Search results for "sairaus"
showing 10 items of 56 documents
Exercise and Metformin Intervention Prevents Lipotoxicity-Induced Hepatocyte Apoptosis by Alleviating Oxidative and ER Stress and Activating the AMPK…
2022
Objective. Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2DM) commonly coexist and act synergistically to drive adverse clinical outcomes. This study is aimed at investigating the effects of exercise intervention and oral hypoglycaemic drug of metformin (MET) alone or combined on hepatic lipid accumulation. To investigate if oxidative stress and endoplasmic reticulum stress (ERS) are involved in lipotoxicity-induced hepatocyte apoptosis in diabetic mice and whether exercise and/or MET alleviated oxidative stress or ERS-apoptosis by AMPK-Nrf2-HO-1 signaling pathway. Methods. Forty db/db mice with diabetes ( random blood glucose ≥ 250 mg / dL ) were randomly allocated i…
Presenteeism in Economic Research
2018
Change is a constant ingredient of modern work life. Thus, job demands and the complexity of job tasks that workers are required to accomplish and perform in everyday work are increasing in organizations and firms. Increasing job demands and incessant changes may be stressful, at least for certain employees, and cause significant and long-lasting health effects as well. Most individuals spend a substantial portion of their total time at work. Thus, work-related behaviours have significant spillover effects on other aspects of life. For these reasons, work-related sickness is also a particularly important aspect of employee well-being from the broader economic perspective. peerReviewed
A kink that makes you sick : The effect of sick pay on absence
2018
We exploit a regression kink design to estimate the elasticity of the duration of sickness absence with respect to replacement rate. Elasticity is a central parameter in defining the optimal social insurance scheme compensating for lost earnings due to sickness. We use comprehensive administrative data and a kink in the policy rule near the median earnings. We find a statistically significant estimate of the elasticity of the order of one. peerReviewed
Work incapacity among family caregivers : a record linkage study
2022
BackgroundFamily caregiving-related physical and mental health problems may lead to work incapacity in employed caregivers. The aim of this study was to quantify sickness absences and disability pensions (SADP) among high-intensity family caregivers available to the labour market compared with a control population.MethodsThe study sample included all individuals in Finland, who had received caregiver’s allowance and were available to the labour market in 2012 (n=16 982) and their controls (n=35 371). Information on the number of sickness absence (spells >10 days) and disability pension (SADP) days and related diagnoses according to ICD-10 were obtained from national registers for the yea…
Kotona asuvan muistisairaan henkilön ja hänen läheistensä teknologiaan liittyvät tarpeet ja toiveet
2018
Tutkimuksessa selvitettiin millaisia tarpeita ja toiveita kotona asuvilla muistisairailla ja heidän läheisillään on kotona asumista tukevaan teknologiaan liittyen. Tutkimukseen osallistui 25 kotona asuvaa muistisairasta henkilöä ja 25 heidän läheistään. Metodina käytettiin etnografista tutkimusotetta. Aineistonkeruumenetelminäolivat avoin haastattelua ja havainnointi. Analyysimenetelmänä käytettiin sisällön analyysiä. Tarpeet ja toiveet voitiin luokitella kolmeen pääluokkaan, jotka olivat itsemääräämisoikeuden säilyminen, sosiaalisten suhteiden säilyminen ja liikkumisen oikeus ja turvallisuus. Haasteita olivat yksinäisyyden kokemus, muistin ja toimintakyvyn heikkenemiseen liittyvät ongelmat…
Xylo-Oligosaccharides in Prevention of Hepatic Steatosis and Adipose Tissue Inflammation: Associating Taxonomic and Metabolomic Patterns in Fecal Mic…
2021
We have shown that prebiotic xylo-oligosaccharides (XOS) increased beneficial gut microbiota (GM) and prevented high fat diet-induced hepatic steatosis, but the mechanisms associated with these effects are not clear. We studied whether XOS affects adipose tissue inflammation and insulin signaling, and whether the GM and fecal metabolome explain associated patterns. XOS was supplemented or not with high (HFD) or low (LFD) fat diet for 12 weeks in male Wistar rats (n = 10/group). Previously analyzed GM and fecal metabolites were biclustered to reduce data dimensionality and identify interpretable groups of co-occurring genera and metabolites. Based on our findings, biclustering provides a use…
Effects of medication, treatment, and behavioral beliefs on intentions to take medication in patients with familial hypercholesterolemia
2018
Although familial hypercholesterolemia (FH) can be effectively managed using cholesterol-lowering medication, patients often fall short of complete treatment adherence. Identifying the psychological factors associated with self-regulation of FH medication is important to inform interventions to maximize adherence. The aim of the present study was to test an integrated psychological model in predicting FH patients' intentions to take medication.FH patients attending clinics in seven countries were invited to participate in a cross-sectional survey study. Consenting patients (N = 551) completed self-report measures of generalized beliefs about medication overuse and harms, beliefs in treatmen…
A randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease
2021
AbstractExercise and diet are treatments for nonalcoholic fatty liver disease (NAFLD) and prediabetes, however, how exercise and diet interventions impact gut microbiota in patients is incompletely understood. We previously reported a 8.6-month, four-arm (Aerobic exercise, n = 29; Diet, n = 28; Aerobic exercise + Diet, n = 29; No intervention, n = 29) randomized, singe blinded (for researchers), and controlled intervention in patients with NAFLD and prediabetes to assess the effect of interventions on the primary outcomes of liver fat content and glucose metabolism. Here we report the third primary outcome of the trial—gut microbiota composition—in participants who completed the trial (22 i…
The effects of using participatory working time scheduling software on sickness absence: A difference-in-differences study.
2020
Abstract Background Participatory working time scheduling is a collaborative approach to scheduling shift work. As a potential way of improving work time control, it may provide a means to reducing sickness absence in shift work. So far, experimental and quasi-experimental studies on the effects of increased work time control on sickness absence are lacking. Objective To investigate the effects of using digital participatory working time scheduling software on ward-level sickness absence among Finnish hospital employees. Participants and methods This quasi-experimental study compared the amount of sickness absence in hospital wards using a participatory working time scheduling software (n=1…
Sickness Absence at Work and Supporting Being Present At Work, Among Employees Working Different Shifts in the Forest Industry
2015
Objective: Shift work has negative effects on employee overall health, including sleep disorder, depressive symptoms, and cardiovascular and metabolic diseases. The association between shift work and the prevalence of sickness absence has been less studied. This study investigated sickness absence among employees working different work shift schedules in the forest industry. Method: This descriptive cross-sectional study used employee (N=636) data from forest industry sick-leave registers. The study population (n=280; women n=90 and men=189) worked five different shifts. Each of the five shifts was analyzed separately for sickness absence rate and the results were compared using independent…