Search results for "risk factor"
showing 10 items of 4321 documents
Epidemiology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis: Implications for Liver Transplantation.
2018
Nonalcoholic fatty liver disease (NAFLD) affects 25% of the global adult population with a range of 13.5% in Africa and 31.8% in the Middle East. Nonalcoholic fatty liver disease is closely associated with a constellation of metabolic comorbidities which include: obesity, type 2 diabetes mellitus, hypertension, and hypercholesteremia. In fact, the increasing number of metabolic comorbidities not only increases the prevalence of NAFLD but also places patients at higher risk for progressive liver disease. As such, NAFLD is presently among the top etiologies for hepatocellular carcinoma and an indication for liver transplantation (LT) in the United States. Therefore, the following recommendati…
High level of plasma estradiol as a new predictor of ischemic arterial disease in older postmenopausal women: the three-city cohort study.
2012
Background Despite evidence that estrogens may be involved in atherothrombosis, the role of endogenous sex steroid hormones in ischemic arterial disease among postmenopausal women remains uncertain. Methods and Results In the Three‐City prospective cohort study of subjects (n=9294) >65 years of age, we investigated the association of total 17β‐estradiol, bioavailable 17β‐estradiol, and total testosterone with the 4‐year incidence of ischemic arterial disease among postmenopausal women who did not use any hormone therapy. We designed a case–cohort study including a random sample of 537 subjects and 106 incident cases of first cardiovascular events. Weighted Cox proportional‐hazards model…
ADHD and DAT1: Further evidence of paternal over-transmission of risk alleles and haplotype
2010
Contains fulltext : 87259.pdf (Publisher’s version ) (Closed access) We [Hawi et al. (2005); Am J Hum Genet 77:958-965] reported paternal over-transmission of risk alleles in some ADHD-associated genes. This was particularly clear in the case of the DAT1 3'-UTR VNTR. In the current investigation, we analyzed three new sample comprising of 1,248 ADHD nuclear families to examine the allelic over-transmission of DAT1 in ADHD. The IMAGE sample, the largest of the three-replication samples, provides strong support for a parent of origin effect for allele 6 and the 10 repeat allele (intron 8 and 3'-UTR VNTR, respectively) of DAT1. In addition, a similar pattern of over-transmission of paternal ri…
Olive oil intake and cancer risk: A systematic review and meta-analysis
2022
Background Research evidence has established the beneficial effects of diet in cancer prevention; various epidemiological studies have suggested that olive oil component could play a role in decreasing cancer risk. This systematic review and meta-analysis aims to investigate the association between olive oil consumption, cancer risk and prognosis. Methods A systematic search was conducted in PubMed, EMBASE and Google Scholar databases (end-of-search: May 10, 2020). Pooled relative risk (RR) and 95% confidence intervals (95% CIs) were estimated with random-effects (DerSimonian-Laird) models. Subgroup analyses, sensitivity analyses and meta-regression analysis were also performed. Results 45…
Globālo kosmētikas franšīzes devēju bankrota iemesli.
2018
Maģistra darbs “Globālo kosmētikas franšīzes devēju bankrota iemesli” veltīts starptautiski atpazīstamu franšīzes devēju bankrotu izvērtēšanai, kā arī, ietver risku izvērtējumu, kas jāņem vērā uzņēmumiem - franšīzes devējiem, izejot starptautiskajos tirgos, kuru neizvērtēšana var novest pie uzņēmuma bankrota. Maģistra darba tēma - globālo kosmētikas franšīzes devēju bankrots, šobrīd ir ļoti aktuāla, jo 2016.gada oktobrī Latviju pāršalca ziņa, ka viens no jomas spēcīgākajiem uzņēmumiem „Attirance” bankrotēja. Tajā pašā laika periodā masu mēdijos izskanēja ziņas, ka bankrota risks pastāv arī attiecībā uz vairākiem citiem jomas uzņēmumiem, kas ir globāli kosmētikas franšīzes devēji. Darbs ietv…
Psihosociālo risku faktoru izvērtējums un tā pilnveides iespējas SIA “Stoller“
2017
Bakalaura darba autors: Gints Zariņš. Autora bakalaura darba ”Psihosociālo risku faktoru izvērtējums un tā pilnveides iespējas SIA “Stoller“ mērķis ir noteikt iespējamo psihosociālo risku ietekmi uz SIA "Stoller" nodarbinātiem un atkarībā no iegūtajiem rezultātiem, izstrādāt iespējamo preventīvo programmu. Bakalaura darba aktualitāte – darbiniekiem ikdienā ir jāsastopas ar dažādiem darba vides riskiem, t.sk., psihosociāliem, jo kā zināms, tad stress ir organisma emocionālā reakcija uz dažādiem nelabvēlīgiem ārējiem vai iekšējiem faktoriem un mūsdienās darbinieki arvien vairāk laika pavada darbavietās un līdz ar to darba devēja nodrošinātie apstākļi ietekmē gan fiziski, gan arī emocionāli. I…
El consum recreatiu d'esteroides anabolitzants entre els joves valencians
2012
The present study tries to measure the phenomenon of recreational consumption of anabolic steroids amongst youngsters from the city of Valencia by means of the application of qualitative methodology conducted through interviews. The sample was composed by nineteen young men aged between 21 and 34 years, that were selected from fitness centers using the snowball sampling technique. Individuals under use and abuse of anabolic steroids present patterns of consumption similar to other substances of abuse: low risk perception, repeated use and dose increase, as well as the lack of information among them. Therefore, after transcending the sports field, the consumption of anabolic steroids should …
There is more to predicting vascular disease than just established risk factors.
2011
Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies
2007
Endothelial cells control vascular homeostasis by generating paracrine factors that regulate vascular tone, inhibit platelet function, prevent adhesion of leukocytes, and limit proliferation of vascular smooth muscle. The dominant factor responsible for many of those effects is endothelium-derived nitric oxide (NO). Endothelial dysfunction characterized by enhanced inactivation or reduced synthesis of NO, alone or in combination, is seen in conjunction with risk factors for cardiovascular disease. Endothelial dysfunction can promote vasospasm, thrombosis, vascular inflammation, and proliferation of the intima. Vascular oxidative stress and increased production of reactive oxygen species con…
Sprint Acceleration Mechanics in Fatigue Conditions: Compensatory Role of Gluteal Muscles in Horizontal Force Production and Potential Protection of …
2018
Aim: Hamstring muscle injury is the main injury related to sports requiring sprint acceleration. In addition, hamstring muscles have been reported to play a role in horizontal force production during sprint acceleration performance. The aim of the present study was to analyze (i) the determinants of horizontal force production and (ii) the role of hip extensors, and hamstring muscles in particular, for horizontal force production during repeated sprint-induced fatigue conditions. Method: In this experimental laboratory setting study including 14 sprint-trained male athletes, we analyzed (i) the changes in sprint mechanics, peak torque of the knee and hip extensors and flexors, muscle activi…