Search results for "sato"

showing 10 items of 116 documents

Computational analysis of lung deformation after murine pneumonectomy. [corrected].

2012

In many mammalian species, the removal of one lung (pneumonectomy) is associated with the compensatory growth of the remaining lung. To investigate the hypothesis that parenchymal deformation may trigger lung regeneration, we used microCT scanning to create 3-dimensional finite element geometric models of the murine lung pre- and post-pneumonectomy (24 hours). The structural correspondence between models was established using anatomic landmarks and an iterative computational algorithm. When compared with the pre-pneumonectomy lung, the post-pneumonectomy models demonstrated significant translation and rotation of the cardiac lobe into the post-pneumonectomy pleural space. 2-dimensional maps…

Models AnatomicPathologymedicine.medical_specialtyX-ray microtomographymedicine.medical_treatmentFinite Element AnalysisBiomedical EngineeringCompensatory growth (organ)BioengineeringBiologyDeformation (meteorology)ArticlePneumonectomyMiceParenchymamedicineAnimalsRegenerationComputational analysisPneumonectomyLungLungGeneral MedicineAnatomyX-Ray Microtomographyrespiratory systemLoberespiratory tract diseasesComputer Science ApplicationsHuman-Computer InteractionMice Inbred C57BLmedicine.anatomical_structureComputer methods in biomechanics and biomedical engineering
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Redox signaling in acute pancreatitis

2015

Acute pancreatitis is an inflammatory process of the pancreatic gland that eventually may lead to a severe systemic inflammatory response. A key event in pancreatic damage is the intracellular activation of NF-κB and zymogens, involving also calcium, cathepsins, pH disorders, autophagy, and cell death, particularly necrosis. This review focuses on the new role of redox signaling in acute pancreatitis. Oxidative stress and redox status are involved in the onset of acute pancreatitis and also in the development of the systemic inflammatory response, being glutathione depletion, xanthine oxidase activation, and thiol oxidation in proteins critical features of the disease in the pancreas. On th…

NecrosisGSH reduced glutathioneSTAT3 signal transducer and activator of transcription 3ERK extracellular signal-regulated kinasesClinical BiochemistryCCK cholecystokininTRAFs TNF receptor associated factorsReview ArticleIκB kinasePharmacologymedicine.disease_causeBiochemistrySHP small heterodimer partnerSTIM1 stromal interaction molecule 1chemistry.chemical_compoundHATs histone acetyltransferasesMedicineASK1GCL glutamate cysteine ligaseTNF-α tumor necrosis factor alphaIKK IκB kinaseNOS nitric oxide synthaseAcute inflammationHIF hypoxia inducible factorlcsh:QH301-705.5NF-κB nuclear factor kappa BDAMPs damage-associated molecular pattern moleculeslcsh:R5-920biologyGSSG oxidized glutathioneNF-kappa BNLRs nucleotide-binding oligomerization domain (NOD) like receptorsTRADD tumor necrosis factor receptor type 1-associated DEATH domain proteinTRPC3 transient receptor potential channel 3VEGF vascular endothelial growth factorGlutathioneTNFR tumor necrosis factor receptorHMGB1 high-mobility group Box 1 proteinIP3R inositol 145-trisphosphate receptor type 3VCAM-1 Vascular Cell adhesion protein 1Acute DiseaseJNK c-Jun N-terminal kinaseAcute pancreatitisTLRs toll-like receptorsmedicine.symptomlcsh:Medicine (General)Oxidation-ReductionAP-1 activator protein-1Signal TransductionmRNA messenger ribonucleic acidHMGB1ASC apoptosis-associated speck-like protein containing a carboxy-terminal CARDRNS reactive nitrogen speciesPTPs protein tyrosine phosphatasesROS reactive oxygen speciesNADH nicotinamide adenine dinucleotidepHe extracellular pHFAEE fatty acid ethyl estersAP acute pancreatitisHumansXanthine oxidaseCBP CREB-binding proteinRyR endoplasmic reticulum membrane ryanodine receptorsMDA malondialdehydeNO nitric oxideXO xanthine oxidaseASK1 apoptosis signal-regulating kinase-1business.industryOrganic ChemistryAutophagyNADPH nicotinamide adenine dinucleotide phosphateHDACs histone deacetylasesmedicine.diseaseCARS compensatory anti-inflammatory response syndromeXDH xanthine dehydrogenaseIL interleukinIκB inhibitor of kappa BAcute pancreatitisETC Electron transport chainPancreatitisMKPs MAPK phosphatasesSAP severe acute pancreatitischemistrylcsh:Biology (General)DTT dithiothreitolOxidative stressNAC N-acetyl cysteineImmunologybiology.proteinCalciumLysosomesReactive Oxygen SpeciesbusinessMAPK mitogen-activated protein kinaseOxidative stressERCP endoscopic retrograde cholangiopancreatographyRedox Biology
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Sprouting and intussusceptive angiogenesis in postpneumonectomy lung growth: mechanisms of alveolar neovascularization

