Search results for "screening"
showing 10 items of 1150 documents
Intron variants of the p53 gene are associated with increased risk for ovarian cancer but not in carriers of BRCA1 or BRCA2 germline mutations
1999
Two biallelic polymorphisms in introns 3 and 6 of the p53 gene were analysed for a possible risk-modifying effect for ovarian cancer. Germline DNA was genotyped from 310 German Caucasian ovarian cancer patients and 364 healthy controls. We also typed 124 affected and 276 unaffected female carriers with known deleterious BRCA1 or BRCA2 germline mutation from high-risk breast-ovarian cancer families. Genotyping was based on PCR and high-resolution gel electrophoresis. German ovarian cancer patients who carried the rare allele of the MspI restriction fragment length polymorphism (RELP) in intron 6 were found to have an overall 1.93-fold increased risk (95% confidence internal (CI) 1.27–2.91) w…
Testing for Lynch Syndrome in Endometrial Carcinoma: From Universal to Age-Selective MLH1 Methylation Analysis
2022
Simple Summary International guidelines recommend universal screening of endometrial carcinoma patients for Lynch syndrome, a hereditary cancer predisposition syndrome. Screening is based on mismatch repair protein immunohistochemistry and reflex MLH1 methylation analysis to exclude the likely sporadic cases of MMR deficiency. As sporadic MLH1 protein loss is common in endometrial carcinoma, the ability to target methylation testing would save efforts and costs. We discovered that limiting methylation testing to patients under 65 years would have significantly reduced the testing effort while maintaining a low false negative rate for MLH1-LS detection (0% and 3% in our clinic and registry-b…
A dynamic-common pharmacophore approach to improve virtual screening. A case study on PPAR-alpha
2016
Motorisen oppimisen vaikeuden tunnistaminen ja tukeminen kouluympäristössä
2018
Motorisen oppimisen vaikeudella, kuten kehityksellisellä koordinaatiohäiriöllä (DCD), tarkoitetaan huomattavaa vaikeutta oppia uusia motorisia taitoja ja soveltaa jo opittuja taitoja uusiin tilanteisiin. Tämän tutkimuksen tarkoituksena oli kehittää opettajien käyttöön havainnointityökalu, joka auttaa tunnistamaan motorisen oppimisen vaikeuden esi- ja alkuopetusikäisillä lapsilla. Lisäksi tutkimus selvitti, miten opettajat voivat kouluympäristössä tukea lapsia, joilla on haasteita motorisessa oppimisessa. Tutkimus muodostui neljästä osatutkimuksesta. Ensimmäisessä tutkittiin systemaattisen kirjallisuuskatsauksen avulla maailmalla käytössä olevien havainnointilomakkeiden psykometrisiä ominais…
An Ethical Investments Evaluation for Portfolio Selection
2004
The Socially Responsible Investing (SRI) is an assets allocation, whose aim is to maximize not only the portfolio expected return but the benefits for a consumer who as a whole operates according to the ethical principles. The wealth of a market economy is to cross the different ethical identities of families, of enterprises, of banks, in order to improve the allocation of the resources for a sustainable development. In this paper, we aim at describing the portfolio selection realized on the basis of the ethical principles - positive /negative, inclusionary/exclusionary - of an investor. The first part of this paper describes Socially Responsible Investing (SRI) and ethical funds market in …
Preoperative Anemia and Iron Deficiency Screening, Evaluation and Management: Barrier Identification and Implementation Strategy Mapping
2020
Alana Delaforce,1,2 Jed Duff,1,3 Judy Munday,3,4 Janet Hardy2 1School of Nursing and Midwifery, The University of Newcastle, Callaghan, NSW, Australia; 2Mater Health Services, South Brisbane, QLD 4101, Australia; 3School of Nursing/Centre for Healthcare Transformation, Queensland University of Technology, Kelvin Grove, QLD, Australia; 4School of Nursing, The University of Agder, Kristiansand, NorwayCorrespondence: Alana Delaforce Email alana.delaforce@mater.org.auIntroduction and aims: Patients undergoing major surgery risk significant blood loss and transfusion, which increases substantially if they have pre-existing anemia. Preoperative Anemia and Iron Deficiency Screening, Evaluation and…
Drug Screening by Inkjet Printing Microarrays
2010
Multidimensional instruments with an integral approach to identify frailty in community-dwelling people: protocol for a systematic psychometric review
2019
IntroductionAn increasing number of investigations highlight the complex nature of frailty; therefore, the use of multidimensional assessment instruments could be useful in clinical decision-making. Frail people are found mainly in the community setting which is why this is the ideal environment for early screening and intervention. For this purpose, it is necessary to have valid, time-effective and easy-to-use frailty assessment instruments. The aim of this review is to critically appraise, compare and summarise the quality of the measurement properties of all multidimensional instruments with an integral approach to identify frailty in community-dwelling people.Methods and analysisMedline…
Sosiaalinen media - mahdollisuudet ja haasteet rekrytoinnissa
2018
Sosiaalisen median käyttö lisääntyy jatkuvasti. Myös monet yritykset ovat ottaneet sen käyttöönsä. Tässä tutkielmassa perehdytään sosiaalisen median käyttöön yrityksen rekrytoinnissa. Tutkielman näkökulmana toimii työnantajan näkökulma. Sosiaalisen median käytöllä katsotaan olevan sekä positiivisia, että negatiivisia seurauksia yrityksen rekrytoinnille. Tutkielma on toteutettu kirjallisuuskatsauksena ja siinä tutkitaan sosiaalisen median tuomia hyötyjä ja haittoja yrityksen rekrytointiprosessiin. Tutkimuksen tulosten mukaan sosiaalinen media tuo enemmän positiivisia asioita yrityksen rekrytointiin, kuin negatiivisia. Sosiaalinen media laskee yrityksen rekrytointikuluja merkittävästi ja lyhe…
Colonoscopic screening of first-degree relatives of patients with large adenomas: increased risk of colorectal tumors.
2007
International audience; Background & Aims: The risk of developing colorectal neoplasia is not well established among family members of individuals with large adenomas and screening strategies remain under debate in this population. This study aimed at quantifying the risk of colorectal adenomas and cancers using colonoscopic screening in first-degree relatives of patients with large adenomas. Methods: This case-control study was performed in 18 endoscopic units of French non-University Hospitals. A colonoscopy was offered to first-degree relatives of 306 index cases with adenomas ≥ 10 mm, if they were alive, aged 40-75 and could be contacted by the index case. Among 674 relatives meeting th…