Search results for "review."
showing 10 items of 4100 documents
New developments in the management of hepatitis C virus infection: focus on boceprevir
2012
Chronic hepatitis C virus infection is an important public health problem, and the standard treatment (combination of pegylated interferon-α and ribavirin) has an effectiveness rate of only 40%-50%. Novel virus-specific drugs have recently been designed, and multiple compounds are under development. The approval for the clinical use of direct-acting antivirals in 2011 (boceprevir [BOC] and telaprevir, viral NS3 protease inhibitors) has increased recovery rates by up to 70%. Therefore, a highly effective treatment has been envisioned for the first time. This paper focuses on BOC and the implementation of new BOC-based treatment regimes.
Amaya, A., Michelon, C. (eds.) (2020), The faces of virtue in law. Routledge
2022
The book, edited by Amalia Amaya and Claudio Michelon, brings together the most significant voices of the Aretaic theory to operate an interesting reconstruction of new topics in the field of philosophy of law which are typically overlooked by traditional legal theory. This approach allows the exploration of new interpretative lines that may suggest further developments for the theory of virtue. Reading this book could therefore be a valid and interesting tool for all those who study the legal decision-making process from a philosophical perspective, but also for all jurists who deal, in a broader sense, with the legal practice.
The interplay between the host microbiome and pathogenic viral infections
2021
The microorganisms associated with an organism, the microbiome, have a strong and wide impact in their host biology. In particular, the microbiome modulates both the host defense responses and immunity, thus influencing the fate of infections by pathogens. Indeed, this immune modulation and/or interaction with pathogenic viruses can be essential to define the outcome of viral infections. Understanding the interplay between the microbiome and pathogenic viruses opens future venues to fight viral infections and enhance the efficacy of antiviral therapies. An increasing number of researchers are focusing on microbiome-virus interactions, studying diverse combinations of microbial communities, …
Immune responses during COVID-19 infection
2020
International audience; Over the past 16 years, three coronaviruses (CoVs), severe acute respiratory syndrome CoV (SARS-CoV) in 2002, Middle East respiratory syndrome CoV (MERS-CoV) in 2012 and 2015, and SARS-CoV-2 in 2020, have been causing severe and fatal human epidemics. The unpredictability of coronavirus disease-19 (COVID-19) poses a major burden on health care and economic systems across the world. This is caused by the paucity of in-depth knowledge of the risk factors for severe COVID-19, insufficient diagnostic tools for the detection of SARS-CoV-2, as well as the absence of specific and effective drug treatments. While protective humoral and cellular immune responses are usually m…
Why viruses sometimes disperse in groups?
2019
AbstractMany organisms disperse in groups, yet this process is understudied in viruses. Recent work, however, has uncovered different types of collective infectious units, all of which lead to the joint delivery of multiple viral genome copies to target cells, favoring co-infections. Collective spread of viruses can occur through widely different mechanisms, including virion aggregation driven by specific extracellular components, cloaking inside lipid vesicles, encasement in protein matrices, or binding to cell surfaces. Cell-to-cell viral spread, which allows the transmission of individual virions in a confined environment, is yet another mode of clustered virus dissemination. Nevertheles…
Scleral Buckling: A Review of Clinical Aspects and Current Concepts
2021
Scleral buckling represents a valuable treatment option for rhegmatogenous retinal detachment repair. The surgery is based on two main principles: the closure of retinal breaks and the creation of a long-lasting chorioretinal adhesion. Buckles are placed onto the sclera with the purpose of sealing retinal breaks. Cryopexy is usually performed to ensure a long-lasting chorioretinal adhesion. Clinical outcomes of scleral buckling have been shown to be more favorable in phakic eyes with uncomplicated or medium complexity retinal detachment, yielding better anatomical and functional results compared with vitrectomy. Several complications have been described following scleral buckling surgery, s…
Twitter – viestinnän vai vuorovaikutuksen alusta?
2018
Kirja-arvostelu teoksesta: Pekka Isotalus, Jari Jussila & Janne Matikainen, 2018. Twitter viestintänä - ilmiöt ja verkostot, Vastapaino, 296 sivua. nonPeerReviewed
Jermut, korpisoturit ja militaristit suomalaisessa sotakirjallisuudessa
2019

 
 
 Arto Jokinen, Isänmaan miehet: Maskuliinisuus, kansakunta ja väkivalta suomalaisessa sotakirjallisuudessa. Toim. Markku Soikkeli ja Ville Kivimäki. Tampere: Vastapaino 2019, 296 s.
 
 
Alcohol use, aquatic injury, and unintentional drowning : A systematic literature review
2018
Issues Drowning is a global public health issue, and there is a strong association between alcohol and risk of drowning. No previous systematic review known to date has identified factors associated with alcohol use and engagement in aquatic activities resulting in injury or drowning (fatal and non‐fatal). Approach Literature published from inception until 31 January 2017 was reviewed. Included articles were divided into three categories: (i) prevalence and/or risk factors for alcohol‐related fatal and non‐fatal drowning and aquatic injury, (ii) understanding alcohol use and aquatic activities, and (iii) prevention strategies. Methodological quality of studies was assessed using National He…
La organización del trabajo por proyectos: La fábrica de la precariedad laboral
2019
The project-based organization, considered as a radical reorganization of work around one or more simultaneous projects, is nowadays widespread in large companies and public administrations. According to the managerial way of thinking, this system would be virtuous: by giving more autonomy to the employees in the act of production and by developing their skills through mobility and interdisciplinarity of work teams, it would be able to arouse their full commitment. This study confirms in some way how this opinion has been imposed, but at the expense of precarious working conditions, increasing the dedication of employees and silencing any form of criticism. The research is based on a review…