Search results for "rpoS"
showing 10 items of 512 documents
How to Assess the Ecological Status of Highly Humic Lakes? Development of a New Method Based on Benthic Invertebrates
2021
Highly humic lakes are typical for the boreal zone. These unique ecosystems are characterised as relatively undisturbed habitats with brown water, high acidity, low nutrient content and lack of macrophytes. Current lake assessment methods are not appropriate for ecological assessment of highly humic lakes because of their unique properties and differing human pressures acting on these ecosystems. This study proposes a new approach suitable for the ecological status assessment of highly humic lakes impacted by hydrological modifications. Altogether, 52 macroinvertebrate samples from 15 raised bog lakes were used to develop the method. The studied lakes are located in the raised bogs at the c…
Intermittent Aeration in a Hybrid Moving Bed Biofilm Reactor for Carbon and Nutrient Biological Removal
2020
The paper presents an experimental study on a lab scale hybrid moving bed biofilm reactor with intermittent aeration. Specifically, a comparison between two different operating conditions was analyzed: continuous and intermittent aeration. Both continuous and intermittent aeration were monitored and compared in order to get the best operational conditions. The intermittent aeration campaign was sub-divided in three phases with different duration of alternation of aerobic and anoxic times and organic and nitrogen loading rates. The efficiency of N-removal improved by 70% during the intermittent aeration. The best condition was observed with 40 min of aeration and 20 min of no-aeration, an or…
On the Occurrence of Metadiaptomus chevreuxi (Calanoida, Diaptomidae, Paradiaptominae) in the Iberian Peninsula, With Notes on the Ecology and Distri…
2020
Temporary ponds are one of the most peculiar ecosystems in the world, being characterized by an extraordinarily rich crustacean fauna, with a high degree of endemism. Among them, diaptomid copepods are among the most biogeographically interesting taxa. However, the present knowledge on diaptomid distribution is still far from being exhaustive, even in the relatively well-studied western European countries. In this study, we report the first record of the diaptomid calanoid copepod Metadiaptomus chevreuxi for the Iberian Peninsula, where it was collected in five temporary ponds in Andalusia (Spain). The characteristics of the new sites are described, the literature dealing with the European …
Characteristics, Main Impacts, and Stewardship of Natural and Artificial Freshwater Environments: Consequences for Biodiversity Conservation
2020
International audience; In this overview (introductory article to a special issue including 14 papers), we consider all main types of natural and artificial inland freshwater habitas (fwh). For each type, we identify the main biodiversity patterns and ecological features, human impacts on the system and environmental issues, and discuss ways to use this information to improve stewardship. Examples of selected key biodiversity/ecological features (habitat type): narrow endemics, sensitive (groundwater and GDEs); crenobionts, LIHRes (springs); unidirectional flow, nutrient spiraling (streams); naturally turbid, floodplains, large-bodied species (large rivers); depth-variation in benthic commu…
Gauge theory of the long-range proximity effect and spontaneous currents in superconducting heterostructures with strong ferromagnets
2017
We present the generalized quasiclassical theory of the long-range superconducting proximity effect in heterostructures with strong ferromagnets, where the exchange splitting is of the order of Fermi energy. In the ferromagnet the propagation of equal-spin Cooper pairs residing on the spin-split Fermi surfaces is shown to be governed by the spin-dependent Abelian gauge field which results either from the spin-orbital coupling or from the magnetic texture. This additional gauge field enters into the quasiclassical equations in superposition with the usual electromagnetic vector potential and results in the generation of spontaneous superconducting currents and phase shifts in various geometr…
Finding Software Bugs in Embedded Devices
2021
AbstractThe goal of this chapter is to introduce the reader to the domain of bug discovery in embedded systems which are at the core of the Internet of Things. Embedded software has a number of particularities which makes it slightly different to general purpose software. In particular, embedded devices are more exposed to software attacks but have lower defense levels and are often left unattended. At the same time, analyzing their security is more difficult because they are very “opaque”, while the execution of custom and embedded software is often entangled with the hardware and peripherals. These differences have an impact on our ability to find software bugs in such systems. This chapt…
Roles for RpoS in survival of Escherichia coli during protozoan predation and in reduced moisture conditions highlight its importance in soil environ…
2017
The soil is a complex ecosystem where interactions between biotic and abiotic factors determine the survival and fate of microbial inhabitants of the system. Having previously shown that Escherichia coli requires the general stress response regulator, RpoS, to survive long term in soil, it was important to determine what specific conditions in this environment necessitate a functional RpoS. This study investigated the susceptibility of soil-persistent E. coli to predation by the single-celled eukaryotes Acanthamoeba polyphaga and Tetrahymena pyriformis, and the role RpoS plays in resisting this predation. Strain-specific differences were observed in the predation of E. coli strains, with so…
Repurposing of Bromocriptine for Cancer Therapy
2018
Bromocriptine is an ergot alkaloid and dopamine D2 receptor agonist used to treat Parkinson’s disease, acromegaly, hyperprolactinemia, and galactorrhea, and more recently diabetes mellitus. The drug is also active against pituitary hormone-dependent tumors (prolactinomas and growth-hormone producing adenomas). We investigated, whether bromocriptine also inhibits hormone-independent and multidrug-resistant (MDR) tumors. We found that bromocriptine was cytotoxic towards drug-sensitive CCRF-CEM, multidrug-resistant CEM/ADR5000 leukemic cells as well as wild-type or multidrug-resistant ABCB5-transfected HEK293 cell lines, but not sensitive or BCRP-transfected multidrug-resistant MDA-MB-231 brea…
Cancer therapy and treatments during COVID-19 era
2020
The COVID-19 pandemic has put a serious strain on health treatments as well at the economies of many nations. Unfortunately, there is not currently available vaccine for SARS-Cov-2/COVID-19. Various types of patients have delayed treatment or even routine check-ups and we are adapting to a virtual world. In many cases, surgeries are delayed unless they are essential. This is also true with regards to cancer treatments and screening. Interestingly, some existing drugs and nutraceuticals have been screened for their effects on COVID-19. Certain FDA approved drugs, vitamin, natural products and trace minerals may be repurposed to treat or improve the prevention of COVID-19 infections and disea…
Repurposing of plant alkaloids for cancer therapy: Pharmacology and toxicology.
2019
Drug repurposing (or repositioning) is an emerging concept to use old drugs for new treatment indications. Phytochemicals isolated from medicinal plants have been largely neglected in this context, although their pharmacological activities have been well investigated in the past, and they may have considerable potentials for repositioning. A grand number of plant alkaloids inhibit syngeneic or xenograft tumor growth in vivo. Molecular modes of action in cancer cells include induction of cell cycle arrest, intrinsic and extrinsic apoptosis, autophagy, inhibition of angiogenesis and glycolysis, stress and anti-inflammatory responses, regulation of immune functions, cellular differentiation, a…