Search results for "salsolinol"

showing 3 items of 3 documents

Mystic Acetaldehyde: The Never-Ending Story on Alcoholism

2017

After decades of uncertainties and drawbacks, the study on the role and significance of acetaldehyde in the effects of ethanol seemed to have found its main paths. Accordingly, the effects of acetaldehyde, after its systemic or central administration and as obtained following ethanol metabolism, looked as they were extensively characterized. However, almost 5 years after this research appeared at its highest momentum, the investigations on this topic have been revitalized on at least three main directions: (1) the role and the behavioral significance of acetaldehyde in different phases of ethanol self-administration and in voluntary ethanol consumption; (2) the distinction, in the central e…

0301 basic medicineCognitive Neuroscienceethanol acetaldehyde salsolinol ethanol metabolism epigenetics neuroinflammation mesolimbic system dopamineReviewPharmacologyConsumption (sociology)neuroinflammationlcsh:RC321-571Developmental psychologyethanol metabolism03 medical and health sciencesBehavioral Neurosciencechemistry.chemical_compound0302 clinical medicineEthanol metabolismsalsolinollcsh:Neurosciences. Biological psychiatry. NeuropsychiatryepigeneticsAcetaldehyde030104 developmental biologyNeuropsychology and Physiological Psychologymesolimbic systemchemistryethanoldopaminePsychology030217 neurology & neurosurgeryNeuroscienceacetaldehydeFrontiers in Behavioral Neuroscience
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Salsolinol and ethanol-derived excitation of dopamine mesolimbic neurons: new insights

2013

Evidence supporting the essential role of brain-derived ethanol metabolites in the excitation of dopamine (DA) midbrain neurons has multiplied in the last 10–15 years. The pioneer and influential behavioral studies by CM Aragon and colleagues (see Correa et al., 2012 for a complete review) and more recent data (Sanchez-Catalan et al., 2009; Marti-Prats et al., 2010, 2013) have repeatedly demonstrated the crucial role displayed by acetaldehyde (ACD) in the locomotor and other behavioral responses elicited by ethanol. Although these experiments mainly used an indirect measure (exploratory locomotion) as an index of the excitation of DA neurons in the ventral tegmental area (VTA), results stro…

Cognitive NeuroscienceAcetaldehydeStriatumInhibitory postsynaptic potentiallcsh:RC321-571Behavioral NeuroscienceGlutamatergicDopaminemedicinePremovement neuronal activitylcsh:Neurosciences. Biological psychiatry. NeuropsychiatryGeneral Commentary ArticleSalsolinolElectrophysiologyVentral tegmental areaµ-Opioid ReceptorsElectrophysiologyNeuropsychology and Physiological Psychologymedicine.anatomical_structurenervous systemHypothalamusDopamine Midbrain NeuronsPsychologyNeuroscienceNeurosciencemedicine.drugFrontiers in Behavioral Neuroscience
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Acetaldehyde and salsolinol in ethanol’s two-step mechanism of action: An overview

2018

In the last years, numerous studies have supported the idea that, at least in part, motivational and neuropharmacological effects of ethanol are mediated by its first brain-derived metabolite, acetaldehyde, and its bioderivate salsolinol. This review aims at gathering and shaping as a whole the evidence on their role in the mechanism of action of ethanol. Acetaldehyde and salsolinol interact with the reward brain system and are involved as primum movens of motivational and addictive behaviour that can be especially relevant to ethanol use disorders. Understanding the neurobiology of acetaldehyde and salsolinol holds promising potential for the development of novel pharmacological approaches…

EthanolEthanolBiochemistry (medical)Two stepAcetaldehydeAcetaldehydePlant ScienceCombinatorial chemistryGeneral Biochemistry Genetics and Molecular BiologySalsolinolchemistry.chemical_compoundethanol acetaldehyde salsolinol rewardRewardchemistryMechanism of actionlcsh:Biology (General)medicinemedicine.symptomlcsh:QH301-705.5Journal of Biological Research
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