Search results for "saRNA"
showing 4 items of 4 documents
A parasitoloxia e a doutrina do contáxio animado: a helmintiase e a sarna na España do século XIX
1990
Les explicacions parasitològiques del contagi eren tant teòriques com observacionals. La triquinosi, la sarna i la helmintiasi van ser exemples primerencs que van demostrar un contagi viu. A principis del segle XIX, en la medicina espanyola, igual que en la medicina europea, es rebutjava el contagi animat excepte en el cas d'alguns paràsits animals com la sarna. En uns altres, com en la helmintiasi intestinal, s'acceptava el seu origen viu, però no la seua contagiositat, i es defensava la seua generació espontània fins a ben entrat el segle XIX. En el “Diccionari de Ciències Mèdiques”, l'estudi dels cucs és quasi exclusivament morfològic i es defensa com a causa de la seua presència en l'ho…
Improvement of In Vivo Expression of Genes Delivered by Self-Amplifying RNA Using Vaccinia Virus Immune Evasion Proteins.
2017
Among nucleic acid–based delivery platforms, self-amplifying RNA (saRNA) vectors are of increasing interest for applications such as transient expression of recombinant proteins and vaccination. saRNA is safe and, due to its capability to amplify intracellularly, high protein levels can be produced from even minute amounts of transfected templates. However, it is an obstacle to full exploitation of this platform that saRNA induces a strong innate host immune response. In transfected cells, pattern recognition receptors sense double-stranded RNA intermediates and via activation of protein kinase R (PKR) and interferon signaling initiate host defense measures including a translational shutdow…
Localized crusted scabies in the acquired immunodeficiency syndrome
1992
Summary Crusted scabies (CrS) is an uncommon occurrence among patients with AIDS. Indeed to date only five cases have been described, all with widespread lesions. A case of localized CrS appearing as a yellowish and crusted plaque on the second right toe is reported in a woman with AIDS. Scraping off the verrucous surface, as well as punch-biopsy revealed many mites within the horny layer. The infestation is related to the cutaneous immune response and thus CrS should be considered an opportunistic infestation in AIDS. The importance of the early diagnosis of CrS in order to prevent disseminated lesions and involvement of other health-care workers is underlined.