Search results for "sGC"

showing 6 items of 6 documents

Role of CB2 receptors and cGMP pathway on the cannabinoid-dependent antiepileptic effects in an in vivo model of partial epilepsy.

2014

This study aimed at providing an insight on the possible role of cannabi-noid (CB) type 2 receptors (CB2R) and cGMP pathway in the antiepileptic activity ofWIN 55,212-2, (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylmethyl) pyrrolo[1,2,3-de]-1,4-benzoxazin-6-Yl]-1-naphthalenylmethanone, a non-selective CB agonist, in the maximal dentate activation (MDA) model of partial epilepsy in adult male rats. We evaluated the activity of a CB2 antagonist/inverse agonist AM630, [6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone or 6-iodopravadoline, alone or in co-administration with WIN 55,212-2. Also, in the MDA model it was investigated the co-treatment of WIN55,212…

AgonistMaleIndolessGCmedicine.drug_classmedicine.medical_treatmentMorpholinesPharmacologyNaphthalenesSettore BIO/09 - FisiologiaHippocampusNitric oxideReceptor Cannabinoid CB2chemistry.chemical_compoundHippocampumedicineCannabinoid receptor type 2Inverse agonistAnimalsRats WistarReceptorCannabinoidCannabinoid Receptor AntagonistsCyclic GMPCannabinoid Receptor AgonistsElectrophysiology.ChemistryAntagonistElectric StimulationBenzoxazinesDisease Models AnimalNeurologyGuanylate CyclaseAnticonvulsantsNeurology (clinical)CannabinoidEpilepsies PartialSoluble guanylyl cyclaseTemporal Lobe Epilepsy AM630Epilepsy research
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The distribution of phthalate esters in indoor dust of Palermo (Italy).

2013

In this work, phthalic acid esters (PAEs): dimethyl phthalate (DMP), diethyl phthalate (DEP), di-n-butyl phthalate, benzyl butyl phthalate, bis(2-ethylhexyl) phthalate, and di-n-octyl phthalate in indoor dust (used as passive sampler) were investigated. The settled dust samples were collected from thirteen indoor environments from Palermo city. A fast and simple method using Soxhlet and GC–MS analysis has been optimized to identify and quantify the phthalates. Total phthalates concentrations in indoor dusts ranged from 269 to 4,831 mg/kg d.w. (d.w. = dry weight). The data show a linear correlation between total PAEs concentration and a single compound content, with the exclusion of the two …

Environmental EngineeringPhthalic AcidsIndoor dust Phthalates esters GC–MS Contaminants ItalyDiethyl phthalateGas Chromatography-Mass SpectrometrySettore CHIM/12 - Chimica Dell'Ambiente E Dei Beni Culturalichemistry.chemical_compoundGeochemistry and PetrologyEnvironmental Science(all)Benzyl butyl phthalateContaminantsEnvironmental ChemistryGC–MSSettore CHIM/01 - Chimica AnaliticaPhthalates estersCitiesGeneral Environmental ScienceWater Science and TechnologyOriginal PaperAir PollutantsChemistryPhthalateDustEstersGeneral MedicineContaminationPhthalic acidIndoor dustItalyEnvironmental chemistryAir Pollution IndoorLinear correlationGas chromatography–mass spectrometryDimethyl phthalateIndoor dustPhthalates estersGC–MSContaminantsItalyEnvironmental Monitoring
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Conceptual design of the International Axion Observatory (IAXO)

2014

The International Axion Observatory (IAXO) will be a forth generation axion helioscope. As its primary physics goal, IAXO will look for axions or axion-like particles (ALPs) originating in the Sun via the Primakoff conversion of the solar plasma photons. In terms of signal-to-noise ratio, IAXO will be about 4-5 orders of magnitude more sensitive than CAST, currently the most powerful axion helioscope, reaching sensitivity to axion-photon couplings down to a few $\times 10^{-12}$ GeV$^{-1}$ and thus probing a large fraction of the currently unexplored axion and ALP parameter space. IAXO will also be sensitive to solar axions produced by mechanisms mediated by the axion-electron coupling $g_{…

MICROPICPhysics - Instrumentation and DetectorsPhotonaxionsParameter space7. Clean energyHigh Energy Physics - ExperimentDark Matter detectors (WIMPs axions etc.)High Energy Physics - Experiment (hep-ex)Observatoryetc.)Micropattern gaseous detectors (MSGC GEM THGEM RETHGEM MHSP MICROPIC MICROMEGAS InGrid etc)Detectors and Experimental TechniquesInstrumentationMathematical PhysicsPhysicsGEMsolar [axion]Dark Matter Detectors (Wimps Axions etc.)MicroMegas detectorX-ray detectorsInstrumentation and Detectors (physics.ins-det)Dark Matter detectors (WIMPs axions etc.); Large detector systems for particle and astroparticle physics; Micropattern gaseous detectors (MSGC GEM THGEM RETHGEM MHSP MICROPIC MICROMEGAS InGrid etc); X-ray detectors; Instrumentation; Mathematical PhysicssolarobservatoryMICROMEGASMHSPaxion-like particlesproposed experimentaxions ; dark matter detectors ; x-ray detectors ; Micropattern gaseous detectors ; large detector systems for particle and astroparticle physicsMicromegasX-ray detectorParticle physicsoptics [X-ray]FOS: Physical sciencesSuperconducting magnetMicropattern gaseous detectors (MSGCddc:610Axionactivity reportDark Matter detectors (WIMPssuperconductivity [magnet]etc)HelioscopeLarge detector systems for particle and astroparticle physicssensitivityInGridRETHGEMOrders of magnitude (time)axionLarge detector systems for particle and astroparticle physicTHGEMMicropattern Gaseous Detectors (MSGC Gem THGEM Rethgem MHSP Micropic Micromegas In Grid; etc)
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The SGLT2 inhibitor empagliflozin improves the primary diabetic complications in ZDF rats

