Search results for "rex"
showing 10 items of 701 documents
Nanog Regulates Proliferation During Early Fish Development
2009
Abstract Nanog is involved in controlling pluripotency and differentiation of stem cells in vitro. However, its function in vivo has been studied only in mouse embryos and various reports suggest that Nanog may not be required for the regulation of differentiation. To better understand endogenous Nanog function, more animal models should be introduced to complement the murine model. Here, we have identified the homolog of the mammalian Nanog gene in teleost fish and describe the endogenous expression of Ol-Nanog mRNA and protein during medaka (Oryzias latipes) embryonic development and in the adult gonads. Using medaka fish as a vertebrate model to study Nanog function, we demonstrate that …
Influence of Pharmacokinetic Variations on the Pharmacological Properties of Adriamycin
1972
Whenever it appears impossible to modify the chemical structure of drugs with a high and established therapeutic activity but a low chemotherapeutic index, pharmacological research has to find other ways of improving the chemotherapeutic index. This problem is particularly important in the case of antitumor drugs, thus justifying research into the most suitable choice of dosage and routes of administration, as well as into the pharmacological associations which enable tumor cells to be hit at various stages of the reproductive cycle. Alternatively, the therapeutic index could be improved by the use of antagonistic compounds (like, for example, methotrexate and folinic acid) which act upon t…
Conjunction of Conditional Events and t-Norms
2019
We study the relationship between a notion of conjunction among conditional events, introduced in recent papers, and the notion of Frank t-norm. By examining different cases, in the setting of coherence, we show each time that the conjunction coincides with a suitable Frank t-norm. In particular, the conjunction may coincide with the Product t-norm, the Minimum t-norm, and Lukasiewicz t-norm. We show by a counterexample, that the prevision assessments obtained by Lukasiewicz t-norm may be not coherent. Then, we give some conditions of coherence when using Lukasiewicz t-norm
Uncertain sunset lives: British migrants facing Brexit in Spain
2020
One of the most concerned groups potentially impacted by the approval of Brexit in 2016 is that of the so-called “Brexpats”. This group of people is composed by at least 784,900 British citizens who are living in the European Union (EU), among which those settling in Spain are the most prominent. Spanish Brexpats are the largest British population outside the borders of the UK, except for in the Commonwealth territories. They have some peculiar characteristics, such as an advanced average age compared to other EU destinations; a large number of people living off the radar; geographical concentration within coastal areas; and a certain social isolation. In this context, the succession of new…
An infinite family of counterexamples to a conjecture on positivity
2021
Recently, G. Mason has produced a counterexample of order 128 to a conjecture in conformal field theory and tensor category theory in [Ma]. Here we easily produce an infinite family of counterexamples, the smallest of which has order 72.
Neuropeptides’ Hypothalamic Regulation of Sleep Control in Children Affected by Functional Non-Retentive Fecal Incontinence
2020
Functional non-retentive fecal incontinence (FNRFI) is a common problem in pediatric age. FNRFI is defined as unintended loss of stool in a 4-year-old or older child after organic causes have been excluded. FNRFI tends to affects up to 3% of children older than 4 years, with males being affected more frequently than females. Clinically, children affected by FNRFI have normal intestinal movements and stool consistency. Literature data show that children with fecal incontinence have increased levels of separation anxiety, specific phobias, general anxiety, attention-deficit/hyperactivity disorder (ADHD), and oppositional defiant disorder. In terms of possible relationship between incontinence…
Test of the electric charge conservation law with Borexino detector
2015
International audience; The new limit on the electron lifetime is obtained from data of the Borexino experiment. The expected signal from the e → γν decay mode is a 256 keV photon detected in liquid scintillator. Because of the extremely low radioactive background level in the Borexino detector it was possible to improve the previous measurement by two orders of magnitude.
Serological identification and expression analysis of gastric cancer-associated genes
2002
Serological identification of tumour antigens by recombinant expression cloning has proved to be an effective strategy for the identification of cancer-associated genes having a relevance to cancer aetiology and progression, and for defining possible targets for immunotherapeutic intervention. In the present study we applied this technique to identify immunogenic proteins for gastric cancer that resulted in isolation of 14 distinct serum-reactive antigens. In order to evaluate their role in tumourigenesis and assess the immunogenicity of the identified antigens, we characterised each cDNA clone by DNA sequence analysis, mRNA tissue distribution, comparison of mRNA levels in cancerous and ad…
Finite Alphabet Control of Logistic Networks with Discrete Uncertainty
2014
We consider logistic networks in which the control and disturbance inputs take values in finite sets. We derive a necessary and sufficient condition for the existence of robustly control invariant (hyperbox) sets. We show that a stronger version of this condition is sufficient to guarantee robust global attractivity, and we construct a counterexample demonstrating that it is not necessary. Being constructive, our proofs of sufficiency allow us to extract the corresponding robust control laws and to establish the invariance of certain sets. Finally, we highlight parallels between our results and existing results in the literature, and we conclude our study with two simple illustrative exampl…
GSK3β overexpression induces neuronal death and a depletion of the neurogenic niches in the dentate gyrus
2010
Overexpression of GSK3β in transgenic mice induces learning deficits and some features associated with Alzheimer's disease (AD), including dentate gyrus (DG) atrophy. Here, we assessed whether these mice also recapitulate DG atrophy as well as impaired neurogenesis reported in AD. Ultrastructural analysis revealed that there were fewer and more disorganized neurogenic niches in these animals, coupled with an increase in the proportion of immature neurons. Indeed, the maturation of granule cells is delayed as witnessed by the alterations to the length and patterning of their dendritic trees and to the mossy fiber terminals. Together with an increase in neuronal death, these phenomena lead to…