Search results for "script"
showing 10 items of 5143 documents
Session details: Distributed systems: WT - web technologies track
2018
The Web is relentlessly evolving. Once a single interconnection of static, physically distributed content passively accessed by human users through personal computers, during the explosion of Web-based social networks the Web evolved into an environment allowing users worldwide to interact and collaborate to create user-generated content within many virtual communities. In this line, Web 2.0 is the umbrella term used to encompass several developments which followed, namely social networking sites and social media sites (e.g., Facebook), blogs, wikis, folksonomies (e.g. Flickr), video sharing sites (e.g., YouTube), Web applications ("apps"), collaborative platforms, and mashup applications. …
Epigrafía funeraria nazarí: el epitafio de al-Yanaštī (835/1436)
2016
Este artículo analiza la epigrafía funeraria nazarí y establece la estructura de los epitafios andalusíes conservados datables entre los siglos XIII y XV. Se estudia también una pieza arqueológica cuyo exacto origen se desconoce, aunque se puede deducir que apareció en la región de Granada. La piedra se usó en el siglo XV para grabar el epitafio de un hombre musulmán cuyo texto se conserva completo en siete líneas de escritura árabe cursiva en relieve. Formó parte de la colección del Duque de Santa Lucía y hoy integra el lapidario árabe del Museo Arqueológico Nacional (Nº. Inv. 1962/34/15).
Sometimes less is more—the impact of the number of His residues on the stability of Zn(ii)–SmtB and BigR4 α-5 domain complexes
2021
The increasing number of antibiotic-resistant pathogens has become one of the major health problems of modern times, including infections caused by Mycobacterium tuberculosis. One of the possible mammalian immune system responses to mycobacterial infection is the increase of the zinc(II) concentration in phagosomes to a toxic level. The mycobacterial SmtB protein belongs to the family of ArsR/SmtB transcription regulators. In the presence of high concentrations of metals, SmtB dissociates from DNA and activates the expression of metal efflux proteins. In this work, we focus on the α5 zinc(II) binding domains of SmtB/BigR4 proteins (the latter being the SmtB homolog from non-pathogenic M. sm…
FORMAL CONCEPTION OF ROUGH SETS
1996
In the paper we present a formal description of rough sets within the framework of the generalized set theory, which is interpreted in the set approximation theory. The rough sets are interpreted as approximations, which are defined by means of the Pawlak's rough sets.
Formal Description of Rough Sets
1994
In the paper we present a formal description of rough sets within the limits of the generalized set theory, which is interpreted in the approximation of set theory. The rough sets are interpreted as an approximations, which are defined by means of the Pawlak’s rough sets.
Change in expression of MGMT during maturation of human monocytes into dendritic cells.
2005
Dendritic cells (DCs) maturated from monocytes play an important role in the immune system, not only in defense against conventional infections but also in cancer rejection. Because of the central role of DCs in tumor host defense it is highly important that DCs as well as the progenitor cell population are protected during cancer therapy. Since most anticancer drugs target DNA, the DNA repair capacity is most importance for the response of DCs and their precursor cells. Here, we studied the expression of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) in monocytes obtained from peripheral blood of healthy donors and DCs maturated from monocytes (moDCs). We show that MG…
Activation of c-Jun N-terminal kinase 1 by UV irradiation is inhibited by wortmannin without affecting c-iun expression.
1999
Activation of c-Jun N-terminal kinases (JNKs)/stress-activated protein kinases is an early response of cells upon exposure to DNA-damaging agents. JNK-mediated phosphorylation of c-Jun is currently understood to stimulate the transactivating potency of AP-1 (e.g., c-Jun/c-Fos; c-Jun/ATF-2), thereby increasing the expression of AP-1 target genes. Here we show that stimulation of JNK1 activity is not a general early response of cells exposed to genotoxic agents. Treatment of NIH 3T3 cells with UV light (UV-C) as well as with methyl methanesulfonate (MMS) caused activation of JNK1 and an increase in c-Jun protein and AP-1 binding activity, whereas antineoplastic drugs such as mafosfamide, mito…
Mucosal immunoregulation: transcription factors as possible therapeutic targets.
2005
Much progress has been recently made with regard to our understanding of the mucosal immune system in health and disease. In particular, it has been shown that uncontrolled mucosal immune responses driven by lymphocytes or non-lymphoid cells may lead to immunological diseases such as allergy, hypersensitivity and inflammation. Thus, a more detailed understanding of mucosal immune regulation and decision making at mucosal surfaces is essential for a better understanding of mucosal immune responses in health and disease. Antigen presenting cells and T lymphocytes play a key role in controlling mucosal immune responses. To deal with this key task, T helper cells differentiate into functionally…
Effective treatment of allergic airway inflammation with Helicobacter pylori immunomodulators requires BATF3-dependent dendritic cells and IL-10
2014
The prevalence of allergic asthma and other atopic diseases has reached epidemic proportions in large parts of the developed world. The gradual loss of the human indigenous microbiota has been held responsible for this trend. The bacterial pathogen Helicobacter pylori is a constituent of the normal gastric microbiota whose presence has been inversely linked to allergy and asthma in humans and experimental models. Here we show that oral or i.p. tolerization with H. pylori extract prevents the airway hyperresponsiveness, bronchoalveolar eosinophilia, pulmonary inflammation, and Th2 cytokine production that are hallmarks of allergen-induced asthma in mice. Asthma protection is not conferred by…
Stabilization of hsp70 mRNA on prolonged cell exposure to hypertonicity
2002
AbstractProlonged exposure of 3T3 cells to 0.5 osM hypertonic medium induced the accumulation of hsp70 mRNAs. This increase in mRNA levels required active protein synthesis. A weak and transient activation of heat shock factor 1 (HSF1) was noted, but it was temporally uncoupled to the accumulation of the hsp70 mRNAs. Nuclear run-on assay and transfection experiments showed that hsp70 gene transcription was not affected by hypertonicity. ActD chase experiments showed that during hypertonic treatment, degradation of hsp70 mRNAs was markedly reduced. This effect did not appear to be a general phenomenon since the increase in mRNA level of another gene induced by hypertonicity (ATA2 transporter…