Search results for "rotu"

Groin and Testicle

2015

Ultrasound examination is the modality of choice for imaging most of the conditions of the groin and scrotal area in the pediatric population. Along with the more commonly known benefits of ultrasound as a fast, less expensive, noninvasive examination without radiation, readily available and reproducible, sonography of the groin and scrotum demonstrates high levels of specificity, sensitivity, and overall diagnostic accuracy. Ultrasound provides excellent anatomic detail and serves as an important and tremendously helpful imaging modality in all types of pediatric scrotal pathology.

Inhibition of TSH/IGF-1 Receptor Crosstalk by Teprotumumab as a Treatment Modality of Thyroid Eye Disease

2021

Abstract Context We previously presented evidence that TSH receptor (TSHR)-stimulating autoantibodies (TSAbs) bind to and activate TSHRs but do not bind to IGF1 receptors (IGF1Rs). Nevertheless, we showed that IGF1Rs were involved in thyroid eye disease (TED) pathogenesis because TSAbs activated crosstalk between TSHR and IGF1R. Teprotumumab, originally generated to inhibit IGF1 binding to IGF1R, was recently approved for the treatment of TED (Tepezza). Objective To investigate the role of TSHR/IGF1R crosstalk in teprotumumab treatment of TED. Design We used orbital fibroblasts from patients with TED (TEDOFs) and measured stimulated hyaluronan (HA) secretion as a measure of orbital fibrobla…

Harvinaisista maametalleista ja niiden erotusmenetelmistä

2014

Työn tarkoituksena oli selvittää soveltuvia kemiallisia tekniikoita harvinaisten maametallien erottamiseen sekä luontaisista, että ihmisperäisen teollisuuden lähteistä. Tavoitteena oli saavuttaa hyvä näkemys aiheen historiasta, kehityksestä ja nykytilasta. Harvinaiset maametallit ovat kemiallisesti samankaltainen joukko, johon sisältyvät skandium, yttrium ja lantanoidit. Työssä käydään läpi harvinaisten maametallien keskeinen kemia, käyttö, saatavuus ja maailmanmarkkinoiden asettamat haasteet. Kiinan harvinaisten maametallien tuotanto ja sen aiheuttamat vaikutukset maailmankauppapolitiikkaan ovat merkittäviä, ja työssä korostetaan tällä hetkellä vallitsevaa tilannetta harvinaisten maametall…

‘My skin is hard’ - adult learners’ resistance to racialization and racism

2021

This article analyzes experiences of racialization in stories of adult learners with refugee experience who attend a basic education program at a Finnish community college. Throughout a two-year ethnographic study, several students shared stories and thoughts on racialization and racism with the white researcher on site (the author). This article tells and theorizes their stories to gain a deeper understanding of the workings of everyday racialization and racism in a Finnish educational context. Theoretically, the article draws on a Critical Race Theory (CRT) framework, which recognizes the inherence of racialization and racism in society and underlines the importance and legitimacy of BIPO…

SOME COMPARATIVE REMARKS ON THE TRANSIENT CHANGE IN LACTIC ACID CONTENT IN SEA URCHIN EGGS FOLLOWING FERTILIZATION.

1964

Abstract During the first few minutes following fertilization a transient increase in the concentration of lactic acid occurs in the eggs of Arbacia lixula , whereas no change at all is observed in the eggs of Paracentrotus liuidus . In the eggs of Psammechinus miliaris there is a transient decrease, soon followed by a recovery so that the level of the unfertilized egg is again reached.

Teprotumumab reduces extraocular muscle and orbital fat volume in thyroid eye disease

2020

PurposeThyroid eye disease (TED) is a progressive, debilitating and potentially vision-threatening autoimmune disease. Teprotumumab, a novel human monoclonal antibody, has been shown to reverse the clinical manifestations of TED. Patients receiving teprotumumab have been shown in two multicenter, randomized placebo-controlled trials to have decreased proptosis, diplopia and inflammation after 24 weeks of treatment. This study aims to analyse volumetric and inflammatory changes on orbital imaging prior to and after teprotumumab treatment from one of these trials.DesignRetrospective review.SubjectsSix patients enrolled in the phase III teprotumumab clinical trial (OPTIC, NCT03298867) with act…

Light-dependent CK2-mediated phosphorylation of centrins regulates complex formation with visual G-protein.

2008

AbstractCentrins are Ca2+-binding EF-hand proteins. All four known centrin isoforms are expressed in the ciliary apparatus of photoreceptor cells. Cen1p and Cen2p bind to the visual G-protein transducin in a strictly Ca2+-dependent way, which is thought to regulate light driven movements of transducin between photoreceptor cell compartments. These relatively slow motile processes represent a novel paradigm in light adaptation of photoreceptor cells.Here we validated specific phosphorylation as a novel regulator of centrins in photoreceptors. Centrins were differentially phosphorylated during photoreceptor dark adaptation. Inhibitor treatments revealed protein kinase CK2 as the major protein…

In silico identification of the TRIM gene complement of the sea urchin and computational prediction of Helitron-N2 transposable element in the 5’ non…

2011

Relation between climatic fluctuation and morphological variability in Microtus (Terricola) grafi (Arvicolinae, Rodentia) from Bacho Kiro (Bulgaria, …

2004

Morphological variability within the species Microtus (Terricola) grafi is investigated in relation to the parameters of time and climate. Microtus (Terricola) grafi has been described from the Upper Pleistocene cave of Bacho Kiro (Bulgaria), which has yielded numerous teeth from several levels reflecting climatic fluctuations. The first lower molars are analyzed by 23 biometric variables so as to quantify tooth shape and its variation with time and climate. This morphological analysis reveals a number of shape indexes reflecting whether an individual lived in warm or cold conditions. The most significant result is that individuals living in warm conditions exhibit the more primitive featur…

Phylogeny and biogeography of fossil and extant Microtus (Terricola) (Mammalia, Rodentia) of Sicily and the southern Italian peninsula based on curre…

2011

Abstract The fossil record of the Savi vole, Microtus ( Terricola ) savii , is analyzed in terms of morphological and morphometrical variability of the first lower molar, in order to reconstruct phylogenetic relationships between insular and mainland populations and the dispersal events. The present work gives a contribution to better understand the phylogenetic history of this taxon in Sicily and Southern Italy during the interval Middle Pleistocene – Holocene, in an attempt to reconstruct the relationships between insular and continental voles and to clarify some paleobiogeographical aspects. The morphometrical data have been acquired by traditional measurements of the first lower molar a…