Search results for "satellite"
showing 10 items of 1031 documents
Expression of a mutant HSP110 sensitizes colorectal cancer cells to chemotherapy and improves disease prognosis
2011
Heat shock proteins (HSPs) are necessary for cancer cell survival. We identified a mutant of HSP110 (HSP110ΔE9) in colorectal cancer showing microsatellite instability (MSI CRC), generated from an aberrantly spliced mRNA and lacking the HSP110 substrate-binding domain. This mutant was expressed at variable levels in almost all MSI CRC cell lines and primary tumors tested. HSP110ΔE9 impaired both the normal cellular localization of HSP110 and its interaction with other HSPs, thus abrogating the chaperone activity and antiapoptotic function of HSP110 in a dominant-negative manner. HSP110ΔE9 overexpression caused the sensitization of cells to anticancer agents such as oxaliplatin and 5-fluorou…
Measurements of total ozone amount over Badajoz (Southwestern Spain) by means of a GUV multiband radiometer
2012
This paper presents the first measurements of total ozone amount performed at the radiometric station of Badajoz (Spain) by means of a multichannel radiometer GUV-2511. The retrieval of total ozone amount from GUV measurements of solar ultraviolet irradiance is performed with the support of look-up tables calculated using the SBDART radiation transfer code. This methodology is based on the different absorption by ozone suffered by the radiation at two certain near wavelengths. In this case the pair 305, 340 nm was chosen because of its better performance than the pair 305, 320 nm. The look-up table contains the ratio between irradiances at the mentioned wavelengths calculated under differen…
Fragmentation-related patterns of genetic differentiation in pedunculate oak (Quercus robur) at two hierarchical scales
2016
Populations at species' range margins are expected to show lower genetic diversity than populations at the core of the range. Yet, long-lived, widespread tree species are expected to be resistant to genetic impoverishment, thus showing comparatively high genetic diversity within populations and low differentiation among populations. Here, we study the distribution of genetic variation in the pedunculate oak (Quercus robur L.) at its range margin in Finland at two hierarchical scales using 15 microsatellite loci. At a regional scale, we compared variation within versus among three oak populations. At a landscape scale, we examined genetic structuring within one of these populations, growing …
NRTK, PPP or Static, That Is the Question. Testing Different Positioning Solutions for GNSS Survey
2021
Worldwide, the determination of the coordinates from a Global Navigation Satellite System (GNSS) survey (in Network Real Time Kinematic, Precise Point Positioning, or static mode) has been analysed in several scientific and technical applications. Many of those have been carried out to compare Precise Point Positioning (PPP), Network Real Time Kinematic (NRTK), and static modes’ solutions, usually, using the latter as the true or the most plausible solution. This approach is not always possible as the static mode solution depends on several parameters (baseline length, acquisition time, ionospheric, and tropospheric models, etc.) that must be considered to evaluate the accuracy of the metho…
STR genotyping and mtDNA sequencing of latent fingerprint on paper
2003
A systematic study was conducted to investigate whether DNA can be successfully extracted from latent fingerprints deposited on ordinary paper and analysed using short tandem repeat profiling and mitochondrial DNA sequencing. In order to evaluate the performance of latent fingerprint analysis in a criminal case, experiments with varying conditions were carried out to improve our understanding of low copy number (LCN) DNA typing. After optimising the extraction methods to achieve increased sensitivity, the examination of touched paper can routinely yield the STR profile of the individual who has touched it. A fingerprint can therefore be considered as a potential source of DNA for genetic id…
Population differentiation in the marginal populations of the great tit (Paridae: Parus major)
2007
The major subspecies group of the great tit, Parus major, has experienced demographic and spatial expansions during the last century in several sites at the edges of its distribution range. These expansions, although temporarily very even, have resulted in dissimilar patterns of molecular diversity. Populations locating at regions of contact to other subspecies groups (in Amur, Kirghizia–Kazakhstan, and Iran) show divergence from central population by nuclear and mitochondrial markers. In Amur, gene flow from minor group could be detected based on the existence of private minor alleles in the major population. In Kirghizia and Kazakhstan, the bokharensis and major groups share almost all th…
Global vegetation monitoring through multitemporal analysis of pathfinder AVHRR land database
2005
We have applied a Land Surface Temperature algorithm to the whole Pathfinder AVHRR Land (PAL) database, aiming at studying the evolution of the vegetation at a global scale. The Land Surface Temperature parameter, along with NDVI, will allow retrieving vegetation changes between July 1981 and September 2001. We have also built a classification which takes into account both vegetation variations and thermal patterns, from NDVI and Air Temperature at 2 meters height data. This classification allows differentiating areas which present close vegetation changes throughout the year, but totally different climates, as for example in mountainous and semiarid regions. The main quality of this classi…
Microsatellite Instability in Colorectal Cancer: Time to Stop Hiding!
2011
Colorectal cancer (CRC) is the second cause of cancer-related death worldwide. Surgery constitutes the primary therapy for these tumors, together with chemotherapy that is usually recommended in patients with metastatic primary CRC. Although molecularly distinct entities arising from different physiopathogenic mechanisms - microsatellite (MSI) and chromosomal instability (also called microsatellite stable, MSS) - have been characterized in CRC, there is still no specific therapeutic approach that takes into account disease’s molecular heterogeneity [1]. MSI is observed in 1015% of sporadic CRCs. MSI CRCs displayed particular morphologic features, with greater predilection for the right colo…
SAPERE ECONOMICO E METODO SCIENTIFICO NELL’ILLUMINISMO LOMBARDO: NOTE DA “IL CAFFÈ”
2011
Economic knowledge and scientific method in the lombard enlightenment. Notes from «Il caffè». The connections, emerging between the 16th and the 18th century, between the evolution of economic knowledge and the rise of the scientific method, are important research topics for historians of economic ideas. However, further research on the application of the scientific method is still needed, especially when we come to the analysis of how economic principles took shape in Lombardy during the Enlightenment. The same need for further research concerns the debates on economic policy during the Age of Reforms in the latter half of the eighteenth century. This is even more necessary for Milanese En…
The DArk Matter Particle Explorer mission
2017
The DArk Matter Particle Explorer (DAMPE), one of the four scientific space science missions within the framework of the Strategic Pioneer Program on Space Science of the Chinese Academy of Sciences, is a general purpose high energy cosmic-ray and gamma-ray observatory, which was successfully launched on December 17th, 2015 from the Jiuquan Satellite Launch Center. The DAMPE scientific objectives include the study of galactic cosmic rays up to $\sim 10$ TeV and hundreds of TeV for electrons/gammas and nuclei respectively, and the search for dark matter signatures in their spectra. In this paper we illustrate the layout of the DAMPE instrument, and discuss the results of beam tests and calib…