2013

In most rodents and some other mammals, the removal of one lung results in compensatory growth associated with dramatic angiogenesis and complete restoration of lung capacity. One pivotal mechanism in neoalveolarization is neovascularization, because without angiogenesis new alveoli can not be formed. The aim of this study is to image and analyze three-dimensionally the different patterns of neovascularization seen following pneumonectomy in mice on a sub-micron-scale. C57/BL6 mice underwent a left-sided pneumonectomy. Lungs were harvested at various timepoints after pneumonectomy. Volume analysis by microCT revealed a striking increase of 143 percent in the cardiac lobe 14 days after pneum…

Pathologymedicine.medical_specialtyCancer ResearchAngiogenesisPhysiologymedicine.medical_treatmentClinical BiochemistryCompensatory growth (organ)Neovascularization Physiologic610 Medicine & healthVascular RemodelingBiologyCorrosion CastingNeovascularizationPneumonectomymedicineAnimalsIntussusceptive angiogenesisLung volumesIntussusceptive angiogenesisPneumonectomyCorrosion castLung surgeryTomographySprouting angiogenesisOriginal PaperMicroscopyLungfungiSynchrotron radiation tomographic microscopyAnatomySynchrotron radiation tomographicrespiratory systemIntussusceptive angiogenesis; Pneumonectomy; Septal alveolarization; Corrosion cast; Synchrotron radiation tomographic; Microscopy; Lung surgerySeptal alveolarizationMice Inbred C57BLPulmonary Alveolimedicine.anatomical_structure570 Life sciences; biologysense organsmedicine.symptomSynchrotrons
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Mapping cyclic stretch in the postpneumonectomy murine lung

2013

In many mammalian species, the removal of one lung [pneumonectomy (PNX)] is associated with the compensatory growth of the remaining lung. To investigate the hypothesis that parenchymal deformation may trigger lung regeneration, we used respiratory-gated micro-computed tomography scanning to create three-dimensional finite-element geometric models of the murine cardiac lobe with cyclic breathing. Models were constructed of respiratory-gated micro-computed tomography scans pre-PNX and 24 h post-PNX. The computational models demonstrated that the maximum stretch ratio map was patchy and heterogeneous, particularly in subpleural, juxta-diaphragmatic, and cephalad regions of the lobe. In these…

Pathologymedicine.medical_specialtyPhysiologymedicine.medical_treatmentCompensatory growth (organ)PneumonectomyMicePhysiology (medical)ParenchymamedicineShear stressAnimalsRegenerationPneumonectomyLungLungChemistryRespirationAnatomyArticlesLobeMice Inbred C57BLmedicine.anatomical_structureBreathingTomographyStress MechanicalLung Volume MeasurementsTomography X-Ray Computed
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Regulatory Network Of Angiogenesis Gene Expression During Post-Pneumonectomy Compensatory Growth

2011

PneumonectomyAngiogenesismedicine.medical_treatmentGene expressionCompensatory growth (organ)medicineCancer researchBiologyA61. LUNG ENDOTHELIUM FUNCTIONS: THE BARRIER AND BEYOND
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Invasive and native populations of common ragweed exhibit strong tolerance to foliar damage.

2013

8 pages; International audience; Tolerance and resistance are defence strategies evolved by plants to cope with damage due to herbivores. The introduction of exotic species to a new biogeographical range may alter the plant herbivore interactions and induce selection pressures for new plant defence strategies with a modified resource allocation. To detect evolution in tolerance to herbivory in common ragweed, we compared 3 native (North America) and 3 introduced (France) populations, grown in a common garden environment. We explored the effect of leaf herbivory on plant vegetative and reproductive traits. Plants were defoliated by hand, simulating different degrees of insect grazing by remo…

RagweedHerbivore[ SDE.BE ] Environmental Sciences/Biodiversity and EcologybiologyResistance (ecology)fungiBiological pest controlfood and beveragesIntroduced speciesbiology.organism_classificationInvasive speciesAgronomyDefoliationShootFitness[ SDV.EE.IEO ] Life Sciences [q-bio]/Ecology environment/SymbiosisCompensatory growth[SDE.BE]Environmental Sciences/Biodiversity and EcologySimulated herbivoryEcology Evolution Behavior and SystematicsAmbrosia artemisiifoliaFunctional traits[SDV.EE.IEO]Life Sciences [q-bio]/Ecology environment/SymbiosisAmbrosia artemisiifolia
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”Ja Rosatom on varmasti erittäin hyvä toimija myös Fennovoimalle” : kuinka kansanedustajat perustelivat venäläistä ydinvoimakytköstä

2022

Venäjä miehitti Krimin niemimaan keväällä 2014. Kärjistyneestä geopoliittisesta tilanteesta huolimatta eduskunta hyväksyi samana vuonna Fennovoiman ydinvoimalahankkeen, jossa keskeisessä roolissa oli venäläinen valtionyhtiö Rosatom. nonPeerReviewed

Rosatompoliittinen päätöksentekopakotteetFennovoimaulkopolitiikkakansainväliset suhteetgeopolitiikkaydinvoimalatenergiapolitiikkaVenäjäSuomiUkrainan kriisi 2014-energiantuotantoturvallisuuspolitiikka
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Compensatory Policies in Europe. Some lessons for Mexico ?

2019

International audience

Réduction des inégalités[SHS.EDU]Humanities and Social Sciences/EducationRéseau d'éducation prioritaire[SHS.EDU] Humanities and Social Sciences/EducationPolitique éducativeJustice socialeEducation compensatoireEquityEducation comparéeZone d'éducation prioritaireEducation PolicyEducationEuropeSocial JusticeComparative EducationMexiqueEquitéReducing Social InequalitiesMexicoComputingMilieux_MISCELLANEOUS
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Pour une régulation des politiques compensatoires : quels éléments prendre en considération pour mettre en place une politique d'éducation prioritair…

2001

Actes des journées internationales de réflexion et d'échanges - Hammamet (Tunisie) du 22 au 24 mars 2001; International audience

Régulation[SHS.EDU]Humanities and Social Sciences/Education[SHS.EDU] Humanities and Social Sciences/EducationPolitique éducativeÉducation compensatoireZone d'éducation prioritaire
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Riconciliare il passato. Selinunte: una frontiera al centro del Mediterraneo tra storia identià e ritorno

2011

Turismo antico e moderno: Selinunte crocevia critico per una rilelaborazione del turismo culturale e la salvaguardia del patrimonio archeologico

Selinunte turismo culturale passato tradizione presenteSettore L-ANT/02 - Storia Greca
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