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showing 10 items of 1985 documents
Pulmonary haemodynamics in obstructive sleep apnoea.
1995
In patients with obstructive sleep apnoea syndrome (OSAS), pulmonary haemodynamics can show both transient perturbations during sleep and permanent alterations. During sleep, repeated fluctuations in pulmonary artery pressure and pulmonary wedge pressure, coincident with apnoeas, can be observed. Calculation of transmural pressure values is preferable to intravascular pressures in OSAS, due to the marked swings in intrathoracic pressure associated with obstructive apnoeas. Pulmonary artery pressure may progressively increase during sleep, particularly in close sequences of highly desaturating apnoeas. Apnoea-induced hypoxia appears as the most important determinant of this pulmonary artery …
Visegrad Euroscepticism: Discursive Nodal Points in Eurosceptic Discourses Surrounding External Actions of the European Union
2018
Increasing support for Eurosceptic parties and movements can be observed in the European Union’s (EU) member states since 2009, when the economic crisis heavily affected the continent. This process has happened also within Central and Eastern European countries, especially in Poland, the Czech Republic, Slovakia and Hungary (collectively referred to as the Visegrad Group countries, or V4 for short). The goal of this paper is an analysis of far-right Eurosceptic politicians and their attitudes towards EU external actions. Using the Thomas Diez concept of discursive nodal points (DNPs) and examining European Parliament (EP) debates, literature about V4 Euroscepticism and media reports, this p…
Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes
2019
Background: Titin is a giant elastic protein that spans the half-sarcomere from Z-disk to M-band. It acts as a molecular spring and mechanosensor and has been linked to striated muscle disease. The pathways that govern titin-dependent cardiac growth and contribute to disease are diverse and difficult to dissect. Methods: To study titin deficiency versus dysfunction, the authors generated and compared striated muscle specific knockouts (KOs) with progressive postnatal loss of the complete titin protein by removing exon 2 (E2-KO) or an M-band truncation that eliminates proper sarcomeric integration, but retains all other functional domains (M-band exon 1/2 [M1/2]-KO). The authors evaluated c…
Rare cardiomyopathies: Diagnostic features
2013
Cardiomyopathies (CM) are an important and heterogeneous group of diseases affecting the myocardium. They can induce mechanical and/or electrical disorders and are due to a variety of causes, they frequently are genetic. However, since their high number and their clinical complexity, the identification is still a challenge. Echocardiography is a very useful tool in the assessment of CM. In this review we aim to define the typical clinical features and to discuss the main diagnostic tool, above all echocardiography that can help physicians in the correct assessment of CM.
A fatal iatrogenic right vertebral injury after transoral odontoidectomy and posterior cervical stabilization for a type II odontoid fracture.
2014
Abstract The authors present a singular case of an iatrogenic right vertebral artery injury, involving a 67 year-old man, who reported a type II odontoid fracture (Anderson and D'Alonzo Classification) and posterior atlantoaxial dislocation following a road traffic accident. A small injury involving the right vertebral artery occurred as a consequence of transoral odontoidectomy and posterior cervical stabilization. It was caused by bone spicules of spinal origin and their presence was confirmed by the histological section of the right vertebral artery at the level of C1–C2. The case confirms how iatrogenic vertebral artery injuries during cervical spine surgery may be potentially lethal, e…
Protection of Social Rights as a Permament Challenge for the European Union
2021
Social rights protection in the European Union has undergone significant development. Currently their protection is regulated by relevant treaty provisions and the Charter of Fundamental Rights (Charter), both of a primary law nature, as well as by the non-binding European Pillar of Social Rights (Pillar). The aim of the paper is the assessment of the social rights protection in the EU, and whether all social rights provided in the CFR have their counterparts in the EPSR, hence whether and in what way the EPSR assists the actual exercise of social rights provided by the CFR. Comparing the content of the above-mentioned legal instruments makes it possible to answer the question whether all s…
Geometric Considerations in Modeling Oxygen Transport Processes in Tissue
1973
Numerical solution of partial differential equations describing transport processes in capillaries and tissue is used for calculation of oxygen transport to brain tissue. Calculation is based on a three-dimensional network model which covers inhomogeneities in capillary blood flow in a relation of 27:1, This study was performed in order to obtain information about the influence of the main physiological parameters on oxygen tension frequency distribution pattern. Following results were obtained: a)Increase (or decrease) of the oxygen consumption rate in tissue to about twice (or half) of the normal case for cerebral grey matter causes an extreme left (or right) shift of the oxygen tension f…
Diritti dei bambini, diritti delle famiglie. Promuovere e formare le “capacità” genitoriali
2020
The paper focuses on the reasons for the link between children's rights and family rights, in order to highlight that parenting educational competences are challenging risk factor in contexts of poverty and always decisive factor for the actual promotion of the rights of children and adolescents. More precisely, firstly the passages of of the Convention in which the necessity of the family is argued as primary context of children's rights. Secondly, it will be problematized the very idea of children's rights in the light of the "capability approach". On this basis, it will be asked whether, from a pedagogical point of view, the family can, as a whole, be the holder of a right to education…
Children’s rights system in the Republic of Latvia in compliance with international law regarding out-of-family care system
2020
Children rights have been defined in international and domestic legal systems. Despite the ongoing development of children’s rights, it is still a relatively new legal subset of human rights. So far, under the United Nation Convention on the Rights of the Child, there has been the establishment of international and regional legal acts concerning the rights of the child. As a party to different international and regional legal acts, the Republic of Latvia has to undertake obligations to respect and ensure children’s rights in its jurisdiction. However, the necessity to examine international law before domestic legal acts of the Republic of Latvia is to allege full comprehension of a sense of…
Diritti per l’educazione. Contesti e orientamenti pedagogici
2020
The book focuses on the Convention on the Right of child as the result of a slow historical, cultural and in particular pedagogical path of progressive discovery of the specific dignity of childhood and adolescence. It is argue that, even if nowadays, more than thirty years after the drafting of the Convention, the attention to the intrinsic dignity of boys and girls, may seem indisputable and obvious, however such an attention is an achievement for a small part of the world and, also woth regard to the so-called advanced society, one might wonder to what extent and in what contexts, the twentieth century was the century of children and what is really, in the century we are living, the care…