2017

Hyperglycemia associated with inflammation and oxidative stress is a major cause of vascular dysfunction and cardiovascular disease in diabetes. Recent data reports that a selective sodium-glucose co-transporter 2 inhibitor (SGLT2i), empagliflozin (Jardiance®), ameliorates glucotoxicity via excretion of excess glucose in urine (glucosuria) and significantly improves cardiovascular mortality in type 2 diabetes mellitus (T2DM). The overarching hypothesis is that hyperglycemia and glucotoxicity are upstream of all other complications seen in diabetes. The aim of this study was to investigate effects of empagliflozin on glucotoxicity, β-cell function, inflammation, oxidative stress and endothel…

Male0301 basic medicineendocrine system diseasesDiabetic CardiomyopathiesFPS-ZM1 RAGE inhibitorClinical BiochemistryAorta ThoracicRAGE receptor for AGEICAM-1 intercellular adhesion molecule-1ECL enhanced chemiluminescence030204 cardiovascular system & hematologyDPP-4 dipeptidyl peptidase-4medicine.disease_causeTNF-α tumor necrosis factor-αBiochemistryeNOS endothelial •NO synthase (type 3)0302 clinical medicineGlucosidesecSOD extracellular superoxide dismutaseInsulin-Secreting CellsCCL-2 see MCP-1HyperlipidemiaHyperinsulinemiaGTN glyceryl trinitrate (nitroglycerin)IFN-γ interferon-γDHE dihydroethidineEndothelial dysfunctionEndothelial dysfunctionIL-6 interleukin-6lcsh:QH301-705.5HO-1 heme oxygenase-1lcsh:R5-920ICAM-1NG normoglycemiaDiabetesNox catalytic subunit of NADPH oxidaseSGLT2 inhibitorβ-cell contentL-012 8-amino-5-chloro-7-phenylpyrido[34-d]pyridazine-14-(2H3H)dione sodium saltChIP chromatin immunoprecipitationC-Reactive ProteinCRP C-reactive proteinAGE advanced glycation end productsHbA1c glycohemoglobinlcsh:Medicine (General)Research PaperZucker diabetic fatty ratsmedicine.medical_specialtyDMSO dimethylsulfoxideMCP-1 monocyte-chemoattractant-protein-1qRT-PCR quantitative reverse transcription polymerase chain reactionZDF Zucker diabetic fatty (rat)Low-grade inflammation03 medical and health sciencesROS reactive oxygen speciesSodium-Glucose Transporter 2Physiology (medical)Internal medicineDiabetes mellitusPKC protein kinase CEmpagliflozinmedicineAnimalsHypoglycemic AgentsBenzhydryl CompoundsCOX2 cyclooxygenase-2SGLT2i SGLT2 inhibitorSodium-Glucose Transporter 2 InhibitorsGlycated HemoglobinACh acetylcholinebusiness.industryOrganic Chemistrynutritional and metabolic diseasesType 2 Diabetes Mellitusmedicine.diseaseH2K9me2 histone3 lysine9 dimethylationRatsRats ZuckerDHFR dihydrofolate reductaseSGLT2 sodium-glucose co-transporter-2Oxidative StresssGC soluable guanylyl cyclaseGlucose030104 developmental biologyEndocrinologylcsh:Biology (General)ALDH-2 mitochondrial aldehyde dehydrogenaseEndothelium VascularAGE/RAGE signalingHG hyperglycemiabusinessOxidative stressRedox Biology
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The upgrade of the ALICE TPC with GEMs and continuous readout

2020

Journal of Instrumentation 16(03), P03022 (2021). doi:10.1088/1748-0221/16/03/P03022

Physics - Instrumentation and DetectorsComputer sciencePhysics::Instrumentation and DetectorsFOS: Physical sciences61001 natural sciences114 Physical sciences030218 nuclear medicine & medical imaging03 medical and health sciences0302 clinical medicine0103 physical sciencesMicropattern gaseous detectors (MSGC GEM THGEM RETHGEM MHSP MICROPIC MICROMEGAS InGrid etc)Electronicsddc:610Detectors and Experimental TechniquesInstrumentationphysics.ins-detMathematical PhysicsCMOS readout of gaseous detectorsLarge Hadron Collider010308 nuclear & particles physicsbusiness.industryDetectorTime projection Chambers (TPC)Readout electronicsInstrumentation and Detectors (physics.ins-det)ChipUpgradeGaseous imaging and tracking detectorsGas electron multiplierALICE (propellant)businessComputer hardware
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I funghi nella Strategia Globale per la Conservazione delle Piante

2009

I funghi, nonostante siano inseriti in un Regno a parte, sono stati riconosciuti come organismi utili per la definizione di alcune azioni nell’ambito della GSPC (Global Strategy for Plant Conservation). Con l’inserimento del termine generico di “lower plants groups” si è lasciata libera scelta ai Paesi che hanno aderito alla GSPC di valutare l’opportunità di estendere alle crittogame le azioni già in atto per le piante vascolari. Come evidenziato nel recente rapporto sullo “Stato della Biodiversità in Italia” (1) la diversità dei funghi è quantificabile in 4.296 basidiomiceti, tra cui 56 taxa con possibili caratteristiche di endemicità, 12 taxa esotici e 87 rari, minacciati e/o a rischio di…

Settore BIO/02 - Botanica SistematicaSettore BIO/03 - Botanica Ambientale E ApplicataFunghi SGCP Italia
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