Search results for "rs1800629"

showing 3 items of 3 documents

Age and Cytokine Gene Variants Modulate the Immunogenicity and Protective Effect of SARS-CoV-2 mRNA-Based Vaccination

2023

The introduction of anti-SARS-CoV-2 vaccines in late 2020 substantially changed the pandemic picture, inducing effective protection in the population. However, individual variability was observed with different levels of cellular response and neutralizing antibodies. We report data on the impact of age, gender, and 16 single nucleotide polymorphisms (SNPs) of cytokine genes on the anti-SARS-CoV-2 IgG titers measured 31 and 105 days after administration of the second dose of BNT162b2 vaccine to 122 healthy subjects from the health care staff of the Palermo University Hospital, Italy. The higher titers at 31 days were measured in the younger subjects and in subjects bearing T-positive genotyp…

PharmacologyTNFA rs1800629anti-SARS-CoV-2 S1/S2 IgGanti-SARS-CoV-2 vaccineSettore MED/07 - Microbiologia E Microbiologia ClinicaImmunologyanti-SARS-CoV-2 vaccine; anti-SARS-CoV-2 S1/S2 IgG; cytokine gene SNPs; <i>IL-1R1 rs2234650</i>; <i>IL-6 rs1800795</i>; <i>IL-4 rs2243250</i>; <i>TNFA rs1800629</i>IL-1R1 rs2234650Infectious DiseasesIL-4 rs2243250Drug DiscoveryIL-6 rs1800795Settore MED/05 - Patologia ClinicaPharmacology (medical)cytokine gene SNPs.
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TGF-&beta;/VEGF-A Genetic Variants Interplay in Genetic Susceptibility to Non-Melanocytic Skin Cancer

2022

Differential genetically determined expression of transforming growth factor-&beta; (TGF-&beta; pathway and of vascular endothelial growth factor-A (VEGF-A) might modulate the molecular &ldquo;milieu&rdquo; involved in the etio-pathogenesis of non-melanoma skin cancer (NMSC). We have evaluated the frequency of some functionally relevant SNPs of TGF-&beta; and VEGF-A genes in 70 NMSC patients and 161 healthy controls, typed for TGF-&beta;1 rs1800471, TGF-&beta;2 rs900, TGF-&beta;R1 rs334348 and rs334349, TGF-&beta;R2 rs4522809 and VEGF-A rs3025039 SNPs. TGF-&beta;R2 rs1800629G allele and related genotypes were found to be associated with a possible protective role against NMSC, whereas VEGF-…

Settore MED/04 - Patologia GeneraleVEGF-A geners1800629<i>TGF-β receptor genes</i>; <i>rs1800629</i>; <i>VEGF-A gene</i>; <i>rs3025039</i>; non melanocytic skin cancer; skin basal cell carcinoma; skin squamous cell carcinoma; genetic susceptibilityTGF-β receptor geneGeneticsskin basal cell carcinomaskin squamous cell carcinomaSettore MED/05 - Patologia Clinicanon melanocytic skin cancerGenetics (clinical)genetic susceptibilityrs3025039Genes; Volume 13; Issue 7; Pages: 1235
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Cytokine Polymorphism in Takotsubo Cardiomyopathy

2014

IMIN11. Cytokine Polymorphism in Takotsubo Cardiomyopathy P. Di Gangi1, L. Scola1, S. Giambanco1, M. Bova1, G. Santini1, L. Vaccarino1, C. R. Balistreri1, D. Lio1, P. Assennato1, S. Novo1, G. Novo1 1University of Palermo, Palermo, Italy Background: Takotsubo (TT) cardiomyopathy is characterised by an acute left ventricular dysfunction triggered by emotional or physical stresses. Clinically, the syndrome is characterised by acute symptoms mimicking acute infarction without relevant electrocardiographic and biochemical markers of myocardial damage changes. Stressful events inducing an excess catecholamine release and myocardial β-adrenergic receptors (β-AR) seem to play a major role in TT. Ac…

Takotsubo (TT) cardiomyopathy ADRB-1 (rs1801253) IL–1A (rs1800587) IL-1B (rs16944) (rs1143634) IL-6 (rs1800795) TNF-α(rs1800629) TGF- β(rs1800471) IL-10 (rs1800872) (rs1800871) (rs1800896) MAL (rs8177374) and TLR-4 polymorphisms
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