Search results for "rites"

The GRIP1/14-3-3 Pathway Coordinates Cargo Trafficking and Dendrite Development

2014

SummaryRegulation of cargo transport via adaptor molecules is essential for neuronal development. However, the role of PDZ scaffolding proteins as adaptors in neuronal cargo trafficking is still poorly understood. Here, we show by genetic deletion in mice that the multi-PDZ domain scaffolding protein glutamate receptor interacting protein 1 (GRIP1) is required for dendrite development. We identify an interaction between GRIP1 and 14-3-3 proteins that is essential for the function of GRIP1 as an adaptor protein in dendritic cargo transport. Mechanistically, 14-3-3 binds to the kinesin-1 binding region in GRIP1 in a phospho-dependent manner and detaches GRIP1 from the kinesin-1 motor protein …

Isolation of the silicatein-α interactor silintaphin-2 by a novel solid-phase pull-down assay.

2011

The skeleton of siliceous sponges consists of amorphous biogenous silica (biosilica). Biosilica formation is driven enzymatically by means of silicatein(s). During this unique process of enzymatic polycondensation, skeletal elements (spicules) that enfold a central proteinaceous structure (axial filament), mainly comprising silicatein, are formed. However, only the concerted action of silicatein and other proteins can explain the genetically controlled diversity of spicular morphotypes, from simple rods with pointed ends to intricate structures with up to six rays. With the scaffold protein silintaphin-1, a first silicatein interactor that facilitates the formation of the axial filament and…

The role of the silicatein-alpha interactor silintaphin-1 in biomimetic biomineralization.

2008

Biosilicification in sponges is initiated by formation of proteinaceous filaments, predominantly consisting of silicateins. Silicateins enzymatically catalyze condensation of silica nanospheres, resulting in symmetric skeletal elements (spicules). In order to create tailored biosilica structures in biomimetic approaches it is mandatory to elucidate proteins that are fundamental for the assembly of filaments. Silintaphin-1 is a core component of modularized filaments and also part of a spicule-enfolding layer. It bears no resemblance to other proteins, except for the presence of an interaction domain that is fundamental for its function as scaffold/template. In the presence of silicatein sil…

Ciminna, First Stop - 27 Thursday

2016

A description of the stratigraphic setting and tectonic evolution of the Late Neogene Ciminna basin (Northern Sicily)

Eustatic and oceanographic control on sedimentary evolution of middle-late Quaternary shelf margin-to-upper slope deposits on the Egadi Islands offsh…

2016

During the past decades a number of sequence stratigraphy studies illustrated how, during Quaternary, interaction between sea level changes and sediment supply controlled the depositional evolution along continental margins, giving a cyclic signature to the sedimentary infilling. However, as both deposition and erosion are processes ultimately controlled by balance between environmental energy and sedimentary influx, also the oceanographic regime takes part in controlling the sedimentary growth along the continental margin. This is exactly what occurs on physiographic settings as islands offshore areas, where bottom currents can be very energetic. In the western Sicily offshore, southwards …

Evaporites in Sicily: geological and karst features

2012

First report on the sinkhole phenomena in the Sicilian evaporites (Southern Italy)

2009

Geology and petrochemistry of recent (25 ka) silicic volcanism at Pantelleria Island

2007

built a complex sequence of interfingered deposits emitted by closely spaced eruptive vents which are frequently associated with dome-building phases and pantelleritic lavas flows. Field relationships allowed us to recognize eight eruptive units, all lying above the Montagna Grande trachytes. As a whole, petrochemical characteristics of the erupted products indicate an evolutionary trend in which Na-clinopyroxene was the liquidus phase, followed by alkali feldspar. Amphibole and quartz are late-crystallizing, whereas aenigmatite is both early- and late-crystallizing as well. Aenigmatite and Na-clinopyroxene crystallization buffers efficiently the increase of agpaicity, induced by feldspar c…

A Ferrite Tubular Linear Motor (FTLM): Analysis and design

2015

The electromagnetic linear machines have wide applications in the electromagnetic aircraft launch systems [1] and in transportation systems [2]. Additional energy saving and efficiency can be achieved using a linear motor in the refrigeration application [3]. Linear electromagnetic machines are also very suitable for high-speed packaging, manufacturing sectors and precision positioning. There are different linear motor topologies. Tubular permanent-magnets are particularly attractive since they have a high thrust force density and high efficiency, no end windings, and zero net attractive force between stator and armature. There are various tubular motor topologies, in which the armature may…

Note di Abū Naṣr al-Fārābī sulla verità e falsità dell’astrologia

2020

Il presente contributo propone l’introduzione, la traduzione italiana e il commento delle Note sulla verità e falsità dell’astrologia (Nukat fī mā yaṣiḥḥu wa-mā lā yaṣiḥḥu min aḥkām al-nuǧūm) di Abū Naṣr al-Fārābī (m. 950). Tale scritto non è stato trasmesso direttamente dal suo autore né ci è giunto nella sua redazione definitiva, bensì in forma di appunti ricopiati da un grammatico di nome Abū Isḥāq al-Baġdādī. In trenta brevi capitoli al-Fārābī spiega ciò che è accessibile e ciò che è inaccessibile alle predizioni astrologiche e quali aspetti di tale scienza sia opportuno accogliere o respingere.