Search results for "rex"
showing 10 items of 701 documents
Non-small cell lung cancer (NSCLC), EGFR downstream pathway activation and TKI targeted therapies sensitivity: Effect of the plasma membrane-associat…
2017
Adenocarcinoma of Non-Small Cell Lung Cancer (NSCLC) is a severe disease. Patients carrying EGFR mutations may benefit from EGFR targeted therapies (e.g.: gefitinib). Recently, it has been shown that sialidase NEU3 directly interacts and regulates EGFR. In this work, we investigate the effect of sialidase NEU3 overexpression on EGFR pathways activation and EGFR targeted therapies sensitivity, in a series of lung cancer cell lines. NEU3 overexpression, forced after transfection, does not affect NSCLC cell viability. We demonstrate that NEU3 overexpression stimulates the ERK pathway but this activation is completely abolished by gefitinib treatment. The Akt pathway is also hyper-activated upo…
Aging Successfully: The Role of Genetics and Environment in the Era of the Aging-Boom. Potential Therapeutic Implications
2019
Aging is one of the main health-related challenges in the world. The average life expectancy of the global population at birth is increasing up to 72 years, in 2016 and it increases about two years every decade. The healthcare costs in many countries are very high because of the increased number of unhealthy populations, and the consequent increase of severe age-related disabilities [1]. Therefore, the goal of the future should be the achievement of the so-called “health-span” (healthy-life-span), more than the treatment of age-related disease to prevent the collapse of the health system. In order to achieve this objective, it is necessary to identify new targets and biomarkers and to addre…
Poor Physical Performance Predicts Future Onset of Depression in Elderly People: Progetto Veneto Anziani Longitudinal Study.
2016
Abstract Background. Reduced physical performance is predictive of deleterious outcomes in older adults. Data considering objective physical performance and incident depression are sparse. Objective. The objective of this study was to investigate during a 4-year study whether objective physical performance can predict incident depression among older adults who do not have depression at the baseline. Design. This was a longitudinal study. Methods. From 3,099 older people initially enrolled in the Progetto Veneto Anziani study, 970 participants without depression at the baseline were included (mean age = 72.5 years; 54.6% women). Physical performance measures included the Short Physical Perfo…
Epidemiology and risk factors of eating disorders: A two-stage epidemiologic study in a Spanish population aged 12-18 years
2003
Objective The authors studied the prevalence rates of eating disorders (ED) and their risk factors in a Spanish population aged 12–18 years. Method A two-stage epidemiologic study was conducted in the province of Valencia. Educational centers, classrooms, and individuals were selected randomly. The initial sample comprised 544 subjects. During Stage 1, subjects were screened with the 40-item Eating Attitude Test and a sociodemographic questionnaire that evaluates risk factors. During Stage 2, a semistandardized clinical interview was conducted with each participant. A random control group was paired by class, age, and sex. Comorbid psychiatric disorders and partial and subclinical forms wer…
Globalization Is Dead: Long Live the Globalization!?
2018
Globalization was the mainstream paradigm in the last 70 years, long enough to create and explain prosperity and welfare in a connected world. Recently, there are many signs that we are reaching a turning point. From jobs, wages, and unemployment to immigrants and Brexit, all the key debates emphasize that the world is preparing for a new kind of globalization which will be less about countries and multinationals and more about people. There is no doubt that old globalization had winners and losers, but more than ever, the voice of the people who reject globalization was heard in 2016, specifically in the UK and USA. The world will have to deal with new institutions, and technologies and wi…
Trattamento medico della gravidanza ectopica diagnosticata precocemente:nostra esperienza.
2006
Gli autori hanno trattato con il methotrexate (MTX) in un'unica somministrazione seguita da una seconda identica dose dop il 7° giorno, se i livelli ematici di B-hCG non diminuiscono tra il 4° e il 7° giorno di almeno il 15%, un gruppo di 20 pazienti affette da gravidanza ectopica diagnosticata precocemente. In 16 pazienti, pari all'80% dei casi, i livelli ematici iniziali di B-hCG sono >1000 U.I./ml e 2000 e <5000 U.I./ml. L'esame ecografico eseguito per via transvaginale in 18 pazienti (pari al 90% dei casi) ha evidenziato una cavità uterina senza camera gestazionale con reazione deciduale ben rappresentata; in 2 pazienti pari al 10%, una massa annessiale di diametro <3cm. In 15 casi (75%…
Online guided self-help to augment standard treatment for people with anorexia nervosa: feasibility, efficacy and process measures
2021
Background: There is mounting evidence on the effectiveness of guided self-help (GSH) interventions to augment, shorten or replace standard care for eating disorders (EDs). However, only few studies have tested the use of GSH for people with anorexia nervosa (AN). Aims: 1) to conduct a systematic review and meta-analysis of GSH in AN, with a focus on clinical outcomes and feasibility; 2) to evaluate the feasibility, acceptability and efficacy of a novel digital GSH intervention for AN (RecoveryMANTRA) tested in addition to treatment as usual (TAU) in the outpatient setting, 3) to assess predictors of drop-out from the RecoveryMANTRA + TAU condition; 4) to establish the role of working allia…
Chromosomenuntersuchungen aus Lymphocyten und Knochenmark von Psoriasis-Kranken nach Langzeitbehandlung mit Methotrexat
1970
4 Psoriasis-Patienten, 3 davon mit zuruckliegender Arsenexposition, hatten Gesamtmengen zwischen 570 und 2735 mg Methotrexat erhalten. Bei diesen Patienten wurden Chromosomendarstellungen aus dem Knochenmark und aus Lymphocytenkulturen durchgefuhrt. Im Knochenmark (ohne Kultur in vitro) fanden sich keine eindeutigen Aberrationen, wahrend in den Lymphocyten in 2 Fallen gehauft (24%) ein Chromosom regellos fehlte, und bei einem Patienten einzelne Bruche zu finden waren. Soweit aus diesen Beobachtungen in Verbindung mit den Daten der Literatur Schlusse gezogen werden durfen, werden sie bezuglich der Chromosomenmutationen diskutiert.
Hidden oscillations in nonlinear control systems
2011
Abstract The method of harmonic linearization, numerical methods, and the applied bifurcation theory together discover new opportunities for analysis of hidden oscillations of control systems. In the present paper new analytical-numerical algorithm for hidden oscillation localization is discussed. Counterexamples construction to Aizerman's conjecture and Kalman's conjecture on absolute stability of control systems are considered.
Hairy black-holes in shift-symmetric theories
2020
Scalar hair of black holes in theories with a shift symmetry are constrained by the no-hair theorem of Hui and Nicolis, assuming spherical symmetry, time-independence of the scalar field and asymptotic flatness. The most studied counterexample is a linear coupling of the scalar with the Gauss-Bonnet invariant. However, in this case the norm of the shift-symmetry current $J^2$ diverges at the horizon casting doubts on whether the solution is physically sound. We show that this is not an issue since $J^2$ is not a scalar quantity, since $J^\mu$ is not a diff-invariant current in the presence of Gauss-Bonnet. The same theory can be written in Horndeski form with a non-analytic function $G_5 \s…