

Effect of topical alendronate in periodontal defects: systematic review and meta-analysis

2021

Improving the Effect of Transcranial Alternating Current Stimulation (tACS): A Systematic Review

2021

With the development of electrical stimulation technology, traditional transcranial alternating current stimulation (tACS) technology has been found to have the drawback of not targeting a specific area accurately. Studies have shown that optimizing the number and position of electrodes during electrical stimulation has a very good effect on enhancing brain stimulation accuracy. At present, an increasing number of laboratories have begun to optimize tACS. However, there has been no study summarizing the optimization methods of tACS. Determining whether different optimization methods are effective and the optimization approach could provide information that could guide future tACS research. …

Denying the Truth Does Not Change the Facts: A Systematic Analysis of Pseudoscientific Denial of Complex Regional Pain Syndrome

2021

Purpose Several articles have claimed that complex regional pain syndrome (CRPS) does not exist. Although a minority view, it is important to understand the arguments presented in these articles. We conducted a systematic literature search to evaluate the methodological quality of articles that claim CRPS does not exist. We then examined and refuted the arguments supporting this claim using up-to-date scientific literature on CRPS. Methods A systematic search was conducted in MEDLINE, EMBASE and Cochrane CENTRAL databases. Inclusion criteria for articles were (a) a claim made that CRPS does not exist or that CRPS is not a distinct diagnostic entity and (b) support of these claims with subse…

Working hours – tracking the current and future trends

2021

It is important to track the trends of future working hours, since working hours have strong associations to everyday life and work-life interaction, but also to health. In this paper we aim to track the current and future trends in working hours. We discuss the trends through the key dimensions of working hours: the length, timing, tempo and autonomy. We also consider the role of current trends of spatial changes of work. Changes in working time patterns are fostered by several driving factors: globalization and business restructuring challenging the current work organizations, new information technologies, demographic and climate change and the current and future pandemics. The past and c…

Trends in perceived school stress among adolescentsin five Nordic countries 2002–2014

2019

Abstract Associations between school-related stress and poor health, risk behaviours and low well-being are well documented. The aim of this paper was to estimate trends of perceived school stress experienced by boys and girls of different ages in the Nordic countries, and to describe trends in school stress between the Nordic countries. Nordic data from the Health Behaviour in School-aged Children study (HBSC) between 2002 and 2014 were used. The participants were aged 11–16 years. School stress was measured by a single item; “How pressured do you feel by schoolwork?” The participants answering “some” or “a lot” were categorised as reporting school stress.   Sweden, Norway and Denmark had …

Työnantajayhteistyö ammatillisessa kuntoutuksessa ja tuetussa työllistymisessä. Integroiva kirjallisuuskatsaus

2020

Tässä integroivassa kirjallisuuskatsauksessa selvitettiin, miten ammatillista kuntoutusta ja tuettua työllistymistä koskevassa kansainvälisessä kirjallisuudessa on jäsennetty työnantajien ja työhönvalmennuksen ammattilaisten välistä yhteistyötä ja suhdetta. Keskityimme siihen, millaiset työnantajayhteistyön toimintatavat ja strategiat on nähty toimiviksi ja miten yhteistyösuhdetta rakennetaan ja ylläpidetään. Aineiston muodostivat yksilöityjen hakukriteerien avulla valikoidut 19 tekstiä tieteellisistä aikakauslehdistä. Aineisto analysoitiin temaattisen analyysin periaatteita hyödyntäen. Analyysissa hahmottui neljä teemaa. Keskeisiä yhteistyöhön liittyviä toimintatapoja olivat jalkautuminen …

Targeting the Activin Receptor Signaling to Counteract the Multi-Systemic Complications of Cancer and Its Treatments

2021

Muscle wasting, i.e., cachexia, frequently occurs in cancer and associates with poor prognosis and increased morbidity and mortality. Anticancer treatments have also been shown to contribute to sustainment or exacerbation of cachexia, thus affecting quality of life and overall survival in cancer patients. Pre-clinical studies have shown that blocking activin receptor type 2 (ACVR2) or its ligands and their downstream signaling can preserve muscle mass in rodents bearing experimental cancers, as well as in chemotherapy-treated animals. In tumor-bearing mice, the prevention of skeletal and respiratory muscle wasting was also associated with improved survival. However, the definitive proof tha…

Metabolic Changes in Tumor Microenvironment: How Could They Affect γδ T Cells Functions?

2021

The metabolic changes that occur in tumor microenvironment (TME) can influence not only the biological activity of tumor cells, which become more aggressive and auto sustained, but also the immune response against tumor cells, either producing ineffective responses or polarizing the response toward protumor activity. γδ T cells are a subset of T cells characterized by a plasticity that confers them the ability to differentiate towards different cell subsets according to the microenvironment conditions. On this basis, we here review the more recent studies focused on altered tumor metabolism and γδ T cells, considering their already known antitumor role and the possibility of manipulating